Unique advantages of Tolterodine tartrate Cas 124937-52-6 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:Cool dry place Package:100g,1kg/foi
Cas:124937-52-6
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Cas:124937-52-6
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryProduct Name: Tolterodine tartrate CAS No.:124937-52-6 Molecular Formula:C22H31NO.C4H6O6 Grade Standard:Medicine Grade Purity:99%min Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package:25kg/drum Applicati
Cas:124937-52-6
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White or off-white powder Storage:Store in sealed containers
Cas:124937-52-6
Min.Order:100 Gram
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inquiryAppearance:white-to-off-white crystalline powder Storage:Room temperature Package:25kg/drum Application:API Transportation:Express/Sea/Air Port:Any port in china
Cas:124937-52-6
Min.Order:1 Kilogram
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Min.Order:1 Gram
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Cas:124937-52-6
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inquiryProduct Detail Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,
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Product Name: Tolterodine tartrate Synonyms: 124937-52-6;Detrol LA;PNU-200583E;(±)-Tolterodine-d14 Tartrate;Tolterodine(Detrol);2-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-methylphenol(2R,3R)-2,3-dihydroxybutanedioate;Tolterodin
Cas:124937-52-6
Min.Order:100 Gram
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inquiryAppearance:off-white to white solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for Synthesis API and Research Transportation:As customer request Port:Qingda
Cas:124937-52-6
Min.Order:0 Metric Ton
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inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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Min.Order:1 Kilogram
FOB Price: $1.0 / 100000.0
Type:Lab/Research institutions
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Min.Order:1 Kilogram
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Min.Order:100 Milligram
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Min.Order:0 Metric Ton
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A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:124937-52-6
Min.Order:4 Kilogram
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inquiry124937-52-6 Appearance:white powder Storage:room temperature Package:according to customers' requirements Application:Pharma intermediates Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or CNF ect...)or according to y
Advantage 1: The product passed the professional production process and quality inspection, the purity is 99% +. 2: Highly qualified engineers to provide technical documents and service. 3: We could provide sample for your test. 4: High qualit
Cas:124937-52-6
Min.Order:100 Gram
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Type:Lab/Research institutions
inquiryL-Tartaric acid
tolterodine tartrate
Conditions | Yield |
---|---|
Stage #1: N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropylamine hydrochloride With sodium carbonate; sodium hydroxide In dichloromethane; water at 20℃; for 1h; Stage #2: L-Tartaric acid In methanol; acetone for 1h; Reflux; | 88% |
Stage #1: N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropylamine hydrochloride With sodium carbonate; sodium hydroxide In dichloromethane; water at 0 - 20℃; for 1h; Stage #2: L-Tartaric acid In methanol; acetone at 0℃; for 2h; Reflux; | 30% |
