We are both manufacture and trader , have very good quality and competitive price, meanwhile , we have exported to other market 100kg every month. Appearance:white powder Storage:Nomal Package:25kg/drum Application:intermediates Transportation:Nor
Cas:32981-86-5
Min.Order:1 Kilogram
FOB Price: $280.0
Type:Manufacturers
inquirywe are reliable supplier for APIs and intermediates for international market. we supply good quality with competitive price. Appearance:white powder Storage:normal temperature Package:alum.bag then in carton Application:Pharmaceutical interme
Cas:32981-86-5
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryChengdu Biopurify Phytochemicals Ltd. is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medic
Cas:32981-86-5
Min.Order:1 Milligram
Negotiable
Type:Lab/Research institutions
inquiryDayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:32981-86-5
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:32981-86-5
Min.Order:1 Metric Ton
Negotiable
Type:Manufacturers
inquirySuperiority kono chem is a leading manufacturer and supplier of chemicals in China. We develop ,produce and distribute high quality pharmaceuticals, intermediates, special chemicals and other fine chemicals. We could give you: 1.Best
Cas:32981-86-5
Min.Order:1 Kilogram
FOB Price: $1.0 / 100.0
Type:Other
inquiryHebei yanxi chemical co., LTD is a professional research, development and production 2-phenylacetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low carbon environ
Cas:32981-86-5
Min.Order:10 Gram
FOB Price: $3.5 / 10.0
Type:Manufacturers
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:32981-86-5
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:32981-86-5
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:32981-86-5
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryProduct Name: 10-Deacetylbaccatin III Synonyms: 10-Deacetyl Baccatin lll;Docetaxel IMpurity E (10-Deacetyl Baccatin III);ó;7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one, 12b-(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,
Cas:32981-86-5
Min.Order:1 Gram
FOB Price: $8900.0
Type:Lab/Research institutions
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:32981-86-5
Min.Order:1 Kilogram
FOB Price: $1.0 / 10.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:32981-86-5
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryWe are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED
Cas:32981-86-5
Min.Order:1 Gram
FOB Price: $2.0
Type:Lab/Research institutions
inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our
Cas:32981-86-5
Min.Order:10 Gram
Negotiable
Type:Other
inquiryProName: 10-Deacetylbaccatin Ⅲ. CasNo: 32981-86-5 Molecular Formula: C29H36O10 Appearance: white or off-white powder Application: It is an important raw material and intermediate used in organic synthesis, pharmaceuticals,agrochemical and d
Cas:32981-86-5
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:32981-86-5
Min.Order:10 Gram
FOB Price: $1.32
Type:Trading Company
inquiryProduct Name: 10-Deacetylbaccatin III Synonyms: 10-Deacetyl Baccatin lll;Deacetylbaccatin III;10-deacetylbaccatin11;10-deacetylbaccatiniii(extaxusbaccata);10-DAB;10-DEACETYLBACCATIN III FROMTAXUS BACCAT A;10-Dab98.5%;10-Deacetylbaccatine(III) C
Cas:32981-86-5
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryAbout Product Details Items Specifications Test Results Appearance White to white crystalline powde
