182919-58-0

Basic information

• Product Name: 1-BENZYLPIPERIDINE-3-CARBOHYDRAZIDE
• Synonyms: 1-BENZYLPIPERIDINE-3-CARBOHYDRAZIDE;1-(Phenylmethyl)-3-piperidinecarboxylic hydrazide
• CAS NO: 182919-58-0
• Molecular Formula: C₁₃H₁₉N₃O
• Molecular Weight: 233.31
• Mol File: 182919-58-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 415.3±34.0 °C(Predicted)
• Appearance: /
• Density: 1.149±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 13.23±0.20(Predicted)
• CAS DataBase Reference: 1-BENZYLPIPERIDINE-3-CARBOHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZYLPIPERIDINE-3-CARBOHYDRAZIDE(182919-58-0)
• EPA Substance Registry System: 1-BENZYLPIPERIDINE-3-CARBOHYDRAZIDE(182919-58-0)

Safety Data

• Hazardous Substances Data: 182919-58-0(Hazardous Substances Data)

Usage

General Description

1-Benzylpiperidine-3-carbohydrazide, also known as BPCH, is a chemical compound with the molecular formula C16H22N4O. It is a hydrazide derivative of piperidine and is commonly used as a building block in the synthesis of various pharmaceutical compounds. BPCH has been studied for its potential as an anti-tuberculosis agent and for its inhibitory effects on the growth of various cancer cell lines. It has also been investigated for its role in the treatment of neurodegenerative diseases such as Alzheimer's and Parkinson's. Additionally, 1-Benzylpiperidine-3-carbohydrazide has shown promise as a corrosion inhibitor in industrial applications.

Upstream product

• 72551-53-2 ethyl 1-benzylpiperidine-3-carboxylate 
• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 

Downstream Products

• 60407-35-4 1-phenylmethyl-3-aminopiperidine 
• 919100-20-2 (3RS)-1-(phenylmethyl)-3-piperidinecarboxylic acid 2-[(methylamino)thioxomethyl]hydrazide 

Relevant articles and documents

Synthesis, bioactivity and molecular modeling studies on potential anti-Alzheimer piperidinehydrazide-hydrazones

A group of N-benzylpiperidine-3/4-carbohydrazide-hydrazones were designed, synthesized and evaluated for acetylcholinesterase (AChE), butyrylcholinesterase (BuChE)activities, Aβ42 self-aggregation inhibitory potentials, and antioxidant capacities, in vitro. All of the compounds displayed eeAChE and huAChE inhibitory activity in a range of IC50 = 5.68–11.35 μM and IC50 = 8.80–74.40 μM, respectively and most of the compounds exhibited good to moderate inhibitory activity on BuChE enzyme. Kinetic analysis and molecular modeling studies were also performed for the most potent compounds (1g and 1j). Not only the molecular modeling studies but also the kinetic analysis suggested that these compounds might be able to interact with the catalytic active site (CAS)and the peripheral anionic site (PAS)of the enzymes. In the light of the results, compound 1g and compound 1j may be suggested as lead compounds for multifunctional therapy of AD.

Novel 1,5-diaryl pyrazole-3-carboxamides as selective COX-2/sEH inhibitors with analgesic, anti-inflammatory, and lower cardiotoxicity effects

COX-2 selective drugs have been withdrawn from the market due to cardiovascular side effects, just a few years after their discovery. As a result, a new series of 1,5-diaryl pyrazole carboxamides 19–31 was synthesized as selective COX-2/sEH inhibitors wit

A convenient route to 1-benzyl 3-aminopyrrolidine and 3-aminopiperidine

1-Benzyl 3-aminopyrrolidine 1 and 1-benzyl 3-aminopiperidine 2 were prepared rapidly mainly in aqueous conditions in 55 and 75% yields, respectively, on a multi-gram scale starting from inexpensive and commercially available starting materials. The key step involved the Curtius rearrangement mediated by sodium nitrite and trifluoroacetic acid of the appropriate acylhydrazides. All the reactions (except LAH reductions) were performed in water.