Stage #1: N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropylamine hydrochloride With sodium hydroxide In dichloromethane; water at 25 - 35℃; for 0.0833333 - 0.166667h; Stage #2: L-Tartaric acid In methanol; dichloromethane; water; acetonitrile at 0 - 35℃; for 6.58333 - 13h; Heating / reflux; | |
Stage #1: N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropylamine hydrochloride With sodium carbonate; sodium hydroxide In dichloromethane; water Stage #2: L-Tartaric acid In ethanol at 0 - 70℃; | n/a |
3-(2-hydroxy-5-methylphenyl)-N,N-diisopropyl-3-phenylpropan-1-aminium bromide
L-Tartaric acid
tolterodine tartrate
Conditions | Yield |
---|---|
Stage #1: 3-(2-hydroxy-5-methylphenyl)-N,N-diisopropyl-3-phenylpropan-1-aminium bromide With sodium hydroxide In dichloromethane; water Stage #2: L-Tartaric acid In ethanol at 60 - 85℃; | 39% |
(+/-)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propanamide
L-Tartaric acid
tolterodine tartrate
Conditions | Yield |
---|---|
Stage #1: (+/-)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propanamide With sodium bis(2-methoxyethoxy)aluminium dihydride In toluene at 5 - 40℃; for 6h; Cooling with ice; Stage #2: L-Tartaric acid In ethanol at 0 - 70℃; Reflux; | 37% |
Conditions | Yield |
---|---|
In ethanol at 60 - 85℃; | 18% |
In ethanol at 0 - 80℃; for 5h; Resolution of racemate; | |
In methanol; acetone; toluene at 20 - 60℃; for 12.5h; Resolution of racemate; | n/a |
In ethanol Product distribution / selectivity; |
L-Tartaric acid
tolterodine tartrate
Conditions | Yield |
---|---|
Stage #1: tolterodine hydrobromide With potassium hydroxide In water; ethyl acetate for 0.25 - 0.5h; Stage #2: L-Tartaric acid In ethanol; ethyl acetate at 0℃; for 5 - 17h; Product distribution / selectivity; |
Conditions | Yield |
---|---|
In ethanol at 25 - 30℃; for 0.5h; Product distribution / selectivity; Resolution of racemate; |
(+/-)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propanamide
L-Tartaric acid
A
(S)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine L-hydrogen tartrate
B
tolterodine tartrate
Conditions | Yield |
---|---|
Stage #1: (+/-)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propanamide With sodium bis(2-methoxyethoxy)aluminium dihydride In toluene at 70℃; for 6.08333h; Inert atmosphere; Cooling with ice; Stage #2: With sodium hydroxide In acetone; toluene at 40 - 60℃; for 0.25h; Stage #3: L-Tartaric acid In methanol at 0℃; Product distribution / selectivity; Reflux; | A n/a B n/a |
Stage #1: (+/-)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propanamide With sodium bis(2-methoxyethoxy)aluminium dihydride In toluene at 5 - 40℃; for 6h; Cooling with ice; Stage #2: L-Tartaric acid In isopropyl alcohol at 20 - 75℃; for 3.5h; Product distribution / selectivity; | A n/a B n/a |
L-Tartaric acid
A
(S)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine L-hydrogen tartrate
B
tolterodine tartrate
Conditions | Yield |
---|---|
In ethanol at 0 - 70℃; | A n/a B n/a |
N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propylamine L-tartrate
L-Tartaric acid
tolterodine tartrate
Conditions | Yield |
---|---|
In water; isopropyl alcohol at 20 - 65℃; Purification / work up; Resolution of racemate; Reflux; | n/a |
A
(S)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine L-hydrogen tartrate
B
tolterodine tartrate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: hydrogen / 5%-palladium/activated carbon / water; 2-methyltetrahydrofuran / 2.5 h / 55 °C / 750.08 Torr 2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 6 h / 5 - 40 °C / Cooling with ice 2.2: 3.5 h / 20 - 75 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: hydrogen / 5%-palladium/activated carbon / water; 2-methyltetrahydrofuran / 2.5 h / 55 °C / 750.08 Torr 2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 6 h / 5 - 40 °C / Cooling with ice 2.2: 20 - 60 °C 3.1: ethanol / 0 - 70 °C View Scheme |
