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Josun International Limited

Tobramycin / Tobramycin Base Specification: Non-sterile , USP Particle size: Normal size or Micronized as customer demand Packing: 1kg/tin or 2kg/tin or 5kg/tin MOQ : 1KG Certificated: GMP certificate Sample: 10g is free. Orig

bulk raw material API Tobramycin base ( micronized) Non-sterile 32986-56-4

Cas:32986-56-4

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Hangzhou Dawn Ray Pharmaceutical Co.,Ltd

It conforms to USP/EP. Tobramycin sulfate also can be provided. Appearance:White or almost white powder,Hygroscopic Storage:a cool & dry place protected from light, keep drum close when not in use. Package:25kg/drum Application:Used for medicine o

Tobramycin base

Cas:32986-56-4

Min.Order:100 Gram

Negotiable

Type:Trading Company

inquiry

Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance White to white powder Complies Differential Should meet th

High purity Various Specifications tobramycin CAS:32986-56-4

Cas:32986-56-4

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Tobramycin CAS 32986-56-4 Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chemicals in distributing t

Tobramycin CAS 32986-56-4

Cas:32986-56-4

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Tobramycin

Cas:32986-56-4

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Tobramycin 32986-56-4 GMP Manufacturer

Cas:32986-56-4

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Hangzhou J&H Chemical Co., Ltd.

Supply 32986-56-4 Praziquantel /lowest price 32986-56-4 /Tobramycin hot sale J&H Chemical is dealing with APIs & Intermediates, Heterocyclic compounds, Amino acids and its derivatives, Custom synthesis, and have registered around 50,000 c

Supply 32986-56-4 Praziquantel /lowest price 32986-56-4 /Tobramycin hot sale

Cas:32986-56-4

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

TOBRAMYCIN

Cas:32986-56-4

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem’s R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantiti

Tobramycin

Cas:32986-56-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Tobramycin (base and/or unspecified salts)

Cas:32986-56-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name:Tobramycin (Obracin) CAS NO:32986-56-4 Grade:Medical scientific research and export Molecular formula:C18H37N5O9 Molecular weight:467.51 Product Quality 12 years of chemical raw materials Mature operation of the industry System stabil

Tobramycin (Obracin)/ CAS:32986-56-4/ raw material/ high-quality

Cas:32986-56-4

Min.Order:25 Kilogram

FOB Price: $2.0 / 3.0

Type:Other

inquiry

Henan Tianfu Chemical Co., Ltd.

Factory price Tobramycin CAS 32986-56-4 in stock Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED intermediates (Fluorene,Carbazole,

Factory price Tobramycin CAS 32986-56-4 in stock

Cas:32986-56-4

Min.Order:1 Gram

FOB Price: $50.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Tobramycin

Cas:32986-56-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 32986-56-4 with best quality

Cas:32986-56-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Tobramycin/ LIDE PHARMA- Factory supply / Best price

Cas:32986-56-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Tobramycin CAS 32986-56-4 Tobramycin CAS 32986-56-4 CAS 32986-56-4 Brand: SINOTECH MF C18H37N5O9 MSDS: Aviable MW 467.51 EINECS:251-322-5

Tobramycin

Cas:32986-56-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

Our Adwantage: 1.We have stock so we can delivery quickly at the very day when receive the payment. 2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order. 3.High quality gua

98.5% Pharma Raw Powder Tobramycine For Antimicrobial CAS Number:32986-56-4

Cas:32986-56-4

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:White powder Storage:Keep in dark place,Inert atmosphere,2-8°C Package:25kg/Barrel Application:API Transportation:Express/Sea/Air Port:Any port in china

High purity Tobramycin;32986-56-4;1-epitobramycin;3’-deoxykanamycinb;

Cas:32986-56-4

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

Good Quality Tobramycin CAS 32986-56-4 Tobramycin Powder as Antibacterial

Cas:32986-56-4

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2,Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:off-white powder Storage

High quality Tobramycin

Cas:32986-56-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Leader Biochemical Group

About Our Group Since 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & c

China Biggest Factory Manufacturer Supply Tobramycin CAS 32986-56-4

Cas:32986-56-4

Min.Order:500 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Tobramycin

Cas:32986-56-4

Min.Order:1 Kilogram

FOB Price: $86.0 / 100.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Tobramycin CAS:32986-56-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

