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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages of Tolterodine tartrate Cas 124937-52-6 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:Cool dry place Package:100g,1kg/foi

High quality Tolterodine tartrate Cas 124937-52-6 with favorable price

Cas:124937-52-6

Min.Order:100 Gram

Negotiable

Type:Trading Company

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

Factory Supply Tolterodine Tartrate CAS 124937-52-6

Cas:124937-52-6

Min.Order:1 Kilogram

FOB Price: $10.0

Type:Trading Company

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Tolterodine Tartrate

Cas:124937-52-6

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Tolterodine tartrate 124937-52-6 ISO Manufacturer

Cas:124937-52-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Tolterodine tartrate

Cas:124937-52-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Tolterodine tartrate

Cas:124937-52-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Tolterodine tartrate

Cas:124937-52-6

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 124937-52-6 with best quality

Cas:124937-52-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Tolterodine Tartrate

Cas:124937-52-6

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Tolterodine tartrate/ LIDE PHARMA- Factory supply / Best price

Cas:124937-52-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Product Name: Tolterodine tartrate CAS No.:124937-52-6 Molecular Formula:C22H31NO.C4H6O6 Grade Standard:Medicine Grade Purity:99%min Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package:25kg/drum Applicati

Tolterodine tartrate

Cas:124937-52-6

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White or off-white powder Storage:Store in sealed containers

Tolterodine Tartrate Urinary System Medications CAS 124937-52-6

Cas:124937-52-6

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:white-to-off-white crystalline powder Storage:Room temperature Package:25kg/drum Application:API Transportation:Express/Sea/Air Port:Any port in china

High Quality Supply Tolterodine Tartrate CAS:124937-52-6

Cas:124937-52-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Tolterodine tartrate 124937-52-6

Cas:124937-52-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Tolterodine tartrate manufacturer with low price

Cas:124937-52-6

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Competitive M receptor antagonist, Tolterodine tartrate CAS:124937-52-6

Cas:124937-52-6

Min.Order:1 Gram

FOB Price: $11.0 / 16.0

Type:Trading Company

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Tolterodine L-Tartrate

Cas:124937-52-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,

Tolterodine Tartrate CAS NO.: 124937-52-6

Cas:124937-52-6

Min.Order:20 Metric Ton

Negotiable

Type:Trading Company

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Product quality: Our company have high quality product , and also the product we have good manufacture . First of all, this product is of fine quality. Every finish should be checked by quality inspection system.And every one should be also tried

Tolterodine Tartrate CAS 124937-52-6

Cas:124937-52-6

Min.Order:1 Kilogram

FOB Price: $20.0 / 30.0

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Tolterodine tartrate

Cas:124937-52-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: Tolterodine tartrate Synonyms: 124937-52-6;Detrol LA;PNU-200583E;(±)-Tolterodine-d14 Tartrate;Tolterodine(Detrol);2-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-methylphenol(2R,3R)-2,3-dihydroxybutanedioate;Tolterodin

Tolterodine tartrate free sample available best quality

Cas:124937-52-6

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:off-white to white solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for Synthesis API and Research Transportation:As customer request Port:Qingda

Tolterodine Tartrate 124937-52-6

Cas:124937-52-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Tolterodine tartrate

Cas:124937-52-6

Min.Order:1 Kilogram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

inquiry

Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

High Purity Tolterodine Tartrate CAS 124937-52-6 with Fast Shipment

Cas:124937-52-6

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Tolterodine tartrate 124937-52-6

Cas:124937-52-6

Min.Order:100 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Tolterodine Tartrate

Cas:124937-52-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Tolterodine tartrate

Cas:124937-52-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

Tolterodine tartrate

Cas:124937-52-6

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

124937-52-6 Appearance:white powder Storage:room temperature Package:according to customers' requirements Application:Pharma intermediates Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or CNF ect...)or according to y

