182345-24-0Relevant articles and documents
Convenient preparation of N-substituted indoles by modified Leimgruber-Batcho indole synthesis
Coe, Jotham W.,Vetelino, Michael G.,Bradlee, Michael J.
, p. 6045 - 6048 (2007/10/03)
A modified reductive alkylation of pre-indole 3, prepared from readily available Leimgruber-Batcho indole synthesis derived intermediates, followed by acidic methanolysis generates 6-carbomethoxy-N-substituted indoles. The three step preparation of pre-indole 3 from substituted 2-nitrotoluene 1 in 66% yield and conversion to a variety of N-substituted indoles is presented.