Tobramycin CAS:32986-56-4

Cas:32986-56-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Deoxykanamycinb Powder USP Standard

Cas:32986-56-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,

tobramycin CAS NO.: 32986-56-4

Cas:32986-56-4

Min.Order:20 Metric Ton

Negotiable

Type:Trading Company

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

tobramycin CAS 32986-56-4

Cas:32986-56-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:32986-56-4

Cas:32986-56-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Lonwin Chemical Group Limited

Tobramycin CAS: 32986-56-4 Specification Item Specification Appearance white or almost white powder Water ≤8.0% pH 9.0-11.0 Heavy metals ≤0.003% Assay 910ug/mg We

Factory supply Tobramycin

Cas:32986-56-4

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. 3) OEM/ODM Available; 4) Reasonable & Compet

Tobramycin CAS 32986-56-4 with factory price

Cas:32986-56-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Synthetic route

fosfomycin
23155-02-4

fosfomycin

tobramycin
32986-56-4

tobramycin

tobramycin sulfate

tobramycin sulfate

tobramycin
32986-56-4

tobramycin

Conditions
ConditionsYield
Stage #1: tobramycin sulfate
Stage #2: With trifluoroacetic acid In water
tobramycin
32986-56-4

tobramycin

1,3-di(tert-butyloxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine
207857-15-6

1,3-di(tert-butyloxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine

guanidinoboc10-tobramycin

guanidinoboc10-tobramycin

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane; water at 20℃; for 72h;100%
tobramycin
32986-56-4

tobramycin

1,3-di(tert-butyloxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine
207857-15-6

1,3-di(tert-butyloxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine

C73H127N15O29
290360-48-4

C73H127N15O29

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane; water at 20℃; for 72h;100%
tobramycin
32986-56-4

tobramycin

O-3-azido-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[2,6-diazido-2,3,6-trideoxy-α-D-ribo-hexopyranosyl-(1→4)]-1,3-diazido-1,2,3-trideoxy-D-myo-inositol
468065-22-7

O-3-azido-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[2,6-diazido-2,3,6-trideoxy-α-D-ribo-hexopyranosyl-(1→4)]-1,3-diazido-1,2,3-trideoxy-D-myo-inositol

Conditions
ConditionsYield
With TEA; triflic azide; copper(II) sulfate In methanol; dichloromethane100%
With triflic azide; triethylamine; zinc(II) chloride In methanol; dichloromethane; water at 20℃;92%
With triflic azide; copper(II) sulfate; triethylamine83%
With triflic azide; triethylamine; zinc(II) chloride In methanol; dichloromethane; water Inert atmosphere;
With triflic azide; zinc(II) chloride In methanol; dichloromethane; water Inert atmosphere;
tobramycin
32986-56-4

tobramycin

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

di-tert-butyl ((1S,3R,4S,5S,6R)-4-(((2S,3R,4S,5S,6R)-4-((tert-butoxycarbonyl)amino)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-6-(((2R,3R,5S,6R)-3-((tert-butoxycarbonyl)amino)-6-(((tert-butoxycarbonyl)methyl)-5-hydroxytetrahydro-2H-pyran-2-yl)oxy)-5-hydroxycyclohexane-1,3-diyl)dicarbamate)
172950-21-9

di-tert-butyl ((1S,3R,4S,5S,6R)-4-(((2S,3R,4S,5S,6R)-4-((tert-butoxycarbonyl)amino)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-6-(((2R,3R,5S,6R)-3-((tert-butoxycarbonyl)amino)-6-(((tert-butoxycarbonyl)methyl)-5-hydroxytetrahydro-2H-pyran-2-yl)oxy)-5-hydroxycyclohexane-1,3-diyl)dicarbamate)