124937-52-6

Cas:124937-52-6

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

JINING XINHE CHEMICAL CO., LTD

Advantage 1: The product passed the professional production process and quality inspection, the purity is 99% +. 2: Highly qualified engineers to provide technical documents and service. 3: We could provide sample for your test. 4: High qualit

API Tolterodine tartrate

Cas:124937-52-6

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropylamine hydrochloride

N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropylamine hydrochloride

L-Tartaric acid
87-69-4

L-Tartaric acid

tolterodine tartrate
124937-52-6

tolterodine tartrate

Conditions
ConditionsYield
Stage #1: N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropylamine hydrochloride With sodium carbonate; sodium hydroxide In dichloromethane; water at 20℃; for 1h;
Stage #2: L-Tartaric acid In methanol; acetone for 1h; Reflux;
88%
Stage #1: N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropylamine hydrochloride With sodium carbonate; sodium hydroxide In dichloromethane; water at 0 - 20℃; for 1h;
Stage #2: L-Tartaric acid In methanol; acetone at 0℃; for 2h; Reflux;
30%
Stage #1: N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropylamine hydrochloride With sodium hydroxide In dichloromethane; water at 25 - 35℃; for 0.0833333 - 0.166667h;
Stage #2: L-Tartaric acid In methanol; dichloromethane; water; acetonitrile at 0 - 35℃; for 6.58333 - 13h; Heating / reflux;
Stage #1: N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropylamine hydrochloride With sodium carbonate; sodium hydroxide In dichloromethane; water
Stage #2: L-Tartaric acid In ethanol at 0 - 70℃;
n/a
3-(2-hydroxy-5-methylphenyl)-N,N-diisopropyl-3-phenylpropan-1-aminium bromide
837376-36-0

3-(2-hydroxy-5-methylphenyl)-N,N-diisopropyl-3-phenylpropan-1-aminium bromide

L-Tartaric acid
87-69-4

L-Tartaric acid

tolterodine tartrate
124937-52-6

tolterodine tartrate

Conditions
ConditionsYield
Stage #1: 3-(2-hydroxy-5-methylphenyl)-N,N-diisopropyl-3-phenylpropan-1-aminium bromide With sodium hydroxide In dichloromethane; water
Stage #2: L-Tartaric acid In ethanol at 60 - 85℃;
39%
(+/-)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propanamide
897314-72-6

(+/-)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propanamide

L-Tartaric acid
87-69-4

L-Tartaric acid

tolterodine tartrate
124937-52-6

tolterodine tartrate

Conditions
ConditionsYield
Stage #1: (+/-)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propanamide With sodium bis(2-methoxyethoxy)aluminium dihydride In toluene at 5 - 40℃; for 6h; Cooling with ice;
Stage #2: L-Tartaric acid In ethanol at 0 - 70℃; Reflux;
37%
N,N-diiso-propyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine

N,N-diiso-propyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine

L-Tartaric acid
87-69-4

L-Tartaric acid

tolterodine tartrate
124937-52-6

tolterodine tartrate

Conditions
ConditionsYield
In ethanol at 60 - 85℃;18%
In ethanol at 0 - 80℃; for 5h; Resolution of racemate;
In methanol; acetone; toluene at 20 - 60℃; for 12.5h; Resolution of racemate;n/a
In ethanol Product distribution / selectivity;
L-Tartaric acid
87-69-4

L-Tartaric acid

tolterodine tartrate
124937-52-6

tolterodine tartrate

Conditions
ConditionsYield
Stage #1: tolterodine hydrobromide With potassium hydroxide In water; ethyl acetate for 0.25 - 0.5h;
Stage #2: L-Tartaric acid In ethanol; ethyl acetate at 0℃; for 5 - 17h; Product distribution / selectivity;

L-Tartaric acid
87-69-4

L-Tartaric acid

tolterodine tartrate
124937-52-6

tolterodine tartrate

Conditions
ConditionsYield
In ethanol at 25 - 30℃; for 0.5h; Product distribution / selectivity; Resolution of racemate;
(+/-)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propanamide
897314-72-6