tolterodine tartrate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: hydrogen / 5%-palladium/activated carbon / water; 2-methyltetrahydrofuran / 2.5 h / 55 °C / 750.08 Torr 2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 6 h / 5 - 40 °C / Cooling with ice 2.2: 0 - 70 °C / Reflux View Scheme | |
Multi-step reaction with 3 steps 1.1: hydrogen / 5%-palladium/activated carbon / water; 2-methyltetrahydrofuran / 2.5 h / 55 °C / 750.08 Torr 2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 6 h / 5 - 40 °C / Cooling with ice 2.2: 20 - 60 °C 3.1: sodium hydroxide; sodium carbonate / dichloromethane; water 3.2: 0 - 70 °C View Scheme |
(+/-)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propanamide
A
(S)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine L-hydrogen tartrate
B
tolterodine tartrate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 6 h / 5 - 40 °C / Cooling with ice 1.2: 20 - 60 °C 2.1: ethanol / 0 - 70 °C View Scheme |
tolterodine tartrate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: triethylamine / water / 2 h / 0 °C 2.1: acetonitrile / 12 h / Reflux 3.1: sodium hydroxide / methanol; water / 4 h / Reflux 3.2: 1 h / 20 °C 4.1: sodium hydroxide; sodium carbonate / dichloromethane; water / 1 h / 20 °C 4.2: 1 h / Reflux View Scheme |
1-phenyl-1,3-propanediol
tolterodine tartrate
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: iron(III) chloride hexahydrate / dichloromethane / 24 h / Reflux 2.1: sodium hydroxide / dichloromethane; water / 1 h / 40 °C 3.1: triethylamine / water / 2 h / 0 °C 4.1: acetonitrile / 12 h / Reflux 5.1: sodium hydroxide / methanol; water / 4 h / Reflux 5.2: 1 h / 20 °C 6.1: sodium hydroxide; sodium carbonate / dichloromethane; water / 1 h / 20 °C 6.2: 1 h / Reflux View Scheme |
3-phenyl-3-(2'-hydroxy-5'-methyl)phenylpropanol-1
tolterodine tartrate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: sodium hydroxide / dichloromethane; water / 1 h / 40 °C 2.1: triethylamine / water / 2 h / 0 °C 3.1: acetonitrile / 12 h / Reflux 4.1: sodium hydroxide / methanol; water / 4 h / Reflux 4.2: 1 h / 20 °C 5.1: sodium hydroxide; sodium carbonate / dichloromethane; water / 1 h / 20 °C 5.2: 1 h / Reflux View Scheme |
tolterodine tartrate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: acetonitrile / 12 h / Reflux 2.1: sodium hydroxide / methanol; water / 4 h / Reflux 2.2: 1 h / 20 °C 3.1: sodium hydroxide; sodium carbonate / dichloromethane; water / 1 h / 20 °C 3.2: 1 h / Reflux View Scheme |
ethyl 3-oxo-3-phenylpropionate
tolterodine tartrate
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: sodium tetrahydroborate / methanol / 1 h / 20 °C 2.1: iron(III) chloride hexahydrate / dichloromethane / 24 h / Reflux 3.1: sodium hydroxide / dichloromethane; water / 1 h / 40 °C 4.1: triethylamine / water / 2 h / 0 °C 5.1: acetonitrile / 12 h / Reflux 6.1: sodium hydroxide / methanol; water / 4 h / Reflux 6.2: 1 h / 20 °C 7.1: sodium hydroxide; sodium carbonate / dichloromethane; water / 1 h / 20 °C 7.2: 1 h / Reflux View Scheme |
6-methylcoumarin
tolterodine tartrate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: (R)-(6,6’-dimethoxybiphenyl-2,2’-diyl)bis[bis(3-fluoro-4-trifluoromethylphenyl)phosphine]; chlorobis(ethylene)rhodium(I) dimer; sodium hydrogencarbonate / toluene; water / 36 h / 25 °C / Schlenk technique; Inert atmosphere 2.1: citric acid; diisobutylaluminium hydride / toluene; hexane; water; ethyl acetate / -25 - 20 °C / Inert atmosphere 3.1: formic acid; Cp*IrCl(8-quinolinolate) / tetrahydrofuran / 20 h / 0 - 50 °C / Schlenk technique; Inert atmosphere 3.2: 4 h / 0 - 80 °C View Scheme |