Cas:32981-86-5
Min.Order:1 Kilogram
FOB Price: $1.0 / 2.0
Type:Lab/Research institutions
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:32981-86-5
Min.Order:1 Kilogram
FOB Price: $160.0 / 200.0
Type:Trading Company
inquiryBeluga chemical professional supply High quality10-Deacetylbaccatin IIICAS 32981-86-5 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made in
Cas:32981-86-5
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:32981-86-5
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:32981-86-5
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Cas:32981-86-5
Min.Order:0
Negotiable
Type:Manufacturers
inquiryAppearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By
Cas:32981-86-5
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Cas:32981-86-5
Min.Order:1 Kilogram
FOB Price: $1.0 / 100000.0
Type:Lab/Research institutions
inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:32981-86-5
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:32981-86-5
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryNanjing Spring & Autumn Biological Engineering Co., Ltd. Which was founded at 2008, has an R & D team composed very experienced natural products chemists. The company is a high-tech enterprise engaged in functional health care products raw ma
Cas:32981-86-5
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry7-triethylsilyl-10-deacetylbaccatin III
10-deacetylbaccatin III
Conditions | Yield |
---|---|
With sodium periodate In tetrahydrofuran; water at 30 - 40℃; for 144h; | 88% |
With hydrogenchloride In ethanol at 0℃; for 24h; | 67% |
With sodium hypochlorite In acetone; acetonitrile at 20℃; for 2h; |
baccatin III
10-deacetylbaccatin III
Conditions | Yield |
---|---|
With hydrazine hydrate In ethanol for 2h; Ambient temperature; | 87% |
With dihydrogen peroxide; calcium carbonate In tetrahydrofuran for 72h; Ambient temperature; | 57% |
taxol
A
10-deacetylbaccatin III
B
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
C
10-deacetyl-7-epi-baccatin III
Conditions | Yield |
---|---|
With lithium iodide In methanol for 10h; Ambient temperature; | A 58% B 82% C 40% |
With lithium iodide In methanol for 10h; Ambient temperature; | A 58% B 82% C 40% |
taxol
10-deacetylbaccatin III
Conditions | Yield |
---|---|
With hydrazine hydrate In ethanol for 2h; Ambient temperature; | 82% |
Multi-step reaction with 2 steps 1: 81 percent / pyridine / CH2Cl2 / Ambient temperature 2: 22 percent / LiI / methanol / Ambient temperature; 2 weeks View Scheme |
7-O-chloroacetylbaccatin III
10-deacetylbaccatin III
Conditions | Yield |
---|---|
With water; hydrazine In ethanol at 20℃; for 2h; Product distribution / selectivity; | 75% |
7-O-acetylbaccatine III
10-deacetylbaccatin III
Conditions | Yield |
---|---|
With water; hydrazine In ethanol at 20℃; for 2h; Product distribution / selectivity; | 75% |
With sodium methylate at 20℃; for 2h; Product distribution / selectivity; | 75% |
(2aR,4S,4aS,6R,9S,11S,12S,12bS)-6,12b-bis(acetyloxy)-9-({(2R,3S)-3-(benzoylamino)-3-phenyl-2-[(triethylsilyl)oxy]propanoyl}oxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9, 10,11,12,12a,12bdodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate
A
10-deacetylbaccatin III
B
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
C
10-deacetyl-7-epi-baccatin III
Conditions | Yield |
---|---|
With lithium iodide In methanol Ambient temperature; 2 weeks; | A 22% B 71% C 34% |
