179983-39-2

Basic information

• Product Name: 1-methyl-4-[p-bis(2-chloroethyl)aminobenzamido]-imidazole-2-carboxylic acid
• Synonyms: 1-methyl-4-[p-bis(2-chloroethyl)aminobenzamido]-imidazole-2-carboxylic acid
• CAS NO: 179983-39-2
• Molecular Weight: 385.25
• Mol File: 179983-39-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-methyl-4-[p-bis(2-chloroethyl)aminobenzamido]-imidazole-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-4-[p-bis(2-chloroethyl)aminobenzamido]-imidazole-2-carboxylic acid(179983-39-2)
• EPA Substance Registry System: 1-methyl-4-[p-bis(2-chloroethyl)aminobenzamido]-imidazole-2-carboxylic acid(179983-39-2)

Safety Data

• Hazardous Substances Data: 179983-39-2(Hazardous Substances Data)

Upstream product

• 109012-23-9 ethyl 1-methyl-4-nitroimidazole-2-carboxylate 
• 128293-62-9 ethyl 4-amino-1-methylimidazole-2-carboxylate 
• 89088-57-3 ethyl 3-amino-1-methyl-1H-pyrazole-5-carboxylate 
• 15944-88-4 4-[N,N-bis(2-chloroethyl)amino]benzoyl chloride 
• 288625-59-2 ethyl 1-methyl-4-[p-bis(2-chloroethyl)aminobenzamido]-imidazole-2-carboxylate 

Relevant articles and documents

DNA sequence-recognizing properties of minor groove alkylating agents / Effects of the replacement of N-methylpyrrole by an N-methylimidazole on tallimustine and its own homologue

The linkage of an heterocycle, like N-methylimidazole, to minor DNA groove binders containing two or three pyrroles lead to a new class of oligopeptides with reduced antitumor activity both in vitro and in vivo if compared to tallimustine (CAS 115308-98-0) and its tetrapyrrole homologue 9. In the present paper is reported the correlation between the cytoxicity of tallimustine and its derivatives 9-11 with their ability to inhibit polymerase chain reaction (PCR) amplification of oestrogen receptor and Ha- ras gene sequences, containing A+T rich and G+C rich regions, respectively. Tallimustine and its tetrapyrrole homologue 9 were found to have higher sequence selectivity for the human oestrogen receptor (ER) gene with respect to the relative imidazole-containing analogues.