7,10-Dimethoxy-10-DAB III CAS No.:183133-94-0 Name: 7,10-Dimethoxy-10-DAB III Synonyms: (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4
Cas:183133-94-0
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inquiryDayangChem exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product s
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inquiryProduct Name: (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one Syn
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inquiryOur advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be sent
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:183133-94-0
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inquiryChemical Name: 7,10-Dimethoxy-10-DAB III Cas No.: 183133-94-0 Molecular Structure: Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package:25kg/drum Application:APIs Trans
Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryHanways Chempharm Co., Limited, the former is Hubei Hanways Pharchem CO.,Limited, set up in 2009 in Wuhan, China. We specialize in sourcing and supplying APIs, pharmaceutical intermediates, and fine chemicals for worldwide markets. The founder has d
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inquiry7,10-Dimethoxy-10-DAB III Chemical Properties Boiling point 675.8±55.0 °C(Predicted) density 1.31 storage temp. Sealed in dry,Room Temperature pka 12.82±0.70(Predicted) Safety Information HS Code 29329990 7,10-Di
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inquiry7,10-Dimethoxy-10-DAB III CAS:183133-94-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organi
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryPRODUCT DETAILS
Cas:183133-94-0
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:183133-94-0
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inquiry7β,10β-diMethoxy-10-DAB-IIpuAppearance:colorless liquid Storage:2-8 ℃ or Others Package:according to customers' requirements Application:Pharmaceutical intermediates Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or CNF
Superior quality, moderate price & quick delivery. Appearance:white or off-white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Used a
Lyander’s R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. Lyander can provide different quantities of cu
Cas:183133-94-0
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inquiryProduct name: 7,10-Dimethoxy-10DABIII CAS No.:183133-94-0 Molecule Formula:C31H40O10 Molecule Weight:572.64 Purity: 98.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTIN
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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inquiryProduct Name: (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4,6-dim…Appearance:Solid powder Storage:Sealed,light and oxygen resistant Package:aluminum foil bag,carton
Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an
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inquiryZhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed
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inquiryWe have most reliable quality, competitive prices and full documents for this APIs 1. GMP WORKSHOP 2. DMF Application:Pharmaceutical intermediate
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inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
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inquirySAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in
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inquiry10-deacetylbaccatin III
carbonic acid dimethyl ester
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene
Conditions | Yield |
---|---|
With dmap; caesium bromide; sodium hydride In tetrahydrofuran; N,N-dimethyl-formamide at -30℃; for 3h; Temperature; Reagent/catalyst; | 89.6% |
10-deacetylbaccatin III
methyl trifluoromethanesulfonate
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene
Conditions | Yield |
---|---|
Stage #1: 10-deacetylbaccatin III With lithium hexamethyldisilazane In tetrahydrofuran at -72℃; for 0.666667h; Inert atmosphere; Stage #2: methyl trifluoromethanesulfonate In tetrahydrofuran at -72℃; for 4.08333h; Inert atmosphere; | 87% |
Stage #1: 10-deacetylbaccatin III With n-butyllithium In tetrahydrofuran at -78 - -35℃; for 1h; Inert atmosphere; Stage #2: methyl trifluoromethanesulfonate In tetrahydrofuran for 1h; Temperature; | 55% |
7,10-methylthiomethyl-10-deacetylbaccatin III
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene
Conditions | Yield |
---|---|
With water; Raney nickel In methanol at 23℃; | 61% |
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-10β-methoxy-9-oxo-1β,13α,7β-trihydroxy-11-taxene
methyl iodide
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene
Conditions | Yield |
---|---|
With potassium hydride In tetrahydrofuran at 0 - 20℃; | 61% |
With sodium hydride In N,N-dimethyl acetamide at -15 - -5℃; for 1h; Concentration; | 58.8% |
With sodium hydride In N,N-dimethyl acetamide at -15 - -10℃; Time; | 58.8% |
