179178-38-2

Basic information

• Product Name: 3'-O-(4,4'-dimethoxytrityl)-5'-formylthymidine
• Synonyms: 3'-O-(4,4'-dimethoxytrityl)-5'-formylthymidine
• CAS NO: 179178-38-2
• Molecular Weight: 542.588
• Mol File: 179178-38-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3'-O-(4,4'-dimethoxytrityl)-5'-formylthymidine(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-O-(4,4'-dimethoxytrityl)-5'-formylthymidine(179178-38-2)
• EPA Substance Registry System: 3'-O-(4,4'-dimethoxytrityl)-5'-formylthymidine(179178-38-2)

Safety Data

• Hazardous Substances Data: 179178-38-2(Hazardous Substances Data)

Upstream product

• 50-89-5 thymidine 
• 164267-52-1 5'-O-tert-butyldimethylsilyl-3'-O-(4,4'-dimethoxytriphenylmethyl)thymidine 
• 40733-28-6 5'-tert-butyldimethylsilyloxy-2'-deoxythymidine 
• 76054-81-4 3'-O-(4,4'-dimethoxytrityl)thymidine 

Downstream Products

• 179178-49-5 N-[(2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-2,2,2-trifluoro-acetamide 
• 179178-43-9 5'-O-(4,4'-dimethoxytrityl)-4'-C-methoxymethylenethymidine 
• 183064-05-3 Benzoic acid (2S,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(tetrahydro-pyran-2-yloxy)-2-(tetrahydro-pyran-2-yloxymethyl)-tetrahydro-furan-2-ylmethyl ester 
• 183064-07-5 Benzoic acid (2R,3S,5R)-3-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 
• 179178-40-6 4'-C-benzoyloxymethylthymidine 

Relevant articles and documents

4′-Epi-DNA: A DNA Mimic Containing 4′-hydroxymethyl-α-l-Xylo-Thymidine with Compact Backbone like RNA

Synthesis of C4′-epi-DNA containing 3′→ 5″ linkages is reported for the first time. Crystal structure study of the monomer indicated that though the dihedral angle O3′-C3′-C4′-C5″ in this case would be like in RNA, the sugar conformation would remain like that in DNA. The study of the effect of this backbone configuration in DNA with respect to its binding to cDNA and RNA is reported in this note.

Synthesis and evaluation of oligodeoxynucleotides containing 4'-C-substituted thymidines

4'-C-Hydroxymethylthymidine was converted to 4'-C-methoxymethylthymidine and 4'-C-aminomethylthymidine, which were incorporated into oligodeoxynucleotides by phosphoramidite chemistry. The modified oligonucleotides exhibit excellent hybridization and significant improvement in stability to snake venom phosphodiesterase.