17575-59-6

Basic information

• Product Name: 2,6-Piperidinedione, 3-ethyl-3-phenyl-, (3S)-
• CAS NO: 17575-59-6
• Molecular Formula: C13H15NO2
• Molecular Weight: 217.268
• Mol File: 17575-59-6.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: 2,6-Piperidinedione, 3-ethyl-3-phenyl-, (3S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Piperidinedione, 3-ethyl-3-phenyl-, (3S)-(17575-59-6)
• EPA Substance Registry System: 2,6-Piperidinedione, 3-ethyl-3-phenyl-, (3S)-(17575-59-6)

Safety Data

• Hazardous Substances Data: 17575-59-6(Hazardous Substances Data)

Upstream product

• 100393-27-9 3-phenyl-3-vinyl-piperidine-2,6-dione 
• 17721-16-3 4-cyano-4-phenylhexanoic acid 
• 769-68-6 2-phenylbutanenitrile 
• 24131-07-5 methyl 2-cyano-2-phenylbutanoate 
• 66003-76-7 Diphenyliodonium triflate 
• 77-21-4 Glutethimide 
• 74220-50-1 2-ethyl-2-phenylglutarodinitrile 
• 88254-02-8 (R)-2-Ethyl-2-phenyl-malonic acid monomethyl ester 
• 177532-24-0 (R)-2-Hydroxymethyl-2-phenyl-butyric acid methyl ester 
• 177532-30-8 (S)-2-Methoxycarbonyloxycarbonyl-2-phenyl-butyric acid methyl ester 
• 177532-29-5 (S)-(+)-4-ethyl-4-phenylpent-2-enedioic acid 1-ethyl ester 5-methyl ester 
• 177532-28-4 methyl (R)-(+)-2-formyl-2-phenylbut-3-enoate 
• 88253-95-6 dimethyl 2-ethyl-2-phenylmalonate 
• 2613-89-0 phenylmalonic acid 

Downstream Products

• 17575-40-5 3-ethyl-1-methyl-3-phenyl-piperidine-2,6-dione 
• 52650-09-6 3-ethyl-3-phenyl-6-thioxo-piperidin-2-one 
• 56037-73-1 5-bromo-3-ethyl-3-phenyl-piperidine-2,6-dione 
• 38527-74-1 o-Nitroglutethimide 
• 38527-73-0 rac-3-ethyl-3-(4-nitrophenyl)piperidine-2,6-dione 
• 129224-50-6 2-[5-Ethyl-6-oxo-5-phenyl-piperidin-(2Z)-ylidene]-propionic acid tert-butyl ester 
• 129242-19-9 [5-Ethyl-6-oxo-5-phenyl-piperidin-(2Z)-ylidene]-acetic acid tert-butyl ester 
• 61327-85-3 1-(2-chloro-ethyl)-3-ethyl-3-phenyl-piperidine-2,6-dione 
• 73252-00-3 3-ethyl-3-(3'-nitrophenyl)piperidine-2,6-dione 
• 83435-77-2 4-phenyl-4-carboxamidohexanoic acid hydrazide 
• 17575-58-5 glutethimide 
• 59453-51-9 3-ethyl-3-(2',4'-dinitrophenyl)-piperidine-2,6-dione 
• 15025-15-7 ω-Hydroxy-α-ethyl-α-phenyl-valeramid-p-nitrobenzoat 

Relevant articles and documents

Method for asymmetric catalytic synthesis of gamma-cyanoamide compound and chiral drug using gamma-cyanoamide compound

The invention relates to a method for asymmetric catalytic synthesis of a gamma-cyanoamide compound and a chiral drug using the gamma-cyanoamide compound. The method specifically comprises the following step: with silicon group-protected allene ketimine and alpha,beta-unsaturated pyrazolecarboxamide as raw materials, a complex formed by chiral amine oxide and cobalt trifluoromethanesulfonate as a catalyst, water as an additive, and trichloromethane as a solvent, conducting reacting for 2 to 48 hours at 0 to -60 DEG C so as to obtain the chiral gamma-cyanopyrazolecarboxamide compound which is high in property and good in substrate universality. A plurality of chiral natural products or drug molecules such as verapamil, Sporochnol A and key intermediates for synthesizing Epilarene, Aphanorphine and Ammoglutethimide can be obtained by performing some simple conversion on the catalytic product, namely the gamma-cyanopyrazolecarboxamide compound.

Regiodivergent Copper Catalyzed Borocyanation of 1,3-Dienes

Copper catalyzed multi-functionalization of unsaturated carbon-carbon bonds is a powerful tool for the generation of complex molecules. We report a regiodivergent process that allows a switch between 1,4-borocupration and 4,1-borocupration of 1,3-dienes upon a simple change in ligand. The subsequently generated allyl coppers are trapped in an electrophilic cyanation to selectively generate densely functionalized and synthetically versatile 1,2- or 4,3-borocyanation products.

Tert-Butoxide-Mediated Arylation of 2-Substituted Cyanoacetates with Diaryliodonium Salts

A transition metal-free direct arylation of 2-substituted cyanoacetates with diaryliodonium salts was developed. With this approach, a wide range of α-tolunitrile derivatives has been synthesized in good to excellent yields of 45-92%. Furthermore, the practicability of this approach is further manifested in the synthesis of a related bioactive agent of glutarimide.