86327-93-7Relevant articles and documents
Aqueous N-methylmorpholine N-oxide as a new medium for alkylation of pyrazoles
Hasratyan, Ani H.,Alexanyan, Ashkharuhi G.,Khachatryan, Hasmik N.,Zakaryan, Geghetsik B.,Hayotsyan, Sargis S.,Danagulyan, Gevorg G.,Attaryan, Hovhannes S.
, p. 751 - 754 (2018/09/19)
[Figure not available: see fulltext.] It is shown that alkylation of pyrazoles with (E)/(Z)-1,3-dichlorobut-2-enes can be carried out in an alkaline aqueous medium in the presence of N-methylmorpholine N-oxide. In some cases, this technique may substitute
Quaternization and dequaternization of pyrazoles in solvent- free conditions: Conventional heating versus microwave irradiation
Diez-Barra, Enrique,De La Hoz, Antonio,Sanchez-Migallon, Ana,Elguero, Jose
, p. 889 - 894 (2007/10/03)
We report a study on the quaternization and dequaternization of pyrazoles by conventional heating and microwave irradiation in solvent-free conditions. Microwave irradiation produces an acceleration in the quaternization rate and a rapid equilibration between quaternized and non quaternized products. Dequaternization is also more rapid and a change on the selectivity is observed using symmetric pyrazolium salts.
Rearrangement of N-(Alkylamino)azoles in Acid Media: A New Entry to C-Amino-N-substituted Azoles
Salazar, Loreto,Espada, Modesta,Avendano, Carmen,Claramunt, Rosa Maria,Sanz, Dionisia,Elguero, Jose
, p. 1563 - 1567 (2007/10/02)
A ring-opening / ring-closure mechanism for the thermal rearrangement of 1-(alkylamino)pyrazoles into 5-amino-1-alkylpyrazoles in acid medium has been established. 1-(Benzylamino)pyrazoles show a different reactivity, affording bis(5-amino-1-benzyl-4-pyrazolyl)phenylmethanes.The reaction was extended to 1-(alkylamino)indazoles but failed in the case of 1-(alkylamino)-1,2,4-triazoles.
