175409-49-1Relevant articles and documents
Design and synthesis of C-8 linked pyrrolobenzodiazepine-naphthalimide hybrids as anti-tumour agents
Kamal, Ahmed,Reddy,Reddy, G.Suresh Kumar,Ramesh
, p. 1933 - 1935 (2007/10/03)
The facile synthesis of C-8 linked pyrrolobenzodiazepine-naphthalimide hybrid analogues is described. The compounds are prepared with varying degrees of linker length in order to probe the structural requirements for optimal in vitro anti-tumour activity. Some of these new hybrid compounds showed higher cytotoxic activity than the existing natural and synthetic pyrrolo[2,1-c][1,4]benzodiazepines.
Synthesis of novel non-cross-linking pyrrolobenzodiazepines with remarkable DNA binding affinity and potent antitumour activity
Kamal,Laxman,Ramesh,Neelima,Kondapi
, p. 437 - 438 (2007/10/03)
Mixed imine-amide pyrrolobenzodiazepine dimers have been prepared which exhibit potent antitumour activity and have significant DNA binding affinity; one of them, 1c, has been shown to cause a remarkable rise in the melting temperature of calf thymus DNA.
Synthesis of pyrrolo[2,1-c][1,4]benzodiazepine antibiotics: Oxidation of cyclic secondary amine with TPAP
Kamal, Ahmed,Howard, Philip W.,Reddy, B.S. Narayan,Reddy, B.S. Praveen,Thurston, David E.
, p. 3223 - 3230 (2007/10/03)
A facile procedure for the preparation of the imine form of the pyrrolo(2,1-c][1,4]-benzodiazepine ring system by the oxidation of eyelid secondary amine with catalytic amounts of tetra-n-propylammonium perruthenate (TPAP) and N-methylmorpholine N-oxide (NMO) as a co-oxidant is described. This oxidative method is devoid of side-products and is thus a significant improvement over the Swern oxidation previously reported.