Stage #1: 4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-10β-methoxy-9-oxo-1β,13α,7β-trihydroxy-11-taxene; methyl iodide In N,N-dimethyl-formamide at 20 - 30℃; for 0.5h; Stage #2: With sodium hydride In N,N-dimethyl-formamide; paraffin oil at 0 - 5℃; Reagent/catalyst; Solvent; Temperature; |
13-acetyl-7,10-dimethoxy-10-DAB
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene
Conditions | Yield |
---|---|
With hydrazine hydrate In N,N-dimethyl-formamide at 23℃; for 18h; Inert atmosphere; | 53% |
10-deacetylbaccatin III
methyl iodide
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene
Conditions | Yield |
---|---|
Stage #1: 10-deacetylbaccatin III With n-butyllithium In tetrahydrofuran at -75 - -35℃; for 1h; Inert atmosphere; Stage #2: methyl iodide for 1h; | 52% |
With potassium hydride In tetrahydrofuran at -20 - 20℃; for 8h; | |
With sodium hydride In tetrahydrofuran; mineral oil at 0 - 25℃; for 7.5h; Reagent/catalyst; Temperature; Solvent; Time; | |
With caesium bromide; sodium hydride In tetrahydrofuran; N,N-dimethyl-formamide at -20 - 20℃; for 2.33333h; Inert atmosphere; | |
With sodium hydride In N,N-dimethyl-formamide for 1.5h; Solvent; Temperature; | 10 g |
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,10β-dihydroxy-9-oxo-7β,13α-di(triethylsilyloxy)-11-taxene
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium hydride / tetrahydrofuran / -5 - 0 °C 2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 5 °C / Inert atmosphere 3: sodium hydride / tetrahydrofuran / -5 - 0 °C 4: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 5 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 4 steps 1: sodium hydride / tetrahydrofuran / -5 - 0 °C 2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 5 °C / Inert atmosphere 3: sodium hydride / -5 - 0 °C 4: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 5 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: triethylamine tris(hydrogen fluoride) / dichloromethane / 16 h / 20 °C 2: potassium tert-butylate / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere 3: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C View Scheme |
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β-hydroxy-9-oxo-10β-methoxy-7β,13α-di(triethylsilyloxy)-11-taxene
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 5 °C / Inert atmosphere 2: sodium hydride / tetrahydrofuran / -5 - 0 °C 3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 5 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 5 °C / Inert atmosphere 2: sodium hydride / -5 - 0 °C 3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 5 °C / Inert atmosphere View Scheme |
7,10-di-O-1,3-dithian-2-yl-10-DAB
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene
Conditions | Yield |
---|---|
With hydrogen In N,N-dimethyl-formamide at 50℃; under 8274.59 Torr; for 23h; |
10-O-methyl-7-O-1,3-benzodithiolan-2-yl-10-DAB
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene
Conditions | Yield |
---|---|
With hydrogen In N,N-dimethyl-formamide at 20℃; under 2584.17 Torr; for 15h; |
C57H67NO15S4
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: methanol; sodium tetrahydroborate / tetrahydrofuran / 3 h / 20 °C 2: hydrogen / N,N-dimethyl-formamide / 23 h / 50 °C / 8274.59 Torr View Scheme |
C37H48O10S4
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene
Conditions | Yield |
---|---|
With hydrogen In N,N-dimethyl-formamide at 20℃; under 2584.17 Torr; for 15h; |
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-10β-methoxy-9-oxo-1β,13α,7β-trihydroxy-11-taxene
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: pyridine / dichloromethane / 20 °C 2: hydrogen / N,N-dimethyl-formamide / 15 h / 20 °C / 2584.17 Torr View Scheme |
10-deacetylbaccatin III
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene
Conditions | Yield |
---|---|
With caesium bromide; sodium hydride In tetrahydrofuran; N,N-dimethyl-formamide at -20 - 20℃; for 2.33333h; Inert atmosphere; |
10-deacetylbaccatin III
methyl trifluoromethanesulphonate
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene
Conditions | Yield |
---|---|
With caesium bromide; sodium hydride In tetrahydrofuran; N,N-dimethyl-formamide at -20 - 20℃; for 2.33333h; Inert atmosphere; |
carbazitaxel
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene
Conditions | Yield |
---|---|
With sodium hydroxide In water; acetonitrile at 20℃; for 0.5h; Further stages; |
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-10β-methoxy-9-oxo-1β,13α,7β-trihydroxy-11-taxene
dimethyl sulfate
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide; mineral oil at -30℃; for 1h; |
methylmagnesium bromide
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; for 3h; Inert atmosphere; |
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene
(2R,4S,5R)-(2R,4S,5R)-3-tert-butoxycarbonyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β-hydroxy-7β,10β-dimethoxy-9-oxo-11-taxene-13α-yl (2R,4S,5R)-3-tert-butoxycarbonyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylate
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃; for 2h; | 91% |
With dmap; dicyclohexyl-carbodiimide In tetrahydrofuran | |
With dmap; dicyclohexyl-carbodiimide In toluene at 20 - 30℃; | |