10-deacetyl-7-epi-baccatin III
10-deacetylbaccatin III
Conditions | Yield |
---|---|
With Bacillus mycoides AS1.182 In acetone at 27℃; for 168h; | 58.9% |
With 1,8-diazabicyclo[5.4.0]undec-7-ene In xylene at 80℃; Product distribution; C-7-epimerization under base conditions; further taxoids; |
10-dehydro-10-deacetylbaccatin III (V)
10-deacetylbaccatin III
Conditions | Yield |
---|---|
With sodium cyanoborohydride | 56% |
7-α-glucosyloxyacetyl paclitaxel
A
10-deacetylbaccatin III
B
10-deacetyl-7-epi-baccatin III
C
baccatin III
D
7-epi-baccatine III
Conditions | Yield |
---|---|
With Synechocystis sp. PCC 6803; BG-11 medium at 25℃; for 168h; Further byproducts.; | A 16% B 10% C 33% D 27% |
7-α-glucosyloxyacetyl paclitaxel
A
10-deacetylbaccatin III
B
taxol
C
baccatin III
Conditions | Yield |
---|---|
With Nicotiana tabacum at 25℃; | A 10% B 25% C 11% |
10-deacetylpaclitaxel
10-deacetylbaccatin III
Conditions | Yield |
---|---|
In dichloromethane | 24% |
7-α-glucosyloxyacetyl paclitaxel
A
10-deacetylbaccatin III
B
10-deacetylpaclitaxel
C
taxol
D
7-epipaclitaxel
Conditions | Yield |
---|---|
With Marchantia polymorpha; BG-11 medium at 25℃; Further byproducts.; | A 8% B 10% C 17% D 8% |
methanol
Cephalomannine
A
7-epi-baccatin III
B
10-deacetylbaccatin III
(2R,3S)-2-Hydroxy-3-((E)-2-methyl-but-2-enoylamino)-3-phenyl-propionic acid methyl ester
D
baccatin III
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In methanol; water for 5h; Ambient temperature; other base; Further byproducts given; | A 4.5 mg B 4.6 mg C 6.6 mg D 4.9 mg |
Cephalomannine
A
7-epi-baccatin III
B
10-deacetylbaccatin III
(2R,3S)-2-Hydroxy-3-((E)-2-methyl-but-2-enoylamino)-3-phenyl-propionic acid methyl ester
D
baccatin III
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In methanol; water for 5h; Ambient temperature; Further byproducts given; | A 4.5 mg B 4.6 mg C 6.6 mg D 4.9 mg |
Cephalomannine
A
7-epi-baccatin III
B
10-deacetylbaccatin III
C
(1Z,3E,9Z)-1-Chlorohexadeca-5,7-diyne-1,3,9-trien-14-ol
D
baccatin III
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In methanol; water for 5h; Ambient temperature; Further byproducts given; | A 4.5 mg B 4.6 mg C 6.6 mg D 4.9 mg |
Cephalomannine
A
10-deacetylbaccatin III
(2R,3S)-2-Hydroxy-3-((E)-2-methyl-but-2-enoylamino)-3-phenyl-propionic acid methyl ester
C
10-Deacetylcephalomannine
D
baccatin III
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In methanol; water for 5h; Ambient temperature; Further byproducts given; | A 4.6 mg B 6.6 mg C 1.6 mg D 4.9 mg |
Cephalomannine
A
10-deacetylbaccatin III
(2R,3S)-2-Hydroxy-3-((E)-2-methyl-but-2-enoylamino)-3-phenyl-propionic acid methyl ester
C
10-deacetyl-7-epi-baccatin III
D
baccatin III
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In methanol; water for 5h; Ambient temperature; Further byproducts given; | A 4.6 mg B 6.6 mg C 3.3 mg D 4.9 mg |
phenyllithium
C28H33Cl3O13
A
10-deacetylbaccatin III
B
baccatin III
Conditions | Yield |
---|---|
In tetrahydrofuran at -78℃; Phenylation; |
baccatin III
A
10-deacetylbaccatin III
B
10-deacetyl-7-epi-baccatin III
Conditions | Yield |
---|---|
With zinc(II) chloride In methanol at 20℃; | A 15 mg B 46 mg |
C29H48O7Si
10-deacetylbaccatin III
Conditions | Yield |
---|---|
