18209-14-8 Usage
Description
N-methylmitomycin A is a derivative of mitomycin, a class of antibiotics with potent antineoplastic properties. It is characterized by the presence of a methyl group attached to the nitrogen atom in the mitosene ring, which may confer unique chemical and biological properties compared to its parent compound.
Uses
Used in Pharmaceutical Industry:
N-methylmitomycin A is used as an intermediate in the synthesis of mitomycin B (M371895), an antitumor antibiotic with significant antineoplastic activity. This makes it a valuable component in the development of cancer therapeutics, potentially offering new avenues for the treatment of various malignancies.
As an antineoplastic agent, N-methylmitomycin A may contribute to the inhibition of tumor growth and the disruption of cancer cell metabolism, thereby playing a crucial role in cancer treatment and management. Its specific application in the pharmaceutical industry could involve its use in the formulation of drugs targeting a range of cancer types, leveraging its unique structural features to enhance therapeutic efficacy and selectivity.
Check Digit Verification of cas no
The CAS Registry Mumber 18209-14-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,2,0 and 9 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 18209-14:
(7*1)+(6*8)+(5*2)+(4*0)+(3*9)+(2*1)+(1*4)=98
98 % 10 = 8
So 18209-14-8 is a valid CAS Registry Number.
InChI:InChI=1/C17H21N3O6/c1-7-12(21)11-10(13(22)14(7)24-3)8(6-26-16(18)23)17(25-4)15-9(19(15)2)5-20(11)17/h8-9,15H,5-6H2,1-4H3,(H2,18,23)/t8-,9+,15+,17-,19?/m1/s1
18209-14-8Relevant articles and documents
Mass spectrometric studies of antibiotics. I. Mass spectra of mitomycin antibiotics.
Van Lear
, p. 2587 - 2597 (1970)
-
STEROIDAL ANTI-HORMONE HYBRIDS
-
Page/Page column 39, (2010/08/08)
Disclosed are novel compounds and compositions for inhibition of androgen and estrogen receptor signaling, methods for inhibiting androgen signaling, methods for inhibiting estrogen signaling, methods for inhibiting the interaction between a co-regulatory protein and an androgen or estrogen receptor, and methods for treating cancer.
On the Remarkable Stability of Derivatives of Leucomitomycin F. Novel Mitomycin Analogues
Egbertson, Melissa,Danishefsky, Samuel J.,Schulte, Gayle
, p. 4424 - 4426 (2007/10/02)
The leuco form of mitomycin F reacts with silica gel in the presence of oxygen to afford 9-epimitomycin B.A notable stability is manifested by hydroquinoid forms (leucomitomycin) bearing a 9,10-exocyclic methylene group.