181425-91-2Relevant articles and documents
Fluorescence quenching and size selective heterodimerization of a porphyrin adsorbed to gold and embedded in rigid membrane gaps
Fudickar, Werner,Zimmermann, J?rg,Ruhlmann, Laurent,Schneider, Johannes,R?der, Beate,Siggel, Ulrich,Fuhrhop, Jürgen-Hinrich
, p. 9539 - 9545 (1999)
Octaanionic meso-tetra(3,5-dicarboxylatophenyl) porphyrin 1 was adsorbed to gold electrodes at pH 12 and stayed there after repeated washing with 10- 2 M KOH. The fluorescence on sputtered gold surfaces amounted to 10% of the intensi
Viologen-based benzylic dendrimers: selective synthesis of 3,5-bis(hydroxymethyl)benzylbromide and conformational analysis of the corresponding viologen dendrimer subunit
Kathiresan, Murugavel,Walder, Lorenz,Ye, Fei,Reuter, Hans
supporting information; experimental part, p. 2188 - 2192 (2010/06/19)
Convergent and divergent strategies for the synthesis of viologen dendrimers with 1,3,5-tri-methylene-branching units are discussed. The title compound is easily transformed into 1-[3,5-bis(hydroxymethyl)benzyl]-4-(pyridin-4-yl)pyridinium hexafluorophosphate, which is used in sequential growth and activation steps as a CB2 compound in the cascade-type dendrimer synthesis (B = -OH, activation = -OH → Br). Analysis of the dendrimer structure reveals that three torsional angles, that is, τ1 between the two pyridinium units, τ2 between the methylene and pyridinium and τ3 between the methylene and phenyl, determine the conformational space of the dendrimers. We report here the crystal structure of 1-[3,5-bis(hydroxymethyl)benzyl]-4-(pyridin-4-yl)pyridinium as PF6- salt which represents the smallest subunit of the dendrimer that shows the same three torsional angles. The crystal structure together with the results from PM3 calculations opens an avenue to judge the structure of benzylic viologen-based dendrimers.
Potent and selective isophthalamide S2 hydroxyethylamine inhibitors of BACE1
Kortum, Steven W.,Benson, Timothy E.,Bienkowski, Michael J.,Emmons, Thomas L.,Prince, D. Bryan,Paddock, Donna J.,Tomasselli, Alfredo G.,Moon, Joseph B.,LaBorde, Alice,TenBrink, Ruth E.
, p. 3378 - 3383 (2008/02/09)
The design and synthesis of a novel series of potent BACE1 hydroxyethylamine inhibitors. These inhibitors feature hydrogen bonding substituents at the C-5 position of the isophthalamide ring with improved selectivity over cathepsin D.