Multi-step reaction with 16 steps 1: 91 percent / tetrahydrofuran / -78 °C 2: 94 percent / HCl; H2O; NaI / dioxane 3: 92 percent / pyridine / CH2Cl2 / -30 °C 4: Dess-Martin periodinane / CH2Cl2 5: Et3N 6: 89 percent / ZnCl2 / tetrahydrofuran / -78 °C 7: N,N-diisopropylethylamine / 55 °C 8: NH4F / methanol / 20 °C 9: tetrahydrofuran / -78 °C 10: imidazole / CHCl3 11: 92 percent / pyridine / CH2Cl2 12: 76 percent / KCN / ethanol / 0 °C 13: 95 percent / (i-Pr)2NEt / toluene / 110 °C 14: 89 percent / DMAP 15: 96 percent / TASF / tetrahydrofuran / 0 °C 16: tetrahydrofuran / -78 °C View Scheme |
((1S,5S,6R,7S,8S,9S,12S)-8,9-Dihydroxy-7,11,14,14-tetramethyl-3-oxo-12-triisopropylsilanyloxy-2,4-dioxa-tricyclo[8.3.1.01,5]tetradec-10-en-6-yl)-acetaldehyde
10-deacetylbaccatin III
Conditions | Yield |
---|---|
Multi-step reaction with 14 steps 1: 92 percent / pyridine / CH2Cl2 / -30 °C 2: Dess-Martin periodinane / CH2Cl2 3: Et3N 4: 89 percent / ZnCl2 / tetrahydrofuran / -78 °C 5: N,N-diisopropylethylamine / 55 °C 6: NH4F / methanol / 20 °C 7: tetrahydrofuran / -78 °C 8: imidazole / CHCl3 9: 92 percent / pyridine / CH2Cl2 10: 76 percent / KCN / ethanol / 0 °C 11: 95 percent / (i-Pr)2NEt / toluene / 110 °C 12: 89 percent / DMAP 13: 96 percent / TASF / tetrahydrofuran / 0 °C 14: tetrahydrofuran / -78 °C View Scheme |
10-deacetylbaccatin III
Conditions | Yield |
---|---|
Multi-step reaction with 15 steps 1: 94 percent / HCl; H2O; NaI / dioxane 2: 92 percent / pyridine / CH2Cl2 / -30 °C 3: Dess-Martin periodinane / CH2Cl2 4: Et3N 5: 89 percent / ZnCl2 / tetrahydrofuran / -78 °C 6: N,N-diisopropylethylamine / 55 °C 7: NH4F / methanol / 20 °C 8: tetrahydrofuran / -78 °C 9: imidazole / CHCl3 10: 92 percent / pyridine / CH2Cl2 11: 76 percent / KCN / ethanol / 0 °C 12: 95 percent / (i-Pr)2NEt / toluene / 110 °C 13: 89 percent / DMAP 14: 96 percent / TASF / tetrahydrofuran / 0 °C 15: tetrahydrofuran / -78 °C View Scheme |
10-deacetylbaccatin III
Conditions | Yield |
---|---|
Multi-step reaction with 12 steps 1: Et3N 2: 89 percent / ZnCl2 / tetrahydrofuran / -78 °C 3: N,N-diisopropylethylamine / 55 °C 4: NH4F / methanol / 20 °C 5: tetrahydrofuran / -78 °C 6: imidazole / CHCl3 7: 92 percent / pyridine / CH2Cl2 8: 76 percent / KCN / ethanol / 0 °C 9: 95 percent / (i-Pr)2NEt / toluene / 110 °C 10: 89 percent / DMAP 11: 96 percent / TASF / tetrahydrofuran / 0 °C 12: tetrahydrofuran / -78 °C View Scheme |
((1S,5S,6R,7S,8S,9S,12S)-9-Hydroxy-7,11,14,14-tetramethyl-3-oxo-8-triethylsilanyloxy-12-triisopropylsilanyloxy-2,4-dioxa-tricyclo[8.3.1.01,5]tetradec-10-en-6-yl)-acetaldehyde
10-deacetylbaccatin III
Conditions | Yield |
---|---|
Multi-step reaction with 13 steps 1: Dess-Martin periodinane / CH2Cl2 2: Et3N 3: 89 percent / ZnCl2 / tetrahydrofuran / -78 °C 4: N,N-diisopropylethylamine / 55 °C 5: NH4F / methanol / 20 °C 6: tetrahydrofuran / -78 °C 7: imidazole / CHCl3 8: 92 percent / pyridine / CH2Cl2 9: 76 percent / KCN / ethanol / 0 °C 10: 95 percent / (i-Pr)2NEt / toluene / 110 °C 11: 89 percent / DMAP 12: 96 percent / TASF / tetrahydrofuran / 0 °C 13: tetrahydrofuran / -78 °C View Scheme |
2-((1S,5S,6S,7S,8S,12S)-7,11,14,14-Tetramethyl-3,9-dioxo-8-triethylsilanyloxy-12-triisopropylsilanyloxy-2,4-dioxa-tricyclo[8.3.1.01,5]tetradec-10-en-6-yl)-propenal
10-deacetylbaccatin III
Conditions | Yield |
---|---|
Multi-step reaction with 11 steps 1: 89 percent / ZnCl2 / tetrahydrofuran / -78 °C 2: N,N-diisopropylethylamine / 55 °C 3: NH4F / methanol / 20 °C 4: tetrahydrofuran / -78 °C 5: imidazole / CHCl3 6: 92 percent / pyridine / CH2Cl2 7: 76 percent / KCN / ethanol / 0 °C 8: 95 percent / (i-Pr)2NEt / toluene / 110 °C 9: 89 percent / DMAP 10: 96 percent / TASF / tetrahydrofuran / 0 °C 11: tetrahydrofuran / -78 °C View Scheme |
