177492-52-3

Basic information

• Product Name: 1,3-BENZOXAZOL-6-AMINE
• Synonyms: 6-AMINO-BENZOXAZOLE;1,3-BENZOXAZOL-6-AMINE;Benzooxazol-6-ylamine;benzo[d]oxazol-6-amine;6-Amino-1,3-benzoxazole;6-BenzoxazolaMine
• CAS NO: 177492-52-3
• Molecular Formula: C₇H₆N₂O
• Molecular Weight: 134.14
• Mol File: 177492-52-3.mol
• Article Data: 9

Chemical Properties

• Melting Point: 88 °C
• Boiling Point: 282.296 °C at 760 mmHg
• Flash Point: 124.528 °C
• Appearance: Orange to brown/Solid
• Density: 1.317 g/cm³
• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.685
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Water Solubility: Slightly soluble in water.
• Sensitive: Air Sensitive
• CAS DataBase Reference: 1,3-BENZOXAZOL-6-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-BENZOXAZOL-6-AMINE(177492-52-3)
• EPA Substance Registry System: 1,3-BENZOXAZOL-6-AMINE(177492-52-3)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38-36-22
• Safety Statements: 22-26-36/37/39
• RIDADR: 2811
• HazardClass: IRRITANT
• Hazardous Substances Data: 177492-52-3(Hazardous Substances Data)

Usage

Uses

6-Aminobenzoxazole is used as pharmaceutical intermediate.

InChI:InChI=1/C7H6N2O/c8-5-1-2-6-7(3-5)10-4-9-6/h1-4H,8H2

Upstream product

• 17200-30-5 6-nitrobenzo[d]oxazole 
• 121-88-0 5-Nitro-2-aminophenol 

Downstream Products

• 1264926-93-3 N-(5-(benzyloxy)-6-p-tolylpyrimidin-4-yl)benzo[d]oxazol-6-amine 
• 1332392-79-6 5-(5-(4-amino-3-hydroxyphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinonitrile 

Relevant articles and documents

Gould-jacobs reaction of 5- and 6-amino-2-substituted benzoxazoles. II. Reaction with 3-ethoxymethylene-2,4-pentanedione and ethyl 2-ethoxymethylene-3-oxobutanoate

Nucleophilic reaction of 5-amino- and 6-amino-2-substituted benzoxazoles 1 and 2 with 3-ethoxymethylene-2,4-pentanedione (3) gave compounds 5 and 6. Compounds 1 and 2 reacted with ethyl ethoxymethylene-3-oxobutanoate (4) under formation of compounds 7 and

Highly efficient Ir-catalyzed asymmetric hydrogenation of benzoxazinones and derivatives with a Br?nsted acid cocatalyst

The Ir-catalyzed highly efficient asymmetric hydrogenation of benzoxazinones and derivatives was successfully developed with N-methylated ZhaoPhos L5 as the ligand, which may display a new activation mode with a single anion-binding interaction among the

Nitrogen-doped graphene-activated iron-oxide-based nanocatalysts for selective transfer hydrogenation of nitroarenes

Nanoscaled iron oxides on carbon were modified with nitrogen-doped graphene (NGr) and found to be excellent catalysts for the chemoselective transfer hydrogenation of nitroarenes to anilines. Under standard reaction conditions, a variety of functionalized and structurally diverse anilines, which serve as key building blocks and central intermediates for fine and bulk chemicals, were synthesized in good to excellent yields.

Synthesis and broad-spectrum antiviral activity of some novel benzo-heterocyclic amine compounds

A series of novel unsaturated five-membered benzo-heterocyclic amine derivatives were synthesized and assayed to determine their in vitro broad-spectrum antiviral activities. The biological results showed that most of our synthesized compounds exhibited potent broad-spectrum antiviral activity. Notably, compounds 3f (IC50 = 3.21-5.06 M) and 3g (IC50 = 0.71-34.87 M) showed potent activity towards both RNA viruses (influenza A, HCV and Cox B3 virus) and a DNA virus (HBV) at low micromolar concentrations. An SAR study showed that electron-withdrawing substituents located on the aromatic or heteroaromatic ring favored antiviral activity towards RNA viruses.