phenylboronic acid
tolterodine tartrate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: (R)-(6,6’-dimethoxybiphenyl-2,2’-diyl)bis[bis(3-fluoro-4-trifluoromethylphenyl)phosphine]; chlorobis(ethylene)rhodium(I) dimer; sodium hydrogencarbonate / toluene; water / 36 h / 25 °C / Schlenk technique; Inert atmosphere 2.1: citric acid; diisobutylaluminium hydride / toluene; hexane; water; ethyl acetate / -25 - 20 °C / Inert atmosphere 3.1: formic acid; Cp*IrCl(8-quinolinolate) / tetrahydrofuran / 20 h / 0 - 50 °C / Schlenk technique; Inert atmosphere 3.2: 4 h / 0 - 80 °C View Scheme |
(R)-6-methyl-4-phenyl-3,4-dihydrochromen-2-one
tolterodine tartrate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: citric acid; diisobutylaluminium hydride / toluene; hexane; water; ethyl acetate / -25 - 20 °C / Inert atmosphere 2.1: formic acid; Cp*IrCl(8-quinolinolate) / tetrahydrofuran / 20 h / 0 - 50 °C / Schlenk technique; Inert atmosphere 2.2: 4 h / 0 - 80 °C View Scheme |
(4R)-6-methyl-4-phenylchroman-2-ol
L-Tartaric acid
diisopropylamine
tolterodine tartrate
Conditions | Yield |
---|---|
Stage #1: (4R)-6-methyl-4-phenylchroman-2-ol; diisopropylamine With formic acid; Cp*IrCl(8-quinolinolate) In tetrahydrofuran at 0 - 50℃; for 20h; Schlenk technique; Inert atmosphere; Stage #2: L-Tartaric acid In ethanol at 0 - 80℃; for 4h; | 940.7 mg |
3-(2-benzyloxy-5-methylphenyl)-3-phenylpropanol
tolterodine tartrate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: triethylamine; dmap / dichloromethane / 2 h / 20 °C 2.1: acetonitrile / 16 h / Reflux 3.1: hydrogen; palladium on activated charcoal / methanol / 19 h 4.1: hydrogenchloride / methanol / 0.5 h / 0 °C 5.1: sodium hydroxide; sodium carbonate / dichloromethane; water / 1 h / 0 - 20 °C 5.2: 2 h / 0 °C / Reflux View Scheme |
tolterodine tartrate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: acetonitrile / 16 h / Reflux 2.1: hydrogen; palladium on activated charcoal / methanol / 19 h 3.1: hydrogenchloride / methanol / 0.5 h / 0 °C 4.1: sodium hydroxide; sodium carbonate / dichloromethane; water / 1 h / 0 - 20 °C 4.2: 2 h / 0 °C / Reflux View Scheme |
N,N-diisopropyl-3-(2-benzyloxy-5-methylphenyl)-3-phenylpropylamine
tolterodine tartrate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: hydrogen; palladium on activated charcoal / methanol / 19 h 2.1: hydrogenchloride / methanol / 0.5 h / 0 °C 3.1: sodium hydroxide; sodium carbonate / dichloromethane; water / 1 h / 0 - 20 °C 3.2: 2 h / 0 °C / Reflux View Scheme |
N,N-diiso-propyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine
tolterodine tartrate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: hydrogenchloride / methanol / 0.5 h / 0 °C 2.1: sodium hydroxide; sodium carbonate / dichloromethane; water / 1 h / 0 - 20 °C 2.2: 2 h / 0 °C / Reflux View Scheme |
6-methyl-4-phenyl-3,4-dihydrocoumarin
tolterodine tartrate
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: potassium carbonate / acetone / 2 h / Reflux 1.2: 2 h / Reflux 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C 3.1: triethylamine; dmap / dichloromethane / 2 h / 20 °C 4.1: acetonitrile / 16 h / Reflux 5.1: hydrogen; palladium on activated charcoal / methanol / 19 h 6.1: hydrogenchloride / methanol / 0.5 h / 0 °C 7.1: sodium hydroxide; sodium carbonate / dichloromethane; water / 1 h / 0 - 20 °C 7.2: 2 h / 0 °C / Reflux View Scheme |
methyl 3-(2-benzyloxy-5-methylphenyl)-3-phenylpropionate
tolterodine tartrate
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C 2.1: triethylamine; dmap / dichloromethane / 2 h / 20 °C 3.1: acetonitrile / 16 h / Reflux 4.1: hydrogen; palladium on activated charcoal / methanol / 19 h 5.1: hydrogenchloride / methanol / 0.5 h / 0 °C 6.1: sodium hydroxide; sodium carbonate / dichloromethane; water / 1 h / 0 - 20 °C 6.2: 2 h / 0 °C / Reflux View Scheme |
