72551-53-2Relevant articles and documents
Novel 1,5-diaryl pyrazole-3-carboxamides as selective COX-2/sEH inhibitors with analgesic, anti-inflammatory, and lower cardiotoxicity effects
Hendawy,Gomaa, Hesham A.M.,Alzarea, Sami I.,Alshammari, Mutariah S.,Mohamed, Fatma A.M.,Mostafa, Yaser A.,Abdelazeem, Ahmed H.,Abdelrahman, Mostafa H.,Trembleau, Laurent,Youssif, Bahaa G.M.
, (2021/09/01)
COX-2 selective drugs have been withdrawn from the market due to cardiovascular side effects, just a few years after their discovery. As a result, a new series of 1,5-diaryl pyrazole carboxamides 19–31 was synthesized as selective COX-2/sEH inhibitors wit
Synthesis, biological evaluation, docking study and ulcerogenicity profiling of some novel quinoline-2-carboxamides as dual COXs/LOX inhibitors endowed with anti-inflammatory activity
Abdelrahman, Mostafa H.,Youssif, Bahaa G.M.,abdelgawad, Mohamed A.,Abdelazeem, Ahmed H.,Ibrahim, Hussein M.,Moustafa, Abd El Ghany A.,Treamblu, Laurent,Bukhari, Syed Nasir Abbas
, p. 972 - 985 (2017/02/13)
A series of novel quinoline-2-carboxamides 15–28 was synthesized and evaluated in?vitro as dual COXs/LOX inhibitors. Compounds 19 and 27 exhibited the highest potency and selectivity for COX-2 inhibitory activity (IC50?=?1.21 and 1.13?μM, respe
A simple iridicycle catalyst for efficient transfer hydrogenation of n-heterocycles in water
Talwar, Dinesh,Li, Ho Yin,Durham, Emma,Xiao, Jianliang
supporting information, p. 5370 - 5379 (2015/03/30)
A cyclometalated iridium complex is shown to catalyse the transfer hydrogenation of various nitrogen heterocycles, including but not limited to quinolines, isoquinolines, indoles and pyridinium salts, in an aqueous solution of HCO2H/HCO2Na under mild conditions. The catalyst shows excellent functional-group compatibility and high turnover number (up to 7500), with catalyst loadings as low as 0.01 mol % being feasible. Mechanistic investigation of the quinoline reduction suggests that the transfer hydrogenation proceeds via both 1,2- and 1,4-addition pathways, with the catalytic turnover being limited by the step of hydride transfer. An easily accessible iridicycle catalyst effects the transfer hydrogenation of a wide variety of N-heterocycles in water, including quinolines, isoquinolines, indoles, quinoxalines, and pyridines. The catalyst shows excellent functional-group compatibility and high turnover number (up to 7500), even with low catalyst loadings.
