178424-16-3Relevant articles and documents
Bone targeted drugs 2. Synthesis of estrogens with hydroxyapatite affinity
Willson, Timothy M.,Henke, Brad R.,Momtahen, Tanya M.,Garrison, Deanna T.,Moore, Linda B.,Geddie, Nora G.,Baer, Philip G.
, p. 1047 - 1050 (1996)
The utility of the bone targeting 4-carboxy-3-hydroxy-1,2-pyrazole heterocycle was tested by the synthesis of hybrids with the non-steroidal estrogen hexestrol. Compounds 1 and 2 demonstrated significant hydroxyapatite affinity, while maintaining weak estrogenic activity in whole cell assays. Copyright