benzyl bromide
tolterodine tartrate
(R)-3-(2-(benzyloxy)-5-methylphenyl)-N,N-diisopropyl-3-phenylpropan-1-amine
Conditions | Yield |
---|---|
Stage #1: tolterodine tartrate With sodium carbonate; sodium hydroxide In dichloromethane; water at 0 - 20℃; for 0.583333h; Stage #2: benzyl bromide With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 13h; | 100% |
3,6-dichloro-2,5-dihydroxy-1,4-benzoquinone
tolterodine tartrate
Conditions | Yield |
---|---|
In acetonitrile at 25℃; |
2,3-dicyano-5,6-dichloro-p-benzoquinone
tolterodine tartrate
Conditions | Yield |
---|---|
In acetonitrile at 25℃; |
tolterodine tartrate
(R)-3-(2-(benzyloxy)-5-methylphenyl)-N,N-diisopropyl-3-phenylpropan-1-amine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydroxide; sodium carbonate / water; dichloromethane / 0.58 h / 0 - 20 °C 2: potassium carbonate / N,N-dimethyl-formamide / 13 h / 20 °C View Scheme |
tolterodine tartrate
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: sodium hydroxide; sodium carbonate / water; dichloromethane / 0.58 h / 0 - 20 °C 2: potassium carbonate / N,N-dimethyl-formamide / 13 h / 20 °C 3: ammonium cerium (IV) nitrate / water; acetonitrile / 4.08 h / 0 - 20 °C 4: sodium tetrahydroborate; methanol / 13 h / 0 - 20 °C 5: thionyl chloride / dichloromethane / 2 h / 20 °C 6: N,N-dimethyl-formamide / 15 h / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: sodium hydroxide; sodium carbonate / dichloromethane; water / 0.58 h / 0 - 20 °C 1.2: 13 h / 20 °C 2.1: ammonium cerium (IV) nitrate / acetonitrile; water / 4 h / 0 - 20 °C 3.1: sodium tetrahydroborate / methanol / 13 h / 0 - 20 °C 4.1: thionyl chloride / dichloromethane / 2 h / 20 °C 5.1: N,N-dimethyl-formamide / 15 h / 20 °C View Scheme |
tolterodine tartrate
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: sodium hydroxide; sodium carbonate / water; dichloromethane / 0.58 h / 0 - 20 °C 2.1: potassium carbonate / N,N-dimethyl-formamide / 13 h / 20 °C 3.1: ammonium cerium (IV) nitrate / water; acetonitrile / 4.08 h / 0 - 20 °C 4.1: sodium tetrahydroborate; methanol / 13 h / 0 - 20 °C 5.1: thionyl chloride / dichloromethane / 2 h / 20 °C 6.1: N,N-dimethyl-formamide / 15 h / 20 °C 7.1: diisobutylaluminium hydride / toluene / 12 h / -78 °C 7.2: 2.5 h / -78 - 0 °C 8.1: triethylamine / dichloromethane / 0.33 h / 0 - 20 °C View Scheme | |
Multi-step reaction with 7 steps 1.1: sodium hydroxide; sodium carbonate / dichloromethane; water / 0.58 h / 0 - 20 °C 1.2: 13 h / 20 °C 2.1: ammonium cerium (IV) nitrate / acetonitrile; water / 4 h / 0 - 20 °C 3.1: sodium tetrahydroborate / methanol / 13 h / 0 - 20 °C 4.1: thionyl chloride / dichloromethane / 2 h / 20 °C 5.1: N,N-dimethyl-formamide / 15 h / 20 °C 6.1: diisobutylaluminium hydride / toluene / 12 h / -78 °C 6.2: 2.5 h / -78 - 0 °C 7.1: triethylamine / dichloromethane / 0.33 h / 0 - 20 °C View Scheme |
tolterodine tartrate
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: sodium hydroxide; sodium carbonate / water; dichloromethane / 0.58 h / 0 - 20 °C 2.1: potassium carbonate / N,N-dimethyl-formamide / 13 h / 20 °C 3.1: ammonium cerium (IV) nitrate / water; acetonitrile / 4.08 h / 0 - 20 °C 4.1: sodium tetrahydroborate; methanol / 13 h / 0 - 20 °C 5.1: thionyl chloride / dichloromethane / 2 h / 20 °C 6.1: N,N-dimethyl-formamide / 15 h / 20 °C 7.1: diisobutylaluminium hydride / toluene / 12 h / -78 °C 7.2: 2.5 h / -78 - 0 °C 8.1: triethylamine / dichloromethane / 0.33 h / 0 - 20 °C 9.1: 10 wt% Pd(OH)2 on carbon; hydrogen / ethanol / 16 h View Scheme | |