(+/-)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propanamide

L-Tartaric acid
87-69-4

L-Tartaric acid

A

(S)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine L-hydrogen tartrate
873551-03-2

(S)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine L-hydrogen tartrate

B

tolterodine tartrate
124937-52-6

tolterodine tartrate

Conditions
ConditionsYield
Stage #1: (+/-)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propanamide With sodium bis(2-methoxyethoxy)aluminium dihydride In toluene at 70℃; for 6.08333h; Inert atmosphere; Cooling with ice;
Stage #2: With sodium hydroxide In acetone; toluene at 40 - 60℃; for 0.25h;
Stage #3: L-Tartaric acid In methanol at 0℃; Product distribution / selectivity; Reflux;
A n/a
B n/a
Stage #1: (+/-)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propanamide With sodium bis(2-methoxyethoxy)aluminium dihydride In toluene at 5 - 40℃; for 6h; Cooling with ice;
Stage #2: L-Tartaric acid In isopropyl alcohol at 20 - 75℃; for 3.5h; Product distribution / selectivity;
A n/a
B n/a
N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropylamine hydrochloride

N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropylamine hydrochloride

L-Tartaric acid
87-69-4

L-Tartaric acid

A

(S)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine L-hydrogen tartrate
873551-03-2

(S)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine L-hydrogen tartrate

B

tolterodine tartrate
124937-52-6

tolterodine tartrate

Conditions
ConditionsYield
In ethanol at 0 - 70℃;A n/a
B n/a
N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propylamine L-tartrate
1043911-42-7

N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propylamine L-tartrate

L-Tartaric acid
87-69-4

L-Tartaric acid

tolterodine tartrate
124937-52-6

tolterodine tartrate

Conditions
ConditionsYield
In water; isopropyl alcohol at 20 - 65℃; Purification / work up; Resolution of racemate; Reflux;n/a
N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-2-propenamide

N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-2-propenamide

A

(S)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine L-hydrogen tartrate
873551-03-2

(S)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine L-hydrogen tartrate

B

tolterodine tartrate
124937-52-6

tolterodine tartrate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydrogen / 5%-palladium/activated carbon / water; 2-methyltetrahydrofuran / 2.5 h / 55 °C / 750.08 Torr
2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 6 h / 5 - 40 °C / Cooling with ice
2.2: 3.5 h / 20 - 75 °C
View Scheme
Multi-step reaction with 3 steps
1.1: hydrogen / 5%-palladium/activated carbon / water; 2-methyltetrahydrofuran / 2.5 h / 55 °C / 750.08 Torr
2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 6 h / 5 - 40 °C / Cooling with ice
2.2: 20 - 60 °C
3.1: ethanol / 0 - 70 °C
View Scheme
N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-2-propenamide

N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-2-propenamide

tolterodine tartrate
124937-52-6

tolterodine tartrate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydrogen / 5%-palladium/activated carbon / water; 2-methyltetrahydrofuran / 2.5 h / 55 °C / 750.08 Torr
2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 6 h / 5 - 40 °C / Cooling with ice
2.2: 0 - 70 °C / Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: hydrogen / 5%-palladium/activated carbon / water; 2-methyltetrahydrofuran / 2.5 h / 55 °C / 750.08 Torr
2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 6 h / 5 - 40 °C / Cooling with ice
2.2: 20 - 60 °C
3.1: sodium hydroxide; sodium carbonate / dichloromethane; water
3.2: 0 - 70 °C
View Scheme
(+/-)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propanamide
897314-72-6

(+/-)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propanamide

A

(S)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine L-hydrogen tartrate
873551-03-2

(S)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine L-hydrogen tartrate

B

tolterodine tartrate
124937-52-6

tolterodine tartrate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 6 h / 5 - 40 °C / Cooling with ice
1.2: 20 - 60 °C
2.1: ethanol / 0 - 70 °C
View Scheme
C23H24O4S

