176859-85-1

Basic information

• Product Name: 3-(dimethylamino)-1-(2-nitrophenyl)propan-1-one
• Synonyms: 3-(dimethylamino)-1-(2-nitrophenyl)propan-1-one
• CAS NO: 176859-85-1
• Molecular Weight: 222.244
• Mol File: 176859-85-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3-(dimethylamino)-1-(2-nitrophenyl)propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(dimethylamino)-1-(2-nitrophenyl)propan-1-one(176859-85-1)
• EPA Substance Registry System: 3-(dimethylamino)-1-(2-nitrophenyl)propan-1-one(176859-85-1)

Safety Data

• Hazardous Substances Data: 176859-85-1(Hazardous Substances Data)

Upstream product

• 577-59-3 2-acetylnitrobenzene 
• 506-59-2 N,N-dimethylammonium chloride 
• 50-00-0 formaldehyd 
• 124-40-3 dimethyl amine 

Downstream Products

• 32690-76-9 3-morpholin-4-yl-1-(2-nitro-phenyl)-propan-1-one 
• 131620-12-7 2-[3-(2-amino-phenyl)-3-oxo-propyl]-1,1-dioxo-1λ⁶-benz[d]isothiazol-3-one 
• 363-36-0 kynuramine 
• 856633-77-7 2-[3-(2-nitro-phenyl)-3-oxo-propyl]-1,1-dioxo-1λ⁶-benz[d]isothiazol-3-one 
• 85888-68-2 1-(2-amino-phenyl)-3-dimethylamino-propan-1-one 

Relevant articles and documents

Pyrano[2,3,4-cd]indole as a Scaffold for Selective Nonbasic 5-HT6R Ligands

In this letter, we report the synthesis of a pyrano[2,3,4-cd]indole chemical scaffold designed through a tandem bioisostere generation/virtual screening protocol in search of 5-HT6R ligands. The discovered chemical scaffold resulted in the design of highly active basic and nonbasic 5-HT6R ligands (5-HT6R Ki = 1 nM for basic compound 6b and 5-HT6R Ki = 4 nM for its neutral analog 7b). Additionally, molecular modeling suggested that the hydroxyl group of nonbasic ligands 7a-7d forms hydrogen bonds with aspartic acid D3×32 or D7.36×35

Design of tRNALys3 Ligands: Fragment evolution and linker selection guided by NMR spectroscopy

A fragment-based approach for the synthesis of ligands of tRNA Lys3, the HIV reverse-transcription primer, is described. The use of NMR spectroscopy has proved to be very useful in this approach, not only to detect lowaffinity complexes between small compounds and RNA, but also to provide information on their binding mode and on the way they can be connected. This NMR-spectroscopy-guided analysis enabled us to design micromolar ligands after the optimisation and connection of millimolar fragments with an appropriate linker. The influence of the linker region on the binding affinity and selectivity outlines the importance of having a flexible assemblage strategy with a variety of linkers in such an approach. 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

Hypolipidemic activity of 3-amino-1-(2,3,4-mononitro-, mono-, or dihalophenyl) propan-1-ones in rodents

A series of 3-amino-1-(2,3,4-mononitro-, mono-, or dihalophenyl) propan-1-ones were synthesized and shown to be effective in lowering both serum cholesterol and triglyceride levels significantly in CF1 mice and Sprague-Dawley rats. All analogs