64154-79-6

Basic information

• Product Name: L-Proline, 1-[5-methoxy-2-nitro-4-(phenylmethoxy)benzoyl]-
• CAS NO: 64154-79-6
• Molecular Formula: C20H20N2O7
• Molecular Weight: 400.388
• Mol File: 64154-79-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: L-Proline, 1-[5-methoxy-2-nitro-4-(phenylmethoxy)benzoyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Proline, 1-[5-methoxy-2-nitro-4-(phenylmethoxy)benzoyl]-(64154-79-6)
• EPA Substance Registry System: L-Proline, 1-[5-methoxy-2-nitro-4-(phenylmethoxy)benzoyl]-(64154-79-6)

Safety Data

• Hazardous Substances Data: 64154-79-6(Hazardous Substances Data)

Upstream product

• 64154-78-5 4-benzyloxy-5-methoxy-2-nitrobenzoyl chloride 
• 147-85-3 L-proline 
• 100-44-7 benzyl chloride 
• 1486-53-9 4-(benzyloxy)-3-methoxybenzoic acid 
• 121-34-6 3-methoxy-4-hydroxybenzoic acid 

Downstream Products

• 127810-77-9 (2S)-N-[4-benzyloxy-5-methoxy-2-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethyl dithioacetal 
• 140647-02-5 (2S)-N-(4-hydroxy-5-methoxy-2-nitrobenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetal 
• 140693-22-7 (S)-1-(4-(benzyloxy)-5-methoxy-2-nitrobenzoyl)pyrrolidine-2-carbaldehyde 
• 175409-49-1 methyl-(2S)-N-[4-hydroxy-5-methoxy-2-nitrobenzoyl]pyrrolidine-2-carboxylate 
• 482378-36-9 1-{4-[3-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-propoxy]-5-methoxy-2-nitro-benzoyl}-pyrrolidine-2-carboxylic acid methyl ester 
• 482378-37-0 1-{4-[4-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-butoxy]-5-methoxy-2-nitro-benzoyl}-pyrrolidine-2-carboxylic acid methyl ester 
• 482378-31-4 2-(3-{5-amino-4-[2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-propyl)-benzo[de]isoquinoline-1,3-dione 
• 482378-38-1 1-{4-[5-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-pentyloxy]-5-methoxy-2-nitro-benzoyl}-pyrrolidine-2-carboxylic acid methyl ester 
• 482378-25-6 2-(3-{4-[2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-propyl)-benzo[de]isoquinoline-1,3-dione 
• 482378-32-5 2-(4-{5-amino-4-[2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-butyl)-benzo[de]isoquinoline-1,3-dione 
• 482378-26-7 2-(4-{4-[2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-butyl)-benzo[de]isoquinoline-1,3-dione 
• 482378-33-6 2-(5-{5-amino-4-[2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-pentyl)-benzo[de]isoquinoline-1,3-dione 
• 482378-28-9 2-(5-{4-[2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-pentyl)-benzo[de]isoquinoline-1,3-dione 
• 482378-34-7 2-(8-{5-amino-4-[2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-phenoxy}-octyl)-benzo[de]isoquinoline-1,3-dione 

Relevant articles and documents

Design and synthesis of C-8 linked pyrrolobenzodiazepine-naphthalimide hybrids as anti-tumour agents

The facile synthesis of C-8 linked pyrrolobenzodiazepine-naphthalimide hybrid analogues is described. The compounds are prepared with varying degrees of linker length in order to probe the structural requirements for optimal in vitro anti-tumour activity. Some of these new hybrid compounds showed higher cytotoxic activity than the existing natural and synthetic pyrrolo[2,1-c][1,4]benzodiazepines.

New approaches to pyrrolo[2,1-c][1,4]benzodiazepines: Synthesis, DNA-binding and cytotoxicity of DC-81

Two routes to the naturally occuring DNA-binding antitumor antibiotic DC-81 are described, one of which involves a novel cyclization process based on acid resin. The second route involves the synthesis of a new compound, 6-nitrovanillic acid, a key A-ring component of many naturally occuring PBDs. These routes have provided a sufficient quantity of DC-81 to allow complete characterization and evaluation in DNA-binding and in vitro cytoxicity studies.