Conditions
ConditionsYield
With triethylamine In water at 60℃; for 0.666667h;98%
With triethylamine In methanol; water at 55℃;98%
With triethylamine In methanol; water at 55℃;97%
tobramycin
32986-56-4

tobramycin

5-benzoyl-3-(cyclopent-1-en-1-yl)-5-phenyl-1,5-dihydro-4H-pyrazol-4-one

5-benzoyl-3-(cyclopent-1-en-1-yl)-5-phenyl-1,5-dihydro-4H-pyrazol-4-one

C25H41N5O10

C25H41N5O10

Conditions
ConditionsYield
In dimethyl sulfoxide at 20℃; for 24h; Solvent;92%
tobramycin
32986-56-4

tobramycin

benzyl chloroformate
501-53-1

benzyl chloroformate

1,3,2',6',3''-pentakis(N-benzyloxycarbonyl)-3'-deoxykanamycin B
61093-69-4

1,3,2',6',3''-pentakis(N-benzyloxycarbonyl)-3'-deoxykanamycin B

Conditions
ConditionsYield
With sodium carbonate90%
With sodium carbonate In water
With sodium carbonate In acetone at 0℃;
tobramycin
32986-56-4

tobramycin

N-(benzyloxycarbonyloxy)phthalimide
65162-83-6

N-(benzyloxycarbonyloxy)phthalimide

6'-N-benzyloxycarbonyltobramycin

6'-N-benzyloxycarbonyltobramycin

Conditions
ConditionsYield
With potassium carbonate In methanol; water at 20℃; for 18h;64%
azidoacetic acid succinimidyl ester

azidoacetic acid succinimidyl ester

tobramycin
32986-56-4

tobramycin

6'-N-azidoacetyl tobramycin
1220984-19-9

6'-N-azidoacetyl tobramycin

Conditions
ConditionsYield
With potassium carbonate In methanol; water for 20h;63%
tobramycin
32986-56-4

tobramycin

magnesium acetate
142-72-3, 92123-19-8

magnesium acetate

3-N-acetyltobramycin
68244-01-9

3-N-acetyltobramycin

Conditions
ConditionsYield
With Tmed buffer; ATP In water for 12h; aminoglycoside phosphotransferase;62%
tobramycin
32986-56-4

tobramycin

N-<<(benzyloxy)carbonyl>oxy>-5-norbornene-2,3-dicarboximide
62210-73-5

N-<<(benzyloxy)carbonyl>oxy>-5-norbornene-2,3-dicarboximide

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

C36H59N5O15

C36H59N5O15

Conditions
ConditionsYield
Stage #1: tobramycin With zinc(II) acetate dihydrate In dimethyl sulfoxide at 21℃;
Stage #2: N-<<(benzyloxy)carbonyl>oxy>-5-norbornene-2,3-dicarboximide In dimethyl sulfoxide at 21℃; for 24h;
Stage #3: di-tert-butyl dicarbonate In dimethyl sulfoxide at 21℃; for 4h;
57%
tobramycin
32986-56-4

tobramycin

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

C33H61N5O15

C33H61N5O15

Conditions
ConditionsYield
Stage #1: tobramycin With zinc(II) acetate dihydrate In dimethyl sulfoxide at 21℃;
Stage #2: di-tert-butyl dicarbonate In dimethyl sulfoxide at 21℃; for 5h;
53%
tobramycin
32986-56-4

tobramycin

N-[(S)-4-benzyloxycarbonylamino-2-hydroxy-butyryloxy]succinimide
40371-52-6

N-[(S)-4-benzyloxycarbonylamino-2-hydroxy-butyryloxy]succinimide

6'-N-CbzAHB tobramycin
1312471-07-0

6'-N-CbzAHB tobramycin

Conditions
ConditionsYield
Stage #1: tobramycin With zinc diacetate In water; N,N-dimethyl-formamide at 20℃; for 16h;
Stage #2: N-[(S)-4-benzyloxycarbonylamino-2-hydroxy-butyryloxy]succinimide In water; N,N-dimethyl-formamide for 24h;
31%
tobramycin
32986-56-4

tobramycin

2,4-dinitrophenylthioglycolic acid N-hydroxy succinimide ester
93801-70-8

2,4-dinitrophenylthioglycolic acid N-hydroxy succinimide ester

N-{(2R,3S,5R,6R)-5-Amino-6-[(1R,2S,3S,4R,6S)-4,6-diamino-3-((2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-2-hydroxy-cyclohexyloxy]-3-hydroxy-tetrahydro-pyran-2-ylmethyl}-2-(2,4-dinitro-phenylsulfanyl)-acetamide
93801-67-3

