177167-79-2Relevant articles and documents
Platelet activating factor derivative and synthesis method thereof
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, (2017/08/29)
The invention belongs to the technical field of chemical synthesis and discloses a platelet activating factor derivative with a formula (I) structure, wherein a substituent group R refers to an acryl group. A synthetic route includes nine-step reaction by taking chiral source S-configuration solketal as a starting reactant. The method is adopted for synthesis of a 2-sulfo platelet activating factor and a derivative thereof for the first time and has advantages of high yield, easiness in separation and the like. Low-cost batch synthesis of 2-S-PAF and the derivative thereof is realized, and significances to activity research of 2-S-PAF and the derivative thereof, biological experiments, clinical application and disease treatment are achieved.