178609-50-2

Basic information

• Product Name: ethyl 3-(4-(methoxymethoxy)phenyl)-3-oxopropanoate
• Synonyms: ethyl 3-(4-(methoxymethoxy)phenyl)-3-oxopropanoate
• CAS NO: 178609-50-2
• Molecular Weight: 252.267
• Mol File: 178609-50-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: ethyl 3-(4-(methoxymethoxy)phenyl)-3-oxopropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-(4-(methoxymethoxy)phenyl)-3-oxopropanoate(178609-50-2)
• EPA Substance Registry System: ethyl 3-(4-(methoxymethoxy)phenyl)-3-oxopropanoate(178609-50-2)

Safety Data

• Hazardous Substances Data: 178609-50-2(Hazardous Substances Data)

Upstream product

• 25458-44-0 4-(methoxymethoxy)benzoic acid 
• 6148-64-7 ethyl potassium malonate 
• 139884-19-8 4-(methoxymethoxy)benzoic acid methyl ester 
• 107-30-2 chloromethyl methyl ether 
• 99-93-4 4-Hydroxyacetophenone 
• 85699-00-9 1-[4-(methoxymethoxy)phenyl]-1-ethanone 
• 105-58-8 Diethyl carbonate 

Downstream Products

• 1415570-54-5 ethyl 8-(((benzyloxy)carbonyl)amino)-2-(4-(methoxymethoxy)phenyl)imidazo[1,2-a]pyridine-3-carboxylate 
• 1026047-38-0 4-Benzo[1,3]dioxol-5-yl-2-(4-methoxymethoxy-phenyl)-1-(2-propylamino-ethyl)-pyrrolidine-3-carboxylic acid ethyl ester 
• 1025941-73-4 4-Benzo[1,3]dioxol-5-yl-1-(2-bromo-ethyl)-2-(4-methoxymethoxy-phenyl)-pyrrolidine-3-carboxylic acid ethyl ester 
• 1026743-91-8 4-Benzo[1,3]dioxol-5-yl-2-(4-methoxymethoxy-phenyl)-4,5-dihydro-3H-pyrrole-3-carboxylic acid ethyl ester 

Relevant articles and documents

COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY

Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.

ENDOTHELIN ANTAGONISTS

A compound of the formula (I): STR1 or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.

Pyrrolidine-3-carboxylic acids as endothelin antagonists. 2. Sulfonamide-based ET(A)/ET(B) mixed antagonists

When the N,N-dialkylacetamide side chain of the highly ET(A)-selective endothelin antagonist ABT-627 (1; [2R,3R,4S]-2-(4-methoxyphenyl)-4-(1,3- benzodioxol-5-yl)-1-[[(N,N-dibutylamino)carbonyl]methyl]pyrrolidine-3- carboxylic acid; A-147627) is replaced by N,S-dialkylsulfonami-doethyl, the resultant analogs retain ET(A) affinity, but exhibit substantial ET(B) affinity as well. Structure-activity studies reveal that modifications in the length of the two alkyl groups, and in the substitution on the anisyl ring, are important in optimizing this 'balanced' antagonist profile. In particular the combination of an N-n-propyl group, an S-alkyl chain between four and six carbons in length, and a fluorine atom ortho to the aromatic OCH3 provides compounds with sub-nanomolar affinities for both receptor subtypes, and with ET(A)/ET(B) ratios close to 1. A number of these compounds also exhibit oral bioavailabilities (in rats) in the 30-50% range and have substantial plasma half-lives. The balanced receptor-binding profile of these potent and orally bioavailable compounds complements the ET(A) selectivity observed with 1.