(1S,5S,6S,7S,8S,12S)-6-((R)-2-Benzyloxymethoxy-1-methylene-pent-4-enyl)-8-hydroxy-7,11,14,14-tetramethyl-12-triisopropylsilanyloxy-2,4-dioxa-tricyclo[8.3.1.01,5]tetradec-10-ene-3,9-dione
10-deacetylbaccatin III
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: tetrahydrofuran / -78 °C 2: imidazole / CHCl3 3: 92 percent / pyridine / CH2Cl2 4: 76 percent / KCN / ethanol / 0 °C 5: 95 percent / (i-Pr)2NEt / toluene / 110 °C 6: 89 percent / DMAP 7: 96 percent / TASF / tetrahydrofuran / 0 °C 8: tetrahydrofuran / -78 °C View Scheme |
(1S,5S,6S,7S,8S,12S)-6-((R)-2-Hydroxy-1-methylene-pent-4-enyl)-7,11,14,14-tetramethyl-8-triethylsilanyloxy-12-triisopropylsilanyloxy-2,4-dioxa-tricyclo[8.3.1.01,5]tetradec-10-ene-3,9-dione
10-deacetylbaccatin III
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1: N,N-diisopropylethylamine / 55 °C 2: NH4F / methanol / 20 °C 3: tetrahydrofuran / -78 °C 4: imidazole / CHCl3 5: 92 percent / pyridine / CH2Cl2 6: 76 percent / KCN / ethanol / 0 °C 7: 95 percent / (i-Pr)2NEt / toluene / 110 °C 8: 89 percent / DMAP 9: 96 percent / TASF / tetrahydrofuran / 0 °C 10: tetrahydrofuran / -78 °C View Scheme |
10-deacetylbaccatin III
triethylsilyl chloride
7-triethylsilyl-10-deacetylbaccatin III
Conditions | Yield |
---|---|
With 1H-imidazole In N,N-dimethyl-formamide | 100% |
With pyridine Ambient temperature; | 98% |
In pyridine at 25℃; for 24h; | 97.7% |
10-deacetylbaccatin III
10-deacetyl-2-(hexahydro)baccatin III
Conditions | Yield |
---|---|
With hydrogen; Rh on carbon In methanol at 35℃; under 25857.4 Torr; for 24h; | 100% |
10-deacetylbaccatin III
Acetyl bromide
Trichloroacetyl chloride
7-trichloroacetylbaccatin III
Conditions | Yield |
---|---|
Stage #1: 10-deacetylbaccatin III; trifluoroacetyl chloride With pyridine In chloroform at 35℃; for 4h; Stage #2: Acetyl bromide In chloroform at 20℃; for 5h; | 100% |
Stage #1: 10-deacetylbaccatin III; trifluoroacetyl chloride With pyridine In chloroform at 35℃; for 4h; Stage #2: Acetyl bromide In chloroform at 20℃; for 5h; | 100% |
10-deacetylbaccatin III
2,2,2-Trichloroethyl chloroformate
7,10-di-(2,2,2-trichloroethyloxycarbonyl)-10-deacetylbaccatin III
Conditions | Yield |
---|---|
With pyridine In dichloromethane at 50℃; under 7500.75 Torr; for 0.0277778h; Concentration; Temperature; Pressure; | 98.4% |
With pyridine In dichloromethane at 2℃; for 2h; Temperature; | 98.9% |
With pyridine at 0 - 20℃; | 91% |
Conditions | Yield |
---|---|
lanthanum(lll) triflate In tetrahydrofuran for 2h; | 97% |
With cerium(III) chloride heptahydrate In tetrahydrofuran at 20℃; for 3h; Inert atmosphere; Cooling with ice; | 96% |
With cerium(III) chloride heptahydrate In tetrahydrofuran at 20℃; for 2h; | 94.4% |
Conditions | Yield |
---|---|
With dmap In pyridine at 23℃; for 20h; Inert atmosphere; | 96% |
In pyridine at 80℃; for 24h; | 30 mg |
10-deacetylbaccatin III
triethylsilyl chloride
7,10,13-tris(triethylsilyl)-10-deacetylbaccatin III
Conditions | Yield |
---|---|
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 40h; silylation; | 96% |
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 47h; silylation; | 96% |
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; | 96% |
10-deacetylbaccatin III
2-Methylpropionic anhydride
10-isobutyloyl 10-deacetylbaccatin III
