56341-31-2

Basic information

• Product Name: 2-BROMO-9H-XANTHEN-9-ONE
• Synonyms: 2-BROMO-9H-XANTHEN-9-ONE;2-BroMoxanthone;2-bromo-9-xanthenone;2-bromoxanthen-9-one;SBB010036
• CAS NO: 56341-31-2
• Molecular Formula: C₁₃H₇BrO₂
• Molecular Weight: 275.1
• Mol File: 56341-31-2.mol
• Article Data: 26

Chemical Properties

• Melting Point: 150 °C(Solv: ethanol (64-17-5); water (7732-18-5))
• Boiling Point: 403.2°C at 760 mmHg
• Flash Point: 197.7°C
• Appearance: /
• Density: 1.62g/cm³
• Vapor Pressure: 1.03E-06mmHg at 25°C
• Refractive Index: 1.667
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-BROMO-9H-XANTHEN-9-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-9H-XANTHEN-9-ONE(56341-31-2)
• EPA Substance Registry System: 2-BROMO-9H-XANTHEN-9-ONE(56341-31-2)

Safety Data

• Hazardous Substances Data: 56341-31-2(Hazardous Substances Data)

Usage

Description

2-BROMO-9H-XANTHEN-9-ONE, also known as 2-Bromoxanthone, is a derivative of Xanthone (X500100) and belongs to an important class of oxygenated heterocycles. It is characterized by the presence of a bromine atom at the 2nd position of the xanthone structure, which contributes to its unique properties and potential applications.

Uses

Used in Pharmaceutical Industry:
2-BROMO-9H-XANTHEN-9-ONE is used as a pharmaceutical compound for its potential antitumor, antidiabetic, and antihypertensive activity. Its chemical structure allows it to interact with various biological targets, making it a promising candidate for the development of new drugs to treat cancer, diabetes, and hypertension.
Used in Anticancer Applications:
In the field of oncology, 2-BROMO-9H-XANTHEN-9-ONE is used as an anticancer agent due to its potential to target and inhibit tumor growth. Its oxygenated heterocycle structure enables it to modulate various oncological signaling pathways, which can lead to the inhibition of tumor progression and the enhancement of the effectiveness of conventional chemotherapeutic drugs.
Used in Antidiabetic Applications:
2-BROMO-9H-XANTHEN-9-ONE is used as an antidiabetic agent, where it may help in the regulation of blood sugar levels and improve insulin sensitivity. Its potential to target specific metabolic pathways involved in diabetes makes it a valuable compound for the development of new treatments for diabetes.
Used in Antihypertensive Applications:
In the context of cardiovascular health, 2-BROMO-9H-XANTHEN-9-ONE is used as an antihypertensive agent. Its ability to modulate blood pressure regulation mechanisms can contribute to the development of new therapies for the treatment of hypertension and related cardiovascular diseases.
Overall, 2-BROMO-9H-XANTHEN-9-ONE is a versatile compound with potential applications in various industries, particularly in the pharmaceutical sector, where its unique properties make it a promising candidate for the development of new drugs to address a range of health conditions.

InChI:InChI=1/C13H7BrO2/c14-8-5-6-12-10(7-8)13(15)9-3-1-2-4-11(9)16-12/h1-7H

Upstream product

• 90-47-1 xanth-9-one 
• 106-41-2 4-bromo-phenol 
• 118-91-2 ortho-chlorobenzoic acid 
• 4068-76-2 5-bromo-2-hydroxy-benzoic acid methyl ester 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 69-72-7 salicylic acid 
• 50-78-2 aspirin 
• 108-95-2 phenol 
• 364323-77-3 2-(4-bromophenoxy)benzaldehyde 
• 552-89-6 2-nitro-benzaldehyde 
• 446-52-6 2-Fluorobenzaldehyde 
• 146328-85-0 5-bromo-2-fluoro-benzoic acid 
• 69199-84-4 2-phenoxy-5-bromobenzoic acid 
• 139139-81-4 bis(4-bromophenyl)iodonium triflate 

Downstream Products

• 40102-85-0 2,7-dibromo-9H-xanthen-9-one 
• 1166397-96-1 2-(2,6-dimethylphenyl)-9H-xanthen-9-one 
• 1316277-17-4 C₁₃H₈BrNO₂ 
• 1316277-23-2 C₁₃H₈BrNO₂ 
• 1316277-24-3 C₁₉H₁₃NO₂ 
• 1316277-18-5 C₁₉H₁₃NO₂ 
• 1316277-21-0 3-[2'-hydroxy-4'-bromophenyl]-5-bromo-1,2-benzisoxazole 
• 1316277-22-1 3-[2'-hydroxy-4'-phenylphenyl]-5-phenyl-1,2-benzisoxazole 
• 1316277-30-1 C₁₃H₈BrNO₃ 
• 1316277-35-6 C₁₃H₈BrNO₃ 
• 1316277-36-7 C₁₉H₁₃NO₃ 
• 1316277-31-2 C₁₉H₁₃NO₃ 
• 1316277-33-4 3-[2'-hydroxy-4'-bromophenyl]-5-bromo-1,2-benzisoxazole 2-oxide 
• 1316277-34-5 3-[2'-hydroxy-4'-phenylphenyl]-5-phenyl-1,2-benzisoxazole 2-oxide 

Relevant articles and documents

Synthesis of xanthones from 4-(2-phenoxyphenyl)-1-tosyl-1H-1,2,3-triazole via rhodium-catalyzed annulation/oxidation

A series of xanthone derivatives were synthesized by rhodium-catalyzed cycloaddition and sequential oxidation. The derivatives synthesized for excellent yields, including electron-withdrawing and electron-donating substituents, demonstrated the wide applicability of the proposed approach. The xanthones synthesized with different substituent electron effects may go through the same intermediate via two cycloadditions. It is highlighted that the protocol was exemplified by its successful integration into a one-pot synthesis directly from 1-ethynyl-2-phenoxybenzene. We believe that the current method may be an attractive option for the synthesis of xanthone and its derivatives.

Regioselective Bromine/Magnesium Exchange for the Selective Functionalization of Polyhalogenated Arenes and Heterocycles

Using the bimetallic combination sBu2Mg?2 LiOR (R=2-ethylhexyl) in toluene enables efficient and regioselective Br/Mg exchanges with various dibromo-arenes and -heteroarenes under mild reaction conditions and provides bromo-substituted magnesiu

Synthesis of xanthones, thioxanthones and Acridones by a metal-free photocatalytic oxidation using visible light and molecular oxygen

9H-Xanthenes, 9H-thioxanthenes and 9,10-dihydroacridines can be easily oxidized to the corresponding xanthones, thioxanthones and acridones, respectively, by a simple photo-oxidation procedure carried out using molecular oxygen as oxidant under the irradiation of visible blue light and in the presence of riboflavin tetraacetate as a metal-free photocatalyst. The obtained yields are high or quantitative.