17607-80-6

Basic information

• Product Name: 5-methyl-1-(phenylmethyl)-1H-Pyrazole-3-carboxylic acid
• Synonyms: 5-methyl-1-(phenylmethyl)-1H-Pyrazole-3-carboxylic acid;1-benzyl-5-methylpyrazole-3-carboxylic acid;1H-Pyrazole-3-carboxylic acid, 5-methyl-1-(phenylmethyl)-
• CAS NO: 17607-80-6
• Molecular Formula: C₁₂H₁₂N₂O₂
• Molecular Weight: 216.23588
• Mol File: 17607-80-6.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-methyl-1-(phenylmethyl)-1H-Pyrazole-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methyl-1-(phenylmethyl)-1H-Pyrazole-3-carboxylic acid(17607-80-6)
• EPA Substance Registry System: 5-methyl-1-(phenylmethyl)-1H-Pyrazole-3-carboxylic acid(17607-80-6)

Safety Data

• Hazardous Substances Data: 17607-80-6(Hazardous Substances Data)

Upstream product

• 80326-68-7 methyl 5-methyl-1-(phenylmethyl)-1H-pyrazole-3-carboxylate 
• 17607-81-7 ethyl 1-benzyl-5-methyl-1H-pyrazole-3-carboxylate 
• 615-79-2 ethyl 2,4-diketopentanoate 
• 555-96-4 Benzylhydrazine 
• 17607-79-3 ethyl 1-benzyl-3-methyl-1H-pyrazole-5-carboxylate 
• 20570-96-1 benzylhydrazine dihydrochloride 
• 20577-61-1 methyl 2,4-dioxopentanoate 
• 100-39-0 benzyl bromide 
• 4027-57-0 ethyl 5-methyl-2H-pyrazole-3-carboxylate 

Downstream Products

• 86327-93-7 1-benzyl-5-methylpyrazole 
• 916973-99-4 1-benzyl-5-methyl-1H-pyrazole-3-carboxylic acid methoxymethylamide 
• 916973-98-3 2-benzyl-5-methyl-2H-pyrazole-3-carboxylic acid methoxymethylamide 
• 916974-01-1 1-(1-benzyl-5-methyl-2H-pyrazol-3-yl)ethanone 

Relevant articles and documents

Novel Compounds

The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C- terminal hydrolase 30 or Ubiquitin Specific Peptidase 30 (USP30). The invention further relates to the use of DUB inhibitors in the treatment of conditions involving mitochondrial dysfunction and cancer. Compounds of the invention include compounds having the formula (I): (I) or a pharmaceutically acceptable salt thereof, wherein R1a, R1b, R1c, R1d, R1e, R1f, R1g, R2, X, L and A are as defined herein.

TRICYCLIC FUSED INDOLE DERIVATIVES AND THEIR USE AS AURORA KINASE INHIBITORS

Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them an

Pyrazolecarboxamide human neuropeptide Y5 receptor ligands with in vivo antifeedant activity

1-Aryl-3-carboxamido-5-alkylpyrazoles were prepared based on a hit found in high-throughput screening of our corporate compound library in an assay measuring affinity for the human neuropeptide Y5 receptor. 1-(3-Trifluoromethylphenyl)-3-[N-(5-quinolinyl)carboxamido]-5-methylpyrazole (31) bound to the human neuropeptide Y5 receptor with a 80 nM IC50and was shown to inhibit cumulative food consumption 43.2% 2-6 h after ip dosing in a fasting-induced feeding model in rats.