N-{(2R,3S,5R,6R)-5-Amino-6-[(1R,2S,3S,4R,6S)-4,6-diamino-3-((2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-2-hydroxy-cyclohexyloxy]-3-hydroxy-tetrahydro-pyran-2-ylmethyl}-2-(2,4-dinitro-phenylsulfanyl)-acetamide

Conditions
ConditionsYield
In water; N,N-dimethyl-formamide at 0℃; for 2h; pH=10.76;28.3%
tobramycin
32986-56-4

tobramycin

acetic anhydride
108-24-7

acetic anhydride

A

1,3,2',6',3''-penta-N-acetyltobramycin
33985-51-2

1,3,2',6',3''-penta-N-acetyltobramycin

B

1,2',6',3''-tetra-N-acetyltobramycin

1,2',6',3''-tetra-N-acetyltobramycin

C

1,3,2',6'-tetra-N-acetyltobramycin

1,3,2',6'-tetra-N-acetyltobramycin

D

1,2',6'-tri-N-acetyltobramycin

1,2',6'-tri-N-acetyltobramycin

Conditions
ConditionsYield
In methanol for 0.166667h; Ambient temperature; Yields of byproduct given;A 26.9%
B n/a
C n/a
D n/a
In methanol for 0.166667h; Ambient temperature; Yields of byproduct given;A n/a
B 7.4%
C n/a
D n/a
In methanol for 0.166667h; Ambient temperature; Yield given. Yields of byproduct given;
tobramycin
32986-56-4

tobramycin

N-(Benzyloxycarbonyloxy)succinimide
13139-17-8

N-(Benzyloxycarbonyloxy)succinimide

[2-[4-amino-3-(4-amino-3,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-6-benzyloxycarbonylamino-2-hydroxy-cyclohexyloxy]-6-(benzyloxycarbonylamino-methyl)-5-hydroxy-tetrahydro-pyran-3-yl]-carbamic acid benzyl ester

[2-[4-amino-3-(4-amino-3,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-6-benzyloxycarbonylamino-2-hydroxy-cyclohexyloxy]-6-(benzyloxycarbonylamino-methyl)-5-hydroxy-tetrahydro-pyran-3-yl]-carbamic acid benzyl ester

Conditions
ConditionsYield
Stage #1: tobramycin With zinc diacetate In dimethyl sulfoxide for 12h;
Stage #2: N-(Benzyloxycarbonyloxy)succinimide In dimethyl sulfoxide for 2h;
25%
tobramycin
32986-56-4

tobramycin

[[(tetramethyl-4,4-difluoro-4-bora-3a,4a-diazaindacene)methyl]phenoxy]ethyl (4-nitrophenyl) carbonate

[[(tetramethyl-4,4-difluoro-4-bora-3a,4a-diazaindacene)methyl]phenoxy]ethyl (4-nitrophenyl) carbonate

C40H58BF2N7O12

C40H58BF2N7O12

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide Darkness;17%
tobramycin
32986-56-4

tobramycin

N-acetyl-DL-homocysteinethiolactone
1195-16-0, 768351-04-8

N-acetyl-DL-homocysteinethiolactone

2-Acetylamino-N-{(2R,3S,5R,6R)-5-amino-6-[(1R,2S,3S,4R,6S)-4,6-diamino-3-((2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-2-hydroxy-cyclohexyloxy]-3-hydroxy-tetrahydro-pyran-2-ylmethyl}-4-mercapto-butyramide

2-Acetylamino-N-{(2R,3S,5R,6R)-5-amino-6-[(1R,2S,3S,4R,6S)-4,6-diamino-3-((2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-2-hydroxy-cyclohexyloxy]-3-hydroxy-tetrahydro-pyran-2-ylmethyl}-4-mercapto-butyramide

