181140-34-1 Usage
Description
(R)-(-)-GLYCIDYL PHTHALIMIDE, also known as (R)-N-Glycidylphthalimide, is a white solid reagent with significant applications in the pharmaceutical industry. It is characterized by its unique chemical structure, which allows for the simultaneous preparation of amino alcohol solvating agents and the synthesis of orally available anticoagulants.
Uses
Used in Pharmaceutical Industry:
(R)-(-)-GLYCIDYL PHTHALIMIDE is used as a reagent for the preparation of amino alcohol solvating agents, which are essential in the development of various pharmaceutical compounds. These agents play a crucial role in enhancing the solubility and bioavailability of drugs, thereby improving their overall effectiveness.
(R)-(-)-GLYCIDYL PHTHALIMIDE is also used as a reagent for the preparation of orally available anticoagulants. These anticoagulants are vital in the treatment and prevention of blood clots, which can lead to life-threatening conditions such as stroke and heart attack.
Additionally, (R)-(-)-N-(2,3-Epoxypropyl)phthalimide, a derivative of (R)-(-)-GLYCIDYL PHTHALIMIDE, may be used in the preparation of potential chiral solvating agents. These agents are crucial in the development of enantiomerically pure compounds, which are essential in the pharmaceutical industry due to their high specificity and reduced side effects.
Furthermore, (R)-(-)-N-(2,3-Epoxypropyl)phthalimide may also be used in the synthesis of 2-((5R)-2-oxo-5-oxazolidinyl)methyl)-1H-isoindole-1,3(2H)-dione, a compound with potential applications in the pharmaceutical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 181140-34-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,1,1,4 and 0 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 181140-34:
(8*1)+(7*8)+(6*1)+(5*1)+(4*4)+(3*0)+(2*3)+(1*4)=101
101 % 10 = 1
So 181140-34-1 is a valid CAS Registry Number.
InChI:InChI=1/C11H9NO3/c13-10-8-3-1-2-4-9(8)11(14)12(10)5-7-6-15-7/h1-4,7H,5-6H2/t7-/m1/s1
181140-34-1Relevant articles and documents
A novel homochiral metal-organic framework with an expanded open cage based on (: R)-3,3′-bis(6-carboxy-2-naphthyl)-2,2′-dihydroxy-1,1′-binaphthyl: synthesis, X-ray structure and efficient HPLC enantiomer separation
Tanaka, Koichi,Kawakita, Tomohiro,Morawiak, Maja,Urbanczyk-Lipkowska, Zofia
, p. 487 - 493 (2019/01/21)
A new homochiral metal-organic framework (MOF) with an expanded open cage based on the (R)-3,3′-bis(6-carboxy-2-naphthyl)-2,2′-dihydroxy-1,1′-binaphthyl ligand was synthesized and utilized as a novel chiral stationary phase for high-performance liquid chromatography. Twelve racemates including sec-alcohols, sulfoxides, epoxides, lactone, 1,3-dioxolan-2-one, and oxazolidinone were used as analytes for evaluating the separation properties of the chiral-MOF-packed column. Experimentally, the homochiral MOF offered good molecular recognition ability, which suggests good prospects for the application of chiral MOFs as stationary phases for enantioseparation.
A practical and enantiospecific synthesis of (-)-(R)- and (+)-(S)-piperidin-3-ols
Babu, Meruva Suresh,Raghunadh, Akula,Ramulu, Konda,Dahanukar, Vilas H.,Syam Kumar, Unniaran K.,Dubey, P. Kumar
, p. 1507 - 1515 (2015/02/19)
A highly enantiospecific, azide-free synthesis of (-)-(R)- and (+)-(S)-piperidin-3-ol in excellent yield was developed. The key step of the synthesis involves the enantiospecific ring openings of enantiomerically pure (R)- and (S)-2-(oxiran-2-ylmethyl)-1H-isoindole-1,3(2H)-diones with the diethyl malonate anion and subsequent decarboxylation.
1-Amido-3-(2-hydroxyphenoxy)-2-propanol derivatives and a process for preparing 2-amidomethyl-1,4-benzodioxane derivatives
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Page/Page column 5, (2008/06/13)
An 1-amido-3-(2-hydroxyphenoxy)-2-propanol derivative represented by the following formula (1), wherein cycle A may have further 1 to 4 substituents, and said substituent means a substituent selected from the group consisting of saturated or unsaturated C