C23H24O4S

tolterodine tartrate
124937-52-6

tolterodine tartrate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: triethylamine / water / 2 h / 0 °C
2.1: acetonitrile / 12 h / Reflux
3.1: sodium hydroxide / methanol; water / 4 h / Reflux
3.2: 1 h / 20 °C
4.1: sodium hydroxide; sodium carbonate / dichloromethane; water / 1 h / 20 °C
4.2: 1 h / Reflux
View Scheme
1-phenyl-1,3-propanediol
4850-49-1

1-phenyl-1,3-propanediol

tolterodine tartrate
124937-52-6

tolterodine tartrate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: iron(III) chloride hexahydrate / dichloromethane / 24 h / Reflux
2.1: sodium hydroxide / dichloromethane; water / 1 h / 40 °C
3.1: triethylamine / water / 2 h / 0 °C
4.1: acetonitrile / 12 h / Reflux
5.1: sodium hydroxide / methanol; water / 4 h / Reflux
5.2: 1 h / 20 °C
6.1: sodium hydroxide; sodium carbonate / dichloromethane; water / 1 h / 20 °C
6.2: 1 h / Reflux
View Scheme
3-phenyl-3-(2'-hydroxy-5'-methyl)phenylpropanol-1
851789-43-0

3-phenyl-3-(2'-hydroxy-5'-methyl)phenylpropanol-1

tolterodine tartrate
124937-52-6

tolterodine tartrate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium hydroxide / dichloromethane; water / 1 h / 40 °C
2.1: triethylamine / water / 2 h / 0 °C
3.1: acetonitrile / 12 h / Reflux
4.1: sodium hydroxide / methanol; water / 4 h / Reflux
4.2: 1 h / 20 °C
5.1: sodium hydroxide; sodium carbonate / dichloromethane; water / 1 h / 20 °C
5.2: 1 h / Reflux
View Scheme
2-(3-(4-nitrobenzenesulfonyloxy)-1-phenylpropyl)-4-methylphenyl p-toluenesulfonate

2-(3-(4-nitrobenzenesulfonyloxy)-1-phenylpropyl)-4-methylphenyl p-toluenesulfonate

tolterodine tartrate
124937-52-6

tolterodine tartrate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: acetonitrile / 12 h / Reflux
2.1: sodium hydroxide / methanol; water / 4 h / Reflux
2.2: 1 h / 20 °C
3.1: sodium hydroxide; sodium carbonate / dichloromethane; water / 1 h / 20 °C
3.2: 1 h / Reflux
View Scheme
ethyl 3-oxo-3-phenylpropionate
94-02-0

ethyl 3-oxo-3-phenylpropionate

tolterodine tartrate
124937-52-6

tolterodine tartrate

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: sodium tetrahydroborate / methanol / 1 h / 20 °C
2.1: iron(III) chloride hexahydrate / dichloromethane / 24 h / Reflux
3.1: sodium hydroxide / dichloromethane; water / 1 h / 40 °C
4.1: triethylamine / water / 2 h / 0 °C
5.1: acetonitrile / 12 h / Reflux
6.1: sodium hydroxide / methanol; water / 4 h / Reflux
6.2: 1 h / 20 °C
7.1: sodium hydroxide; sodium carbonate / dichloromethane; water / 1 h / 20 °C
7.2: 1 h / Reflux
View Scheme
6-methylcoumarin
92-48-8

