181116-74-5Relevant articles and documents
Synthesis, biological activity, and conformational analysis of four seco-D-15,19-bisnor-1α,25-dihydroxyvitamin D analogues, diastereomeric at C17 and C20
Zhou, Xiaoming,Zhu, Gui-Dong,Van Haver, Dirk,Vandewalle, Maurits,De Clercq, Pierre J.,Verstuyf, Annemieke,Bouillon, Roger
, p. 3539 - 3556 (2007/10/03)
The synthesis of four CD-ring-modified 19-nor-1α,25-dihydroxyvitamin D3 derivatives lacking C15, referred to as 6C analogues, and diastereomeric at C17 and C20 is described. The synthesis involves an Ireland-Claisen rearrangement of a 3-methyl-