Multi-step reaction with 8 steps 1.1: sodium hydroxide; sodium carbonate / dichloromethane; water / 0.58 h / 0 - 20 °C 1.2: 13 h / 20 °C 2.1: ammonium cerium (IV) nitrate / acetonitrile; water / 4 h / 0 - 20 °C 3.1: sodium tetrahydroborate / methanol / 13 h / 0 - 20 °C 4.1: thionyl chloride / dichloromethane / 2 h / 20 °C 5.1: N,N-dimethyl-formamide / 15 h / 20 °C 6.1: diisobutylaluminium hydride / toluene / 12 h / -78 °C 6.2: 2.5 h / -78 - 0 °C 7.1: triethylamine / dichloromethane / 0.33 h / 0 - 20 °C 8.1: hydrogen; 10 wt% Pd(OH)2 on carbon / ethanol / 16 h View Scheme |
tolterodine tartrate
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1.1: sodium hydroxide; sodium carbonate / water; dichloromethane / 0.58 h / 0 - 20 °C 2.1: potassium carbonate / N,N-dimethyl-formamide / 13 h / 20 °C 3.1: ammonium cerium (IV) nitrate / water; acetonitrile / 4.08 h / 0 - 20 °C 4.1: sodium tetrahydroborate; methanol / 13 h / 0 - 20 °C 5.1: thionyl chloride / dichloromethane / 2 h / 20 °C 6.1: N,N-dimethyl-formamide / 15 h / 20 °C 7.1: diisobutylaluminium hydride / toluene / 12 h / -78 °C 7.2: 2.5 h / -78 - 0 °C 8.1: triethylamine / dichloromethane / 0.33 h / 0 - 20 °C 9.1: 10 wt% Pd(OH)2 on carbon; hydrogen / ethanol / 16 h 10.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / chloroform; tert-butyl alcohol / 0.08 h View Scheme |
tolterodine tartrate
(R)-(+)-tolterodine
Conditions | Yield |
---|---|
With sodium carbonate; sodium hydroxide In dichloromethane; water at 0 - 20℃; for 0.583333h; | |
With sodium hydrogencarbonate In ethyl acetate | 6.9 g |
tolterodine tartrate
(R)-[4-benzyloxy-3-(3-diisopropylamino-1-phenyl-propyl)-phenyl]-methanal
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydroxide; sodium carbonate / water; dichloromethane / 0.58 h / 0 - 20 °C 2: potassium carbonate / N,N-dimethyl-formamide / 13 h / 20 °C 3: ammonium cerium (IV) nitrate / water; acetonitrile / 4.08 h / 0 - 20 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: sodium hydroxide; sodium carbonate / dichloromethane; water / 0.58 h / 0 - 20 °C 1.2: 13 h / 20 °C 2.1: ammonium cerium (IV) nitrate / acetonitrile; water / 4 h / 0 - 20 °C View Scheme |
tolterodine tartrate
{4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]phenyl}methanol
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium hydroxide; sodium carbonate / water; dichloromethane / 0.58 h / 0 - 20 °C 2: potassium carbonate / N,N-dimethyl-formamide / 13 h / 20 °C 3: ammonium cerium (IV) nitrate / water; acetonitrile / 4.08 h / 0 - 20 °C 4: sodium tetrahydroborate; methanol / 13 h / 0 - 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: sodium hydroxide; sodium carbonate / dichloromethane; water / 0.58 h / 0 - 20 °C 1.2: 13 h / 20 °C 2.1: ammonium cerium (IV) nitrate / acetonitrile; water / 4 h / 0 - 20 °C 3.1: sodium tetrahydroborate / methanol / 13 h / 0 - 20 °C View Scheme |
tolterodine tartrate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: sodium hydroxide; sodium carbonate / water; dichloromethane / 0.58 h / 0 - 20 °C 2: potassium carbonate / N,N-dimethyl-formamide / 13 h / 20 °C 3: ammonium cerium (IV) nitrate / water; acetonitrile / 4.08 h / 0 - 20 °C 4: sodium tetrahydroborate; methanol / 13 h / 0 - 20 °C 5: thionyl chloride / dichloromethane / 2 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: sodium hydroxide; sodium carbonate / dichloromethane; water / 0.58 h / 0 - 20 °C 1.2: 13 h / 20 °C 2.1: ammonium cerium (IV) nitrate / acetonitrile; water / 4 h / 0 - 20 °C 3.1: sodium tetrahydroborate / methanol / 13 h / 0 - 20 °C 4.1: thionyl chloride / dichloromethane / 2 h / 20 °C View Scheme |
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