6-methylcoumarin

tolterodine tartrate
124937-52-6

tolterodine tartrate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: (R)-(6,6’-dimethoxybiphenyl-2,2’-diyl)bis[bis(3-fluoro-4-trifluoromethylphenyl)phosphine]; chlorobis(ethylene)rhodium(I) dimer; sodium hydrogencarbonate / toluene; water / 36 h / 25 °C / Schlenk technique; Inert atmosphere
2.1: citric acid; diisobutylaluminium hydride / toluene; hexane; water; ethyl acetate / -25 - 20 °C / Inert atmosphere
3.1: formic acid; Cp*IrCl(8-quinolinolate) / tetrahydrofuran / 20 h / 0 - 50 °C / Schlenk technique; Inert atmosphere
3.2: 4 h / 0 - 80 °C
View Scheme
phenylboronic acid
98-80-6

phenylboronic acid

tolterodine tartrate
124937-52-6

tolterodine tartrate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: (R)-(6,6’-dimethoxybiphenyl-2,2’-diyl)bis[bis(3-fluoro-4-trifluoromethylphenyl)phosphine]; chlorobis(ethylene)rhodium(I) dimer; sodium hydrogencarbonate / toluene; water / 36 h / 25 °C / Schlenk technique; Inert atmosphere
2.1: citric acid; diisobutylaluminium hydride / toluene; hexane; water; ethyl acetate / -25 - 20 °C / Inert atmosphere
3.1: formic acid; Cp*IrCl(8-quinolinolate) / tetrahydrofuran / 20 h / 0 - 50 °C / Schlenk technique; Inert atmosphere
3.2: 4 h / 0 - 80 °C
View Scheme
(R)-6-methyl-4-phenyl-3,4-dihydrochromen-2-one
827007-19-2

(R)-6-methyl-4-phenyl-3,4-dihydrochromen-2-one

tolterodine tartrate
124937-52-6

tolterodine tartrate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: citric acid; diisobutylaluminium hydride / toluene; hexane; water; ethyl acetate / -25 - 20 °C / Inert atmosphere
2.1: formic acid; Cp*IrCl(8-quinolinolate) / tetrahydrofuran / 20 h / 0 - 50 °C / Schlenk technique; Inert atmosphere
2.2: 4 h / 0 - 80 °C
View Scheme
(4R)-6-methyl-4-phenylchroman-2-ol
828933-86-4

(4R)-6-methyl-4-phenylchroman-2-ol

L-Tartaric acid
87-69-4

L-Tartaric acid

diisopropylamine
108-18-9

diisopropylamine

tolterodine tartrate
124937-52-6

tolterodine tartrate

Conditions
ConditionsYield
Stage #1: (4R)-6-methyl-4-phenylchroman-2-ol; diisopropylamine With formic acid; Cp*IrCl(8-quinolinolate) In tetrahydrofuran at 0 - 50℃; for 20h; Schlenk technique; Inert atmosphere;
Stage #2: L-Tartaric acid In ethanol at 0 - 80℃; for 4h;
940.7 mg
3-(2-benzyloxy-5-methylphenyl)-3-phenylpropanol
854306-68-6

3-(2-benzyloxy-5-methylphenyl)-3-phenylpropanol

tolterodine tartrate
124937-52-6

tolterodine tartrate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: triethylamine; dmap / dichloromethane / 2 h / 20 °C
2.1: acetonitrile / 16 h / Reflux
3.1: hydrogen; palladium on activated charcoal / methanol / 19 h
4.1: hydrogenchloride / methanol / 0.5 h / 0 °C
5.1: sodium hydroxide; sodium carbonate / dichloromethane; water / 1 h / 0 - 20 °C
5.2: 2 h / 0 °C / Reflux
View Scheme
C29H27NO6S

C29H27NO6S

tolterodine tartrate
124937-52-6

tolterodine tartrate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: acetonitrile / 16 h / Reflux
2.1: hydrogen; palladium on activated charcoal / methanol / 19 h
3.1: hydrogenchloride / methanol / 0.5 h / 0 °C
4.1: sodium hydroxide; sodium carbonate / dichloromethane; water / 1 h / 0 - 20 °C
4.2: 2 h / 0 °C / Reflux
View Scheme
N,N-diisopropyl-3-(2-benzyloxy-5-methylphenyl)-3-phenylpropylamine
389068-22-8

