4105-92-4Relevant articles and documents
REACTION OF NUCLEOBASES WITH α-ACETYLENIC ESTERS, POTENTIALLY USEFULL FOR CHEMICAL MODIFICATION OF NUCLEIC ACIDS
Olomucki, M.,Gall, J. Y., Le,Colinart, S.,Durant, F.,Norberg, B.,Evrard, G.
, p. 3471 - 3474 (1984)
The NH2 group and the adjacent ring nitrogen of adenosine and cytidine react with α-acetylenic esters by addition across the triple bond and formation of a lactam with the ester group.
Understanding the Incorporation and Release of Salicylic Acid in Metal-Organic Frameworks for Topical Administration
Rojas, Sara,Horcajada, Patricia
, p. 1325 - 1331 (2021)
Although metal-organic frameworks (MOFs) have been widely demonstrated to be great candidates for drug delivery applications, they have been mainly proposed for the intravenous route. Here, eight highly porous benchmarked MOFs, with different topologies a
Cyclotrimerization of alkynes catalyzed by a self-supported cyclic tri-nuclear nickel(0) complex with α-diimine ligands
Shen, Lingyi,Zhao, Yanxia,Luo, Qiong,Li, Qian-Shu,Liu, Bin,Redshaw, Carl,Wu, Biao,Yang, Xiao-Juan
supporting information, p. 4643 - 4649 (2019/04/05)
A cyclic tri-nuclear α-diimine nickel(0) complex [{Ni(μ-LMe-2,4)}3] (2) was synthesized from a “pre-organized”, trimerized trigonal LNiBr2-type precursor [Ni3(μ2-Br)3(μ3-Br)2(LMe-2,4)3]·Br (1; LMe-2,4 = [(2,4-Me2C6H3)NC(Me)]2). In complex 2, the α-diimine ligands not only exhibit the normal N,N′-chelating mode, but they also act as bridges between the Ni atoms through an unusual π-coordination of a C═N bond to Ni. Complex 2 is able to catalyze the cyclotrimerization of alkynes to form substituted benzenes in good yield and regio-selectivity for the 1,3,5-isomers, which is found to vary with the nature of the alkyne employed. This complex represents a convenient self-supported nickel(0) catalyst with no need for additional ligands and reducing agent.
Silica Gel as a Promoter of Sequential Aza-Michael/Michael Reactions of Amines and Propiolic Esters: Solvent- and Metal-Free Synthesis of Polyfunctionalized Conjugated Dienes
Aleksi?, Jovana,Stojanovi?, Milovan,Baranac-Stojanovi?, Marija
, p. 1811 - 1835 (2018/07/29)
We present an efficient, simple, metal- and solvent-free silica-gel-promoted synthesis of functionalized conjugated dienes by sequential aza-Michael/Michael reactions by starting from commercially available primary amines and propiolic esters. The scope a