17861-16-4

Basic information

• Product Name: Benzaldehyde, 2-hydroxy-4-methoxy-, oxime
• CAS NO: 17861-16-4
• Molecular Formula: C8H9NO3
• Molecular Weight: 167.164
• Mol File: 17861-16-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzaldehyde, 2-hydroxy-4-methoxy-, oxime(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 2-hydroxy-4-methoxy-, oxime(17861-16-4)
• EPA Substance Registry System: Benzaldehyde, 2-hydroxy-4-methoxy-, oxime(17861-16-4)

Safety Data

• Hazardous Substances Data: 17861-16-4(Hazardous Substances Data)

Upstream product

• 59648-29-2 2-hydroxy-4-methoxybenzyl alcohol 
• 95-01-2 2,4-Dihydroxybenzaldehyde 
• 673-22-3 2-Hydroxy-4-methoxybenzaldehyde 

Downstream Products

• 39835-11-5 2-hydroxy-4 methoxybenzonitrile 
• 1355024-87-1 1-tert-butyl 2-methyl 5-hydroxy-4-(2-hydroxy-4-methoxybenzyl)-5,6-dihydropyrazine-1,2(4H)-dicarboxylate 
• 164515-08-6 2-(aminomethyl)-5-methoxyphenol 
• 860562-27-2 2-(2,5-dimethoxy-3-methyl-phenoxy)-4-methoxy-benzoic acid 
• 860594-96-3 2-(2,5-dimethoxy-3-methyl-phenoxy)-4-methoxy-benzonitrile 
• 4107-65-7 2,4-dimethoxybenzonitrile 

Relevant articles and documents

Synthesis and SAR study of simple aryl oximes and nitrofuranyl derivatives with potent activity against Mycobacterium tuberculosis

Background: Oximes and nitrofuranyl derivatives are particularly important compounds in medicinal chemistry. Thus, many researchers have been reported to possess antibacterial, antiparasitic, insecticidal and fungicidal activities. Methods: In this work, we report the synthesis and the biological activity against Mycobacterium tuberculosis H37RV of a series of fifty aryl oximes, ArCH=N-OH, I, and eight nitrofuranyl compounds, 2-nitrofuranyl-X, II. Results: Among the oximes, I: Ar = 2-OH-4-OH, 42, and I: Ar = 5-nitrofuranyl, 46, possessed the best activity at 3.74 and 32.0 μM, respectively. Also, 46, the nitrofuran compounds, II; X = MeO, 55, and II: X = NHCH2Ph, 58, (14.6 and 12.6 μM, respectively), exhibited excellent biological activities and were non-cytotoxic. Conclusion: The compound 55 showed a selectivity index of 9.85. Further antibacterial tests were performed with compound 55 which was inactive against Enterococcus faecalis, Klebisiella pneumonae, Pseudomonas aeruginosa, Staphylococcus aureus, Salmonella typhymurium and Shigel-la flexneri. This study adds important information to the rational design of new lead anti-TB drugs. Structure-activity Relationship (SAR) is reported.

Calculation and experimental measurement of paramagnetic NMR parameters of phenolic oximate Cu(II) complexes

We present a strategy for predicting the unusual 1H and 13C shifts in NMR spectra of paramagnetic bisoximato copper(ii) complexes using DFT. We demonstrate good agreement with experimental measurements, although 1H-13C correlation spectra show that a combined experimental and theoretical approach remains necessary for full assignment.

NMR spectral assignment of substituted salicylaldoximes by inverse pulse techniques with z-gradient selection: Correlation of NMR parameters with substituent constants

1H and 13C and also 1H,13C HMQC and 1H,X HMBC (X = 13C and 15N) correlation maps with z-gradient selection of seven salicylaldoximes were recorded and assigned and their paramete