N,N-diisopropyl-3-(2-benzyloxy-5-methylphenyl)-3-phenylpropylamine

tolterodine tartrate
124937-52-6

tolterodine tartrate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: hydrogen; palladium on activated charcoal / methanol / 19 h
2.1: hydrogenchloride / methanol / 0.5 h / 0 °C
3.1: sodium hydroxide; sodium carbonate / dichloromethane; water / 1 h / 0 - 20 °C
3.2: 2 h / 0 °C / Reflux
View Scheme
N,N-diiso-propyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine
124936-74-9

N,N-diiso-propyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine

tolterodine tartrate
124937-52-6

tolterodine tartrate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydrogenchloride / methanol / 0.5 h / 0 °C
2.1: sodium hydroxide; sodium carbonate / dichloromethane; water / 1 h / 0 - 20 °C
2.2: 2 h / 0 °C / Reflux
View Scheme
6-methyl-4-phenyl-3,4-dihydrocoumarin
40546-94-9

6-methyl-4-phenyl-3,4-dihydrocoumarin

tolterodine tartrate
124937-52-6

tolterodine tartrate

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: potassium carbonate / acetone / 2 h / Reflux
1.2: 2 h / Reflux
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C
3.1: triethylamine; dmap / dichloromethane / 2 h / 20 °C
4.1: acetonitrile / 16 h / Reflux
5.1: hydrogen; palladium on activated charcoal / methanol / 19 h
6.1: hydrogenchloride / methanol / 0.5 h / 0 °C
7.1: sodium hydroxide; sodium carbonate / dichloromethane; water / 1 h / 0 - 20 °C
7.2: 2 h / 0 °C / Reflux
View Scheme
methyl 3-(2-benzyloxy-5-methylphenyl)-3-phenylpropionate
854306-67-5

methyl 3-(2-benzyloxy-5-methylphenyl)-3-phenylpropionate

tolterodine tartrate
124937-52-6

tolterodine tartrate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C
2.1: triethylamine; dmap / dichloromethane / 2 h / 20 °C
3.1: acetonitrile / 16 h / Reflux
4.1: hydrogen; palladium on activated charcoal / methanol / 19 h
5.1: hydrogenchloride / methanol / 0.5 h / 0 °C
6.1: sodium hydroxide; sodium carbonate / dichloromethane; water / 1 h / 0 - 20 °C
6.2: 2 h / 0 °C / Reflux
View Scheme
benzyl bromide
100-39-0

benzyl bromide

tolterodine tartrate
124937-52-6

tolterodine tartrate

(R)-3-(2-(benzyloxy)-5-methylphenyl)-N,N-diisopropyl-3-phenylpropan-1-amine
848768-06-9

(R)-3-(2-(benzyloxy)-5-methylphenyl)-N,N-diisopropyl-3-phenylpropan-1-amine

Conditions
ConditionsYield
Stage #1: tolterodine tartrate With sodium carbonate; sodium hydroxide In dichloromethane; water at 0 - 20℃; for 0.583333h;
Stage #2: benzyl bromide With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 13h;
100%
3,6-dichloro-2,5-dihydroxy-1,4-benzoquinone
87-88-7

3,6-dichloro-2,5-dihydroxy-1,4-benzoquinone

tolterodine tartrate
124937-52-6

tolterodine tartrate

C22H31NO*C4H6O6*C6H2Cl2O4

C22H31NO*C4H6O6*C6H2Cl2O4

Conditions
ConditionsYield
In acetonitrile at 25℃;
2,3-dicyano-5,6-dichloro-p-benzoquinone
84-58-2

2,3-dicyano-5,6-dichloro-p-benzoquinone

tolterodine tartrate
124937-52-6

tolterodine tartrate

tolterodine tartarate

tolterodine tartarate

Conditions
ConditionsYield
In acetonitrile at 25℃;
tolterodine tartrate
124937-52-6

tolterodine tartrate

(R)-3-(2-(benzyloxy)-5-methylphenyl)-N,N-diisopropyl-3-phenylpropan-1-amine
848768-06-9