Conditions | Yield |
---|---|
lanthanum(lll) triflate In tetrahydrofuran | 96% |
With 2,4,6-trimethyl-pyridine; (2S,5S)-2,5-bis[[(2S)-3-(1H-indol-3-yl)-1-(octyloxy)-1-oxopropan-2-ylamino]carbonyl]-1-(pyridin-4-yl)pyrrolidine In tetrahydrofuran; chloroform at -40℃; for 48h; | 89% |
With cerium(III) chloride In tetrahydrofuran at 20℃; for 4h; |
10-deacetylbaccatin III
benzyl chloroformate
C-7,C-10-dibenzyloxycarbonyl-10-deacetyl baccatin III
Conditions | Yield |
---|---|
With dmap In tetrahydrofuran at 40 - 50℃; | 96% |
With dmap In tetrahydrofuran at 40 - 60℃; for 1.5h; | 81% |
With n-hexyllithium In tetrahydrofuran at -44 - 40℃; |
10-deacetylbaccatin III
10-dehydro-10-deacetylbaccatin III (V)
Conditions | Yield |
---|---|
With copper diacetate In methanol | 95% |
10-deacetylbaccatin III
N,N-dimethyl-formamide
(1S,2S,3R,4S,5R,7S,8S,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-10-formyloxy-9-oxo-1,7,13-trihydroxytax-11-ene
Conditions | Yield |
---|---|
With dmap; trifluoromethylsulfonic anhydride at 0℃; | 95% |
With dmap; trifluoromethylsulfonic anhydride for 0.166667h; | 95% |
With pyridine; trifluoromethylsulfonic anhydride; water 1.) -20 deg C, 10 min; 2.) 0 deg C, 3 h; Yield given. Multistep reaction; |
10-deacetylbaccatin III
chloroacetyl chloride
7,10-di-O-chloroacetyl-10-deacetylbaccatin III
Conditions | Yield |
---|---|
With pyridine; dmap In dichloromethane at 25 - 30℃; for 0.5h; | 95% |
Stage #1: 10-deacetylbaccatin III With pyridine; dmap In dichloromethane for 0.166667h; Stage #2: chloroacetyl chloride In dichloromethane at 25 - 30℃; for 0.333333h; | 95% |
With pyridine; dmap In dichloromethane at -5 - 5℃; for 2h; Inert atmosphere; | |
Stage #1: 10-deacetylbaccatin III With pyridine; dmap In dichloromethane for 0.166667h; Stage #2: chloroacetyl chloride In dichloromethane at 5 - 10℃; for 2h; |
10-deacetylbaccatin III
di-tert-butyl dicarbonate
7,10,13-tri-Boc-10-deacetylbaccatin
Conditions | Yield |
---|---|
With dmap In tetrahydrofuran; dichloromethane at 20℃; for 12h; Inert atmosphere; | 95% |
10-deacetylbaccatin III
N,O-bis(triethylsilyl) trifluoroacetamide
Conditions | Yield |
---|---|
With lithium hexamethyldisilazane In tetrahydrofuran; hexane at 0℃; for 0.0833333h; Inert atmosphere; | 95% |
10-deacetylbaccatin III
10-trimethylsilyl-10-deacetyl baccatin III
Conditions | Yield |
---|---|
Stage #1: N,O-bis-trimethylsilyl-trifluoromethyl-acetamide; 10-deacetylbaccatin III In tetrahydrofuran at 25℃; Stage #2: With lithium hexamethyldisilazane In tetrahydrofuran for 0.416667h; | 93% |
10-deacetylbaccatin III
3,5-dinitrobenoyl chloride
A
7,10-(di-3',5'-dinitrobenzoyl)-10-deacetylbaccatin III
B
10-(3',5'-dinitrobenzoyl)-10-deacetylbaccatin III
C
7-(3',5'-dinitrobenzoyl)-10-deacetylbaccatin III
D
7,10,13-(tri-3',5'-dinitrobenzoyl)-10-deacetylbaccatin III
Conditions | Yield |
---|---|
With pyridine In chloroform at 38 - 42℃; | A 93% B n/a C n/a D 0.9% |
10-deacetylbaccatin III
Conditions | Yield |
---|---|
With diethylamino-sulfur trifluoride In tetrahydrofuran at -78℃; for 3h; Molecular sieve; Inert atmosphere; | 93% |
10-deacetylbaccatin III
cinnamic anhydride
Conditions | Yield |
---|---|
With 2,4,6-trimethyl-pyridine; (2S,5S)-2,5-bis[[(2S)-3-(1H-indol-3-yl)-1-(octyloxy)-1-oxopropan-2-ylamino]carbonyl]-1-(pyridin-4-yl)pyrrolidine In tetrahydrofuran; chloroform at -20℃; for 72h; | 93% |
10-deacetylbaccatin III
13-dehydro-10-deacetylbaccatin III
Conditions | Yield |
