177532-24-0

Basic information

• Product Name: (R)-2-Hydroxymethyl-2-phenyl-butyric acid methyl ester
• Synonyms: (R)-2-Hydroxymethyl-2-phenyl-butyric acid methyl ester
• CAS NO: 177532-24-0
• Molecular Weight: 208.257
• Mol File: 177532-24-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-2-Hydroxymethyl-2-phenyl-butyric acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-Hydroxymethyl-2-phenyl-butyric acid methyl ester(177532-24-0)
• EPA Substance Registry System: (R)-2-Hydroxymethyl-2-phenyl-butyric acid methyl ester(177532-24-0)

Safety Data

• Hazardous Substances Data: 177532-24-0(Hazardous Substances Data)

Upstream product

• 88254-02-8 (R)-2-Ethyl-2-phenyl-malonic acid monomethyl ester 
• 88253-95-6 dimethyl 2-ethyl-2-phenylmalonate 
• 2613-89-0 phenylmalonic acid 
• 1636-25-5 (ethyl)phenylmalonic acid 
• 177532-30-8 (S)-2-Methoxycarbonyloxycarbonyl-2-phenyl-butyric acid methyl ester 

Downstream Products

• 17575-59-6 glutethimide 
• 170450-73-4 (S)-(+)-2-ethyl-2-phenylglutaric acid 
• 177532-26-2 (S)-(+)-5-ethyl 1-methyl 2-ethyl-2-phenylglutarate 
• 177532-29-5 (S)-(+)-4-ethyl-4-phenylpent-2-enedioic acid 1-ethyl ester 5-methyl ester 
• 177532-28-4 methyl (R)-(+)-2-formyl-2-phenylbut-3-enoate 

Relevant articles and documents

Asymmetric construction of benzylic quaternary carbons from chiral malonates: Formal synthesis of both (-)- and (+)-aminoglutethimides AG and analogues

From a single chiron (R)-(+)-5, available with high enantiomeric excess (97%) by enzymatic hydrolysis (PLE acetonic powder) of a malonate, were prepared convenient precursors of aminoglutethimides (-)-AG-1 and (+)-AG-1. This versatile method also allows preparation of the b-hydroxy ester (R)-9 and its enantiomer (S)-9 as well as the glutethimides (S)-4 and (R)-4 and other analogues.