17575-58-5

Basic information

• Product Name: 2,6-Piperidinedione, 3-ethyl-3-phenyl-, (3R)-
• CAS NO: 17575-58-5
• Molecular Formula: C13H15NO2
• Molecular Weight: 217.268
• Mol File: 17575-58-5.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: 2,6-Piperidinedione, 3-ethyl-3-phenyl-, (3R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Piperidinedione, 3-ethyl-3-phenyl-, (3R)-(17575-58-5)
• EPA Substance Registry System: 2,6-Piperidinedione, 3-ethyl-3-phenyl-, (3R)-(17575-58-5)

Safety Data

• Hazardous Substances Data: 17575-58-5(Hazardous Substances Data)

Upstream product

• 77-21-4 Glutethimide 
• 100393-27-9 3-phenyl-3-vinyl-piperidine-2,6-dione 
• 769-68-6 2-phenylbutanenitrile 
• 107-13-1 acrylonitrile 
• 24131-07-5 methyl 2-cyano-2-phenylbutanoate 
• 66003-76-7 Diphenyliodonium triflate 
• 2288-18-8 2-phenyl-1,3-butadiene 
• 125-84-8 aminoglutethimide 
• 100723-78-2 2-phenyl-2-vinyl-glutaronitrile 
• 38586-17-3 2-phenyl-crotononitrile 
• 140-29-4 phenylacetonitrile 
• 74220-50-1 2-ethyl-2-phenylglutarodinitrile 
• 17721-16-3 4-cyano-4-phenylhexanoic acid 
• 170450-62-1 (3S,4R)-4-Hydroxy-5-oxo-3-phenyl-tetrahydro-furan-3-carboxylic acid ethyl ester 

Downstream Products

• 17575-40-5 3-ethyl-1-methyl-3-phenyl-piperidine-2,6-dione 
• 52650-09-6 3-ethyl-3-phenyl-6-thioxo-piperidin-2-one 
• 56037-73-1 5-bromo-3-ethyl-3-phenyl-piperidine-2,6-dione 
• 38527-74-1 o-Nitroglutethimide 
• 38527-73-0 rac-3-ethyl-3-(4-nitrophenyl)piperidine-2,6-dione 
• 15025-14-6 ω-Hydroxy-α-ethyl-α-phenyl-valeramid 
• 129224-50-6 2-[5-Ethyl-6-oxo-5-phenyl-piperidin-(2Z)-ylidene]-propionic acid tert-butyl ester 
• 129242-19-9 [5-Ethyl-6-oxo-5-phenyl-piperidin-(2Z)-ylidene]-acetic acid tert-butyl ester 
• 61327-85-3 1-(2-chloro-ethyl)-3-ethyl-3-phenyl-piperidine-2,6-dione 
• 73252-00-3 3-ethyl-3-(3'-nitrophenyl)piperidine-2,6-dione 
• 83435-77-2 4-phenyl-4-carboxamidohexanoic acid hydrazide 
• 17575-59-6 glutethimide 
• 170450-74-5 (R)-(+)-3-ethyl-3-(4-nitrophenyl)piperidine-2,6-dione 

Relevant articles and documents

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Enantioselective synthesis of nitriles containing a quaternary carbon center by michael reactions of silyl ketene imines with 1-acrylpyrazoles

The enantioselective construction of quaternary carbon centers is a marked challenge in asymmetric catalysis research. It is extremely difficult when a chiral catalyst can not distinguish the facial selectivity of the substrate through bond interactions. Here we realized an enantioselective Michael reaction of silyl ketene imines to 1-acrylpyrazoles using a chiral N,N′-dioxide-Co(II) complex. The protocol is highly efficient for the construction of nitrile-, aryl-, and dialkyl-bearing carbon centers and has been successful applied in the divergent synthesis of pharmaceuticals and natural products. The through-space dispersion interactions between unbound silyl ketene imines and the 1-acrylpyrazole-bonded catalyst play a key role in facilitating the reactivity and the enantioselectivity of this process.

Tert-Butoxide-Mediated Arylation of 2-Substituted Cyanoacetates with Diaryliodonium Salts

A transition metal-free direct arylation of 2-substituted cyanoacetates with diaryliodonium salts was developed. With this approach, a wide range of α-tolunitrile derivatives has been synthesized in good to excellent yields of 45-92%. Furthermore, the practicability of this approach is further manifested in the synthesis of a related bioactive agent of glutarimide.