Conditions
ConditionsYield
In water for 30h; pH=10.12-10.25; Yield given;
tobramycin
32986-56-4

tobramycin

N-acetyl-DL-homocysteinethiolactone
1195-16-0, 768351-04-8

N-acetyl-DL-homocysteinethiolactone

α-bromoacetophenone
70-11-1

α-bromoacetophenone

C32H52N6O12S

C32H52N6O12S

Conditions
ConditionsYield
With hydrogenchloride 1.) 20110.12-10.25, 30 min; 2.) pH=7.5, water, THF, 0 deg C, 2 h; Yield given. Multistep reaction;
tobramycin
32986-56-4

tobramycin

acetic anhydride
108-24-7

acetic anhydride

penta-N-penta-O-acetyltobramycin
144727-30-0

penta-N-penta-O-acetyltobramycin

Conditions
ConditionsYield
With pyridine
tobramycin
32986-56-4

tobramycin

benzyl chloroformate
501-53-1

benzyl chloroformate

6'-N-benzyloxycarbonyltobramycin

6'-N-benzyloxycarbonyltobramycin

Conditions
ConditionsYield
With benzotriazol-1-ol; triethylamine 1.) dioxane, RT, 30 min, 2.) dioxane, water, RT, 20 h; Yield given. Multistep reaction;
tobramycin
32986-56-4

tobramycin

C28H49N10O15P

C28H49N10O15P

Conditions
ConditionsYield
at 37℃; aminoglycoside-4'-nucleotidyltransferaze of Bacillus brevis, MgCl2, potassium phosphate buffer (pH 6.0);
tobramycin
32986-56-4

tobramycin

(2S,3R,5S,6R)-4-Azido-2-[(2S,3R,4S,6R)-4,6-diazido-3-((2R,3R,5S,6R)-3-azido-6-azidomethyl-5-hydroxy-tetrahydro-pyran-2-yloxy)-2-hydroxy-cyclohexyloxy]-6-hydroxymethyl-tetrahydro-pyran-3,5-diol

(2S,3R,5S,6R)-4-Azido-2-[(2S,3R,4S,6R)-4,6-diazido-3-((2R,3R,5S,6R)-3-azido-6-azidomethyl-5-hydroxy-tetrahydro-pyran-2-yloxy)-2-hydroxy-cyclohexyloxy]-6-hydroxymethyl-tetrahydro-pyran-3,5-diol

Conditions
ConditionsYield
With triflic azide; triethylamine; zinc(II) chloride In methanol; dichloromethane; water
tobramycin
32986-56-4

tobramycin

3,2',6'-tris(N-benzyloxycarbonyl)-3'-deoxy-3''-N-(trifluoroacetyl)kanamycin B
103842-08-6

3,2',6'-tris(N-benzyloxycarbonyl)-3'-deoxy-3''-N-(trifluoroacetyl)kanamycin B

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: Zn(OAc)2*2H2O / dimethylsulfoxide / 12 h
1.2: 25 percent / dimethylsulfoxide / 2 h
2.1: 60 percent / dimethylsulfoxide / 2 h
View Scheme
tobramycin
32986-56-4

tobramycin

C21H43N7O11

C21H43N7O11

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: Zn(OAc)2*2H2O / dimethylsulfoxide / 12 h
1.2: 25 percent / dimethylsulfoxide / 2 h
2.1: 60 percent / dimethylsulfoxide / 2 h
3.1: 11 mg / tetrahydrofuran; H2O / 96 h / 20 °C
4.1: aq. NaOH / methanol / 20 h
5.1: 4.5 mg / H2 / 10 percent Pd/C / dioxane; H2O; acetic acid / 0.67 h
View Scheme
tobramycin
32986-56-4

tobramycin

C53H67N7O19
533923-31-8

C53H67N7O19

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: Zn(OAc)2*2H2O / dimethylsulfoxide / 12 h
1.2: 25 percent / dimethylsulfoxide / 2 h
2.1: 60 percent / dimethylsulfoxide / 2 h
3.1: 11 mg / tetrahydrofuran; H2O / 96 h / 20 °C
4.1: aq. NaOH / methanol / 20 h
View Scheme
tobramycin
32986-56-4

tobramycin

C62H70F3N7O21
533923-30-7

C62H70F3N7O21

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: Zn(OAc)2*2H2O / dimethylsulfoxide / 12 h
1.2: 25 percent / dimethylsulfoxide / 2 h
2.1: 60 percent / dimethylsulfoxide / 2 h
3.1: 11 mg / tetrahydrofuran; H2O / 96 h / 20 °C
View Scheme

Raw Materials

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