177780-87-9

Basic information

• Product Name: 2-(hex-5-enyloxy)benzonitrile
• Synonyms: 2-(hex-5-enyloxy)benzonitrile
• CAS NO: 177780-87-9
• Molecular Weight: 201.268
• Mol File: 177780-87-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(hex-5-enyloxy)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(hex-5-enyloxy)benzonitrile(177780-87-9)
• EPA Substance Registry System: 2-(hex-5-enyloxy)benzonitrile(177780-87-9)

Safety Data

• Hazardous Substances Data: 177780-87-9(Hazardous Substances Data)

Upstream product

• 611-20-1 salicylonitrile 
• 64818-36-6 5-hexenyl methanesulfonate 
• 2695-47-8 6-Bromo-1-hexene 

Downstream Products

• 177780-92-6 2-(hex-5-enyloxy)benzylamine 

Relevant articles and documents

Synthesis of medium and large cyclic amines in rhodium-catalysed reactions of aminoalkenes with H2/CO1

Rhodium-catalysed reactions of N-benzyl- or N-alkyl-aminoalkenes (6) with H2/CO can give cyclic amines (7) (7-13 ring size) in good to excellent yields when BIPHEPHOS is used as a ligand. Hydrogenation of the aminoalkene becomes a competing reaction for the smaller rings but can be overcome by using a H2/CO gas ratio of 1:5. Reactions of 2-alkenyloxybenzylamines (13) gave 9-, 12- and 17-membered rings (14) in 30-40% yield, but dimer formation (16) and/or hydrogenation were competing reactions. Similar reactions of alkenylamides and ortho-alkenylanilines gave only non-cyclized amino aldehydes as products in low isolated yields.