With dmap; dicyclohexyl-carbodiimide In ethyl acetate at 20℃; for 3h; |
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene
Conditions | Yield |
---|---|
Stage #1: 4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene; (2R,4S,5S)-3-tert-butoxycarbonyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid With dmap In tetrahydrofuran at 20 - 30℃; for 0.5h; Stage #2: With dicyclohexyl-carbodiimide In tetrahydrofuran Reagent/catalyst; Concentration; Temperature; Solvent; | 82.5% |
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene
(2S,4S,5R)-3-tert-butoxycarbonyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid
Conditions | Yield |
---|---|
With dmap; diisopropyl-carbodiimide In tetrahydrofuran at 20 - 30℃; Reagent/catalyst; Solvent; Time; Temperature; | 82.5% |
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene
tert-butyl (3R,4S)-2-oxo-4-phenyl-3-(triethylsilyloxy)azetidine-1-carboxylate
1-hydroxy-7β,10β-di-methoxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-trethylsilyloxy-3-phenylpropanoate}
Conditions | Yield |
---|---|
With lithium hexamethyldisilazane In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 1.58333h; Inert atmosphere; | 80% |
With iron(III) chloride; sodium hydride In tetrahydrofuran; mineral oil at -15 - 20℃; for 2.5h; Product distribution / selectivity; Inert atmosphere; | 45% |
With sodium hydride; lithium bromide In tetrahydrofuran at -15 - 20℃; for 2h; Inert atmosphere; |
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene
Conditions | Yield |
---|---|
Stage #1: 4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene; (4S,5R)-3-(2-furanylcarbonyl)-2-(4-methoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid With dmap; dicyclohexyl-carbodiimide In toluene at 70℃; for 1h; Stage #2: With hydrogenchloride In ethanol at 20℃; for 16h; | 56% |
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene
Conditions | Yield |
---|---|
Stage #1: 4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene; (4S,5R)-3-(2-thienylcarbonyl)-2-(4-methoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid With dmap; dicyclohexyl-carbodiimide In toluene at 70℃; for 1h; Stage #2: With hydrogenchloride In ethanol at 20℃; for 16h; | 56% |
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene
Conditions | Yield |
---|---|
Stage #1: 4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene; (4S,5R)-3-(4-dimethylaminobenzoyl)-2-(4-methoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid With dmap; dicyclohexyl-carbodiimide In toluene at 70℃; for 1h; Stage #2: With hydrogenchloride In ethanol at 20℃; for 16h; | 56% |
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene
C24H26N2O7
(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-2-((((benzyloxy)carbonyl)glycyl)oxy)-3-((tert-butoxycarbonyl)amino)-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In ethyl acetate at 20℃; Molecular sieve; Inert atmosphere; |
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene
tert-butyl (3R,4S)-2-oxo-4-phenyl-3-(triethylsilyloxy)azetidine-1-carboxylate
carbazitaxel
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.58 h / 20 °C / Inert atmosphere 2: toluene-4-sulfonic acid / tetrahydrofuran; methanol / 1 h / 0 - 5 °C View Scheme |
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene
carbazitaxel
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.08 h / 20 °C / Inert atmosphere 2: toluene-4-sulfonic acid / butan-1-ol / 1 h / 50 °C View Scheme |
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene
Conditions | Yield |
---|---|
With lithium hexamethyldisilazane In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 1.08333h; Product distribution / selectivity; Inert atmosphere; |
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene
carbazitaxel
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: dmap; dicyclohexyl-carbodiimide / tetrahydrofuran 2: water; hydrogenchloride / methanol / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: dmap / tetrahydrofuran / 0.5 h / 20 - 30 °C 2: hydrogenchloride / ethyl acetate / 0 °C View Scheme | |
Multi-step reaction with 2 steps 1: dmap; dicyclohexyl-carbodiimide / tetrahydrofuran / 2 h / 20 °C 2: hydrogenchloride / methanol; water; 2-methyltetrahydrofuran / 0.5 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 5 h / 60 °C 2: formic acid / 4 h / 20 °C 3: methanol / 14 h / 25 - 35 °C View Scheme | |
Multi-step reaction with 2 steps 1: dicyclohexyl-carbodiimide; dmap / ethyl acetate / 3 h / 20 °C 2: hydrogenchloride / dichloromethane; methanol; water / 1 h / 0 °C View Scheme |
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene
(αR, βS)-α-hydroxy-β-[[(1,1-dimethylethoxy)carbonyl]amino]benzene-propanoic acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,1112,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester isopropanol solvate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: dmap / tetrahydrofuran / 0.5 h / 20 - 30 °C 2.1: hydrogenchloride / ethyl acetate / 0 °C 3.1: hydrogenchloride / methanol; water / 20 - 30 °C 3.2: 3.5 h / 0 - 30 °C View Scheme |
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