17200-30-5

Basic information

• Product Name: 6-NITRO-1,3-BENZOXAZOLE
• Synonyms: 6-NITRO BENZOXAZOLONE;6-NITRO-1,3-BENZOXAZOLE;6-Nitrobenzo[d]oxazole;6-Nitro-benzooxazole;6-Nitrobenzoxazole
• CAS NO: 17200-30-5
• Molecular Formula: C₇H₄N₂O₃
• Molecular Weight: 164.12
• EINECS: 200-258-5
• Mol File: 17200-30-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 150-152°
• Boiling Point: 294.2 °C at 760 mmHg
• Flash Point: 131.7 °C
• Appearance: /
• Density: 1.473g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: -2.05±0.30(Predicted)
• CAS DataBase Reference: 6-NITRO-1,3-BENZOXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-NITRO-1,3-BENZOXAZOLE(17200-30-5)
• EPA Substance Registry System: 6-NITRO-1,3-BENZOXAZOLE(17200-30-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 17200-30-5(Hazardous Substances Data)

Usage

General Description

6-Nitro-1,3-benzoxazole is a chemical compound with the molecular formula C7H4N2O3. It is a nitro benzoxazole derivative with a nitro group (-NO2) attached to the 6th carbon atom of the benzoxazole ring. 6-Nitro-1,3-benzoxazole is often used as a starting material in the synthesis of various organic compounds and pharmaceuticals due to its unique chemical reactivity and structural properties. Additionally, it has potential applications in the field of material science, as it can be used in the production of advanced materials such as polymers, dyes, and fluorescent compounds. 6-Nitro-1,3-benzoxazole is also of interest to researchers due to its biological activity, and there is ongoing investigation into its potential use in drug development and medicinal chemistry. However, it is important to handle this compound with care, as it is considered hazardous and may pose health risks if not used properly.

InChI:InChI=1/C7H5N2O3/c10-9(11)5-1-2-6-7(3-5)12-4-8-6/h1-4H,(H,10,11)

Upstream product

• 273-53-0 benzoxazole 
• 122-51-0 orthoformic acid triethyl ester 
• 121-88-0 5-Nitro-2-aminophenol 
• 149-73-5 trimethyl orthoformate 

Downstream Products

• 169181-43-5 1-chloro-2-<(2-hydroxy-4-nitrophenyl)amino>ethenyl-p-tolyl sulfone 
• 70886-36-1 N-(2-hydroxy-4-nitrophenyl)formamide 
• 121-88-0 5-Nitro-2-aminophenol 
• 177492-52-3 MFCD 03791187 
• 72206-96-3 6-nitro-7-(2-phenylethyl)benzoxazole 
• 39835-14-8 2-hydroxy-4-nitro-benzonitrile 
• 1361119-39-2 6-nitro-N-(1-phenylethyl)benzo[d]oxazol-2-amine 
• 58758-40-0 2-(4-methylphenyl)-6-nitrobenzoxazole 
• 3164-28-1 6-nitro-2-phenylbenzo[d]oxazole 

Relevant articles and documents

Method for synthesizing benzoxazole through microwave radiation of benzamide compound in water phase

The invention discloses a method for synthesizing benzoxazole through microwave radiation of a benzamide compound in a water phase. The benzamide compound is added into the water phase under the microwave condition to be subjected to a cyclization reaction for generating the benzoxazole under the alkali condition, and the method for preparing the benzoxazole is environmentally friendly, easy and convenient to operate, safe, low in cost and efficient. Compared with the prior art, the method can be applied to a large number of functional groups, the yield is high, the number of by-products is small, and the method is easy to operate, safe, low in cost and environmentally friendly. (Please see the specifications for the formula).

ANTI-INFECTIVE COMPOUNDS

The present invention relates to small molecule compounds having the general formula (I): wherein A is a moiety selected from the group consisting of formulae (A) to (K) and their use in the treatment of bacterial infections, in particular Tuberculosis.

Iodine-mediated arylation of benzoxazoles with aldehydes

A simple and efficient methodology for the arylation of benzoxazoles with aldehydes using iodine as the mediator has been developed. The reaction proceeded smoothly with a range of substrates to give the corresponding arylated products in moderate to good yields.