---|---|
With ozone In methanol; dichloromethane at -78℃; for 0.583333h; | 92% |
With pyridinium chlorochromate In dichloromethane for 0.75h; Ambient temperature; | 79% |
With periodic acid In 1,4-dioxane for 72h; Ambient temperature; | 75% |
With 3-chloro-benzenecarboperoxoic acid In ethyl acetate for 24h; Ambient temperature; |
Conditions | Yield |
---|---|
With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene In tetrahydrofuran at 10℃; for 1h; Reagent/catalyst; Solvent; Temperature; Concentration; Inert atmosphere; | 91.8% |
10-deacetylbaccatin III
10-dehydro 10-deacetyl 7-epibaccatin V
Conditions | Yield |
---|---|
With triethylamine; copper dichloride In ethanol; ethyl acetate at -13 - -1.3℃; for 1h; | 91.3% |
Stage #1: 10-deacetylbaccatin III With triethylamine; copper dichloride In ethanol; ethyl acetate at -17.6 - -1.3℃; for 1h; Stage #2: With trifluoroacetic acid In ethanol; ethyl acetate for 0.25h; Product distribution / selectivity; | |
Stage #1: 10-deacetylbaccatin III With triethylamine; copper dichloride In ethanol; ethyl acetate at -13 - -1.3℃; Inert atmosphere; Stage #2: With trifluoroacetic acid In ethanol; ethyl acetate for 0.25h; | |
With triethylamine; copper dichloride In ethanol; ethyl acetate at -13℃; for 1h; Inert atmosphere; | |
Stage #1: 10-deacetylbaccatin III With triethylamine; copper dichloride In ethanol; ethyl acetate at -13 - -1.3℃; for 1h; Stage #2: With trifluoroacetic acid In ethanol; ethyl acetate for 0.25h; |
10-deacetylbaccatin III
tert-butyldimethylsilyl chloride
7-triethylsilyl-10-deacetylbaccatin III
Conditions | Yield |
---|---|
With pyridine at 25℃; for 17h; | 91% |
10-deacetylbaccatin III
benzoic acid anhydride
10-O-benzoyl-10-deacetylbaccatin III
Conditions | Yield |
---|---|
lanthanum(lll) triflate In tetrahydrofuran | 91% |
With 2,4,6-trimethyl-pyridine; (2S,5S)-2,5-bis[[(2S)-3-(1H-indol-3-yl)-1-(octyloxy)-1-oxopropan-2-ylamino]carbonyl]-1-(pyridin-4-yl)pyrrolidine In tetrahydrofuran; chloroform at -20℃; for 168h; | 84% |
With cerium(III) chloride In tetrahydrofuran at 20℃; for 4h; |
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 23h; | 90.8% |
Conditions | Yield |
---|---|
With pyridine In dichloromethane at 0℃; for 4h; | 90% |
Conditions | Yield |
---|---|
With pyridine In dichloromethane at 35℃; for 27h; | 89.7% |
10-deacetylbaccatin III
carbonic acid dimethyl ester
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene
Conditions | Yield |
---|---|
With dmap; caesium bromide; sodium hydride In tetrahydrofuran; N,N-dimethyl-formamide at -30℃; for 3h; Temperature; Reagent/catalyst; | 89.6% |
10-deacetylbaccatin III
triethylsilyl chloride
7,10-bis(triethylsilyl)-10-deacetylbaccatin III
Conditions | Yield |
---|---|
Stage #1: 10-deacetylbaccatin III; triethylsilyl chloride With dmap; triethylamine In tetrahydrofuran at 25℃; Inert atmosphere; Stage #2: With lithium bromide In tetrahydrofuran at 20 - 70℃; Inert atmosphere; | 89% |
Stage #1: 10-deacetylbaccatin III; triethylsilyl chloride With dmap; triethylamine In tetrahydrofuran at 20℃; for 5.5h; Inert atmosphere; Stage #2: With lithium bromide In tetrahydrofuran at 65 - 70℃; for 7h; | 84% |
Stage #1: 10-deacetylbaccatin III; triethylsilyl chloride With dmap; triethylamine In tetrahydrofuran at 20℃; for 5.5h; Inert atmosphere; Stage #2: With lithium bromide In tetrahydrofuran at 65 - 70℃; for 7h; | 84% |
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