(R)-3-(2-(benzyloxy)-5-methylphenyl)-N,N-diisopropyl-3-phenylpropan-1-amine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide; sodium carbonate / water; dichloromethane / 0.58 h / 0 - 20 °C
2: potassium carbonate / N,N-dimethyl-formamide / 13 h / 20 °C
View Scheme
tolterodine tartrate
124937-52-6

tolterodine tartrate

(R)-2-(4-(benzyloxy)-3-(3-(diisopropylamino)-1-phenylpropyl)phenyl)acetonitrile

(R)-2-(4-(benzyloxy)-3-(3-(diisopropylamino)-1-phenylpropyl)phenyl)acetonitrile

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: sodium hydroxide; sodium carbonate / water; dichloromethane / 0.58 h / 0 - 20 °C
2: potassium carbonate / N,N-dimethyl-formamide / 13 h / 20 °C
3: ammonium cerium (IV) nitrate / water; acetonitrile / 4.08 h / 0 - 20 °C
4: sodium tetrahydroborate; methanol / 13 h / 0 - 20 °C
5: thionyl chloride / dichloromethane / 2 h / 20 °C
6: N,N-dimethyl-formamide / 15 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: sodium hydroxide; sodium carbonate / dichloromethane; water / 0.58 h / 0 - 20 °C
1.2: 13 h / 20 °C
2.1: ammonium cerium (IV) nitrate / acetonitrile; water / 4 h / 0 - 20 °C
3.1: sodium tetrahydroborate / methanol / 13 h / 0 - 20 °C
4.1: thionyl chloride / dichloromethane / 2 h / 20 °C
5.1: N,N-dimethyl-formamide / 15 h / 20 °C
View Scheme
tolterodine tartrate
124937-52-6

tolterodine tartrate

(R)-benzyl 7-((4-(benzyloxy)-3-(3-(diisopropylamino)-1-phenylpropyl)phenethyl)amino)-7-oxoheptanoate

(R)-benzyl 7-((4-(benzyloxy)-3-(3-(diisopropylamino)-1-phenylpropyl)phenethyl)amino)-7-oxoheptanoate

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: sodium hydroxide; sodium carbonate / water; dichloromethane / 0.58 h / 0 - 20 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 13 h / 20 °C
3.1: ammonium cerium (IV) nitrate / water; acetonitrile / 4.08 h / 0 - 20 °C
4.1: sodium tetrahydroborate; methanol / 13 h / 0 - 20 °C
5.1: thionyl chloride / dichloromethane / 2 h / 20 °C
6.1: N,N-dimethyl-formamide / 15 h / 20 °C
7.1: diisobutylaluminium hydride / toluene / 12 h / -78 °C
7.2: 2.5 h / -78 - 0 °C
8.1: triethylamine / dichloromethane / 0.33 h / 0 - 20 °C
View Scheme
Multi-step reaction with 7 steps
1.1: sodium hydroxide; sodium carbonate / dichloromethane; water / 0.58 h / 0 - 20 °C
1.2: 13 h / 20 °C
2.1: ammonium cerium (IV) nitrate / acetonitrile; water / 4 h / 0 - 20 °C
3.1: sodium tetrahydroborate / methanol / 13 h / 0 - 20 °C
4.1: thionyl chloride / dichloromethane / 2 h / 20 °C
5.1: N,N-dimethyl-formamide / 15 h / 20 °C
6.1: diisobutylaluminium hydride / toluene / 12 h / -78 °C
6.2: 2.5 h / -78 - 0 °C
7.1: triethylamine / dichloromethane / 0.33 h / 0 - 20 °C
View Scheme
tolterodine tartrate
124937-52-6

tolterodine tartrate

(R)-7-((3-(3-(diisopropylamino)-1-phenylpropyl)-4-hydroxyphenethyl)amino)-7-oxoheptanoic acid

(R)-7-((3-(3-(diisopropylamino)-1-phenylpropyl)-4-hydroxyphenethyl)amino)-7-oxoheptanoic acid

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: sodium hydroxide; sodium carbonate / water; dichloromethane / 0.58 h / 0 - 20 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 13 h / 20 °C
3.1: ammonium cerium (IV) nitrate / water; acetonitrile / 4.08 h / 0 - 20 °C
4.1: sodium tetrahydroborate; methanol / 13 h / 0 - 20 °C
5.1: thionyl chloride / dichloromethane / 2 h / 20 °C
6.1: N,N-dimethyl-formamide / 15 h / 20 °C
7.1: diisobutylaluminium hydride / toluene / 12 h / -78 °C
7.2: 2.5 h / -78 - 0 °C
8.1: triethylamine / dichloromethane / 0.33 h / 0 - 20 °C
9.1: 10 wt% Pd(OH)2 on carbon; hydrogen / ethanol / 16 h
View Scheme
Multi-step reaction with 8 steps
1.1: sodium hydroxide; sodium carbonate / dichloromethane; water / 0.58 h / 0 - 20 °C
1.2: 13 h / 20 °C
2.1: ammonium cerium (IV) nitrate / acetonitrile; water / 4 h / 0 - 20 °C
3.1: sodium tetrahydroborate / methanol / 13 h / 0 - 20 °C
4.1: thionyl chloride / dichloromethane / 2 h / 20 °C
5.1: N,N-dimethyl-formamide / 15 h / 20 °C
6.1: diisobutylaluminium hydride / toluene / 12 h / -78 °C
6.2: 2.5 h / -78 - 0 °C
7.1: triethylamine / dichloromethane / 0.33 h / 0 - 20 °C
8.1: hydrogen; 10 wt% Pd(OH)2 on carbon / ethanol / 16 h
View Scheme
tolterodine tartrate
124937-52-6

tolterodine tartrate

C73H128N3O12P

C73H128N3O12P

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1.1: sodium hydroxide; sodium carbonate / water; dichloromethane / 0.58 h / 0 - 20 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 13 h / 20 °C
3.1: ammonium cerium (IV) nitrate / water; acetonitrile / 4.08 h / 0 - 20 °C
4.1: sodium tetrahydroborate; methanol / 13 h / 0 - 20 °C
5.1: thionyl chloride / dichloromethane / 2 h / 20 °C
6.1: N,N-dimethyl-formamide / 15 h / 20 °C
7.1: diisobutylaluminium hydride / toluene / 12 h / -78 °C
7.2: 2.5 h / -78 - 0 °C
8.1: triethylamine / dichloromethane / 0.33 h / 0 - 20 °C
9.1: 10 wt% Pd(OH)2 on carbon; hydrogen / ethanol / 16 h
10.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / chloroform; tert-butyl alcohol / 0.08 h
View Scheme
tolterodine tartrate
124937-52-6

tolterodine tartrate

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

Conditions
ConditionsYield
With sodium carbonate; sodium hydroxide In dichloromethane; water at 0 - 20℃; for 0.583333h;
With sodium hydrogencarbonate In ethyl acetate6.9 g
tolterodine tartrate
124937-52-6

tolterodine tartrate

(R)-[4-benzyloxy-3-(3-diisopropylamino-1-phenyl-propyl)-phenyl]-methanal
214601-54-4

(R)-[4-benzyloxy-3-(3-diisopropylamino-1-phenyl-propyl)-phenyl]-methanal

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide; sodium carbonate / water; dichloromethane / 0.58 h / 0 - 20 °C
2: potassium carbonate / N,N-dimethyl-formamide / 13 h / 20 °C
3: ammonium cerium (IV) nitrate / water; acