182305-80-2

Basic information

• Product Name: {(S)-1-[(S)-6,7-Dimethoxy-1-(4-methoxy-benzyl)-3,4-dihydro-1H-isoquinolin-2-yl]-pyrrolidin-2-yl}-methanol
• Synonyms: {(S)-1-[(S)-6,7-Dimethoxy-1-(4-methoxy-benzyl)-3,4-dihydro-1H-isoquinolin-2-yl]-pyrrolidin-2-yl}-methanol
• CAS NO: 182305-80-2
• Molecular Weight: 412.529
• Mol File: 182305-80-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {(S)-1-[(S)-6,7-Dimethoxy-1-(4-methoxy-benzyl)-3,4-dihydro-1H-isoquinolin-2-yl]-pyrrolidin-2-yl}-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: {(S)-1-[(S)-6,7-Dimethoxy-1-(4-methoxy-benzyl)-3,4-dihydro-1H-isoquinolin-2-yl]-pyrrolidin-2-yl}-methanol(182305-80-2)
• EPA Substance Registry System: {(S)-1-[(S)-6,7-Dimethoxy-1-(4-methoxy-benzyl)-3,4-dihydro-1H-isoquinolin-2-yl]-pyrrolidin-2-yl}-methanol(182305-80-2)

Safety Data

• Hazardous Substances Data: 182305-80-2(Hazardous Substances Data)

Upstream product

• 123190-12-5 2-(2-bromoethyl)-4,5-(dimethoxy)benzaldehyde 
• 127221-89-0 (S)-(-)-1-amino-2-(hydroxymethyl)pyrrolidine 
• 38769-92-5 4-methoxybenzylmagnesium chloride 
• 182305-82-4 (9R,13S)-2,3-Dimethoxy-6,9,13,15,16,17-hexahydro-7H,12H-11-oxa-8,14-diaza-cyclopenta[a]phenanthrene 

Downstream Products

• 3423-02-7 (R)-(-)-O-methylarmepavine 
• 3611-33-4 O,O-Dimethylcoclaurine 

Relevant articles and documents

Lewis acid-mediated nucleophilic alkylations on chiral [6,3a,4]oxadiazaindano[5,4-a]isoquinolines. Asymmetric synthesis of 1-alkyl substituted tetrahydroisoquinolines

Lewis acid-mediated nucleophilic alkylation of the chiral [6,3a,4]oxadiazaindano[5,4-a]isoquinoline derivatives with various organometallic reagents leads to highly enantioselective synthesis of 1-alkyl substituted tetrahydroisoquinolines. This methodology was applied to the asymmetric synthesis of (-)-salsolidine and (+)-O-methylarmepavine.