18269-64-2

Basic information

• Product Name: TRIMETHYLSILYL CROTONATE
• Synonyms: TRIMETHYLSILYL CROTONATE;CH3CHCHCOOSi(CH3)3;Trimethylsilyl-2-Butenoic Acid
• CAS NO: 18269-64-2
• Molecular Formula: C₇H₁₄O₂Si
• Molecular Weight: 158.27
• Product Categories: Building Blocks;C6 to C7;Carbonyl Compounds;Chemical Synthesis;Esters;Organic Building Blocks
• Mol File: 18269-64-2.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 49-50 °C10 mm Hg(lit.)
• Flash Point: 104 °F
• Appearance: clear colourless liquid
• Density: 0.897 g/mL at 25 °C(lit.)
• Vapor Pressure: 6.61mmHg at 25°C
• Refractive Index: n20/D 1.4252(lit.)
• Storage Temp.: 0-6°C
• CAS DataBase Reference: TRIMETHYLSILYL CROTONATE(CAS DataBase Reference)
• NIST Chemistry Reference: TRIMETHYLSILYL CROTONATE(18269-64-2)
• EPA Substance Registry System: TRIMETHYLSILYL CROTONATE(18269-64-2)

Safety Data

• Hazard Codes: F,Xi
• Statements: 11-36/37/38
• Safety Statements: 16-26-36
• RIDADR: UN 3272 3/PG 3
• WGK Germany: 3
• TSCA: No
• Hazardous Substances Data: 18269-64-2(Hazardous Substances Data)

Usage

Chemical Properties

clear colourless liquid

InChI:InChI=1/C7H14O2Si/c1-5-6-7(8)9-10(2,3)4/h5-6H,1-4H3/b6-5+

Upstream product

• 3724-65-0 2-butenoic acid 
• 75-77-4 chloro-trimethyl-silane 
• 43112-38-5 3-(trimethylsilyl)-2-oxazolidinone 
• 4648-54-8 trimethylsilylazide 
• 1825-62-3 ethyl trimethylsilyl ether 
• 623-68-7 crotonic anhydride 
• 107-93-7 (E)-but-2-enoic acid 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 

Downstream Products

• 87121-06-0 1,1-bis(trimethylsilyloxy)-buta-1,3-diene 
• 6624-56-2 3-phenylpropyl (E)-2-butenoate 
• 150272-55-2 3-phenylpropyl 3-butenoate 
• 55600-70-9 crotonyl bromide 
• 87121-18-4 3-(2,2-Bis-trimethylsilanyloxy-vinyl)-2,2-diphenyl-cyclobutanone 
• 1357518-68-3 (E)-PhSiF₂OC(O)CH=CHCH₃ 
• 1344680-48-3 (E)-PhSiFClOC(O)CH=CHCH₃ 
• 1357518-87-6 (E)-PhSiF[OC(O)CH=CHCH₃]2 
• 75-77-4 chloro-trimethyl-silane 
• 1013916-37-4 2-chloro-5-methyl-8-cyclopentylpyridin[2,3-d]pyrimidin-8-hydro-7-one 

Relevant articles and documents

Preparation method of silicon-based ester compound, silicon-based ester compound, electrolyte containing silicon-based ester compound and secondary battery

The invention relates to a preparation method of a silicon-based ester compound, the silicon-based ester compound, an electrolyte containing the silicon-based ester compound and a secondary battery. The preparation method of the silicon-based ester compound comprises the following steps: adding organic alkali and organic acid into a solvent and carrying out reacting to obtain an intermediate, andthen, adding halogenated silane to react with the intermediate to obtain the silicon-based ester compound, wherein the intermediate is ionic liquid. The preparation method provided by the invention can relieve the problems of long reaction time, difficult treatment of byproducts, complex operation caused by step-by-step reaction, high cost, difficult industrial scale-up production and the like inthe existing synthesis method.

A PROCESS FOR THE PREPARATION OF PALBOCICLIB

The present invention relates to a process for the preparation of palbociclib utilizing a silyl-protected crotonic acid derivative to produce a silyl-protected 5-(1-methyl-3 carboxy-prop-1-en-1-yl)-2-chloro-piperazine followed by intramolecular cyclization of the compound the piperazine intermediate to produce 2-chloro-8-cyclopentyl-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one which is then converted to palbociclib.

CYANOQUINOLINE DERIVATIVES

Disclosed is a compound of formula I, a stereoisomer thereof, a cis-trans-isomer thereof, a tautomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof, a solvate thereof or a prodrug thereof, wherein R1, R2