183133-94-0 Usage
Description
(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one is a complex organic compound with a unique molecular structure. It is characterized by its stereochemistry, which is defined by the R and S configurations at various carbon positions. (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one is likely to have specific applications in the pharmaceutical or chemical industries due to its intricate structure and functional groups.
Uses
1. Used in Pharmaceutical Industry:
(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one is used as an intermediate for the synthesis of various pharmaceutical compounds. Its unique structure and functional groups make it a valuable building block for the development of new drugs with potential therapeutic applications.
2. Used in Chemical Research:
(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one is also used in chemical research as a model for studying the synthesis and reactivity of complex organic molecules. Its stereochemistry and functional groups can provide insights into the mechanisms of various chemical reactions and help in the development of new synthetic methods.
3. Used in Material Science:
The compound may have potential applications in the field of material science, where its unique structure and properties could be exploited to develop new materials with specific characteristics, such as improved stability or reactivity.
Synthesis
Solvent is methylene dichloride, and alkali is the two dimethylamino naphthalene of 1,8-, and the mol ratio of 10-deacetylate Bakating III and trimethylammonium oxygen Tetrafluoroboric acid is 1:35; The mol ratio of 10-deacetylate Bakating III and alkali is 1:45;By 10-Dab (10g, 18.4mmol) be dissolved in methylene dichloride (200ml), add 1, the two dimethylamino naphthalene (177.2g of 8-, 828mmol), stirring at room temperature half an hour, add trimethylammonium oxygen Tetrafluoroboric acid (95.2g, 643.4mmol) again, stirring at room temperature 20h, suction filtration reaction solution, filter cake methylene dichloride washes 3 times, collects filtrate, and after concentrated, column chromatography (chloroform: methyl alcohol=100:3) obtains 7,10-dimethoxy-10Dab III 4.6g, yield 43.7%.
Check Digit Verification of cas no
The CAS Registry Mumber 183133-94-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,3,1,3 and 3 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 183133-94:
(8*1)+(7*8)+(6*3)+(5*1)+(4*3)+(3*3)+(2*9)+(1*4)=130
130 % 10 = 0
So 183133-94-0 is a valid CAS Registry Number.
InChI:InChI=1S/C31H40O10/c1-16-19(33)14-31(36)26(40-27(35)18-11-9-8-10-12-18)24-29(5,25(34)23(38-7)22(16)28(31,3)4)20(37-6)13-21-30(24,15-39-21)41-17(2)32/h8-12,19-21,23-24,26,33,36H,13-15H2,1-7H3/t19-,20-,21+,23+,24?,26-,29+,30-,31+/m0/s1
183133-94-0Relevant articles and documents
Isolation, identification and characterization of potential impurities in cabazitaxel and their formation
Wang, Yongyi,Feng, Feng,Chen, Lei,Zhao, Hongtao,Tian, Lianzhong
, p. 783 - 788 (2014)
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Cabazitaxel precursor derivative as well as synthesis method and application thereof
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Paragraph 0079, (2020/02/20)
The invention discloses a preparation method of 7,10-dimethoxy-10-DAB (deacetyl baccatin) and a cabazitaxel precursor derivative as well as a synthesis method and application of the cabazitaxel precursor derivative. The synthesis method disclosed by the invention has the advantages of being easy in raw material obtaining, less in step, simple and convenient in purification and high in yield, and has the prospect of industrial production. The cabazitaxel precursor derivative synthetisedby the synthesis methoddisclosed by the invention has excellent antitumor activity and great application prospects.
Preparation method of 7beta,10beta-dimethoxy-10-deacetylbaccatin III
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Paragraph 0036; 0046; 0047, (2017/08/29)
The invention relates to a preparation method of 7beta,10beta-dimethoxy-10-deacetylbaccatin III. Particularly, the method provided by the invention takes acetylbaccatin as a raw material and comprises a series of the following steps: protecting through silicon protecting groups at a 7 site and a 13 site; selectively removing the silicon protecting group at the 7 site; directly alkylating at the 7 site and a 10 site; and finally, removing the silicon protecting group at the 13 site to prepare a taxane compound, namely the 7beta,10beta-dimethoxy-10-deacetylbaccatin III shown as a formula V. (The formula V is shown in the description.).