176387-49-8

Basic information

• Product Name: (S)-1-(4-Hydroxy-5-methoxy-2-nitro-thiobenzoyl)-pyrrolidine-2-carbothioaldehyde
• CAS NO: 176387-49-8
• Molecular Weight: 326.397
• Mol File: 176387-49-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-1-(4-Hydroxy-5-methoxy-2-nitro-thiobenzoyl)-pyrrolidine-2-carbothioaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-(4-Hydroxy-5-methoxy-2-nitro-thiobenzoyl)-pyrrolidine-2-carbothioaldehyde(176387-49-8)
• EPA Substance Registry System: (S)-1-(4-Hydroxy-5-methoxy-2-nitro-thiobenzoyl)-pyrrolidine-2-carbothioaldehyde(176387-49-8)

Safety Data

• Hazardous Substances Data: 176387-49-8(Hazardous Substances Data)

Upstream product

• 175409-49-1 methyl-(2S)-N-[4-hydroxy-5-methoxy-2-nitrobenzoyl]pyrrolidine-2-carboxylate 
• 176387-47-6 (S)-1-(4-Hydroxy-5-methoxy-2-nitro-benzoyl)-pyrrolidine-2-carboxylic acid 
• 140647-01-4 4-hydroxy-5-methoxy-2-nitrobenzoic acid 
• 182277-06-1 4-Hydroxy-5-methoxy-2-nitro-benzoyl chloride 
• 175409-51-5 (S)-1-(4-Hydroxy-5-methoxy-2-nitro-benzoyl)-pyrrolidine-2-carbaldehyde 

Relevant articles and documents

A new facile procedure for the preparation of pyrrolo[2,1-c][1,4]benzodiazepines : Synthesis of the antibiotic DC-81 and its thio analogue

An efficient synthesis of the imine form of the pyrrolo[2,1-c][1,4] benzodiazepine ring system based on a new reductive cyclization procedure is described. The naturally occuring antibiotic DC-81(5c) and its 5-thio analogue (7c) have also been synthesized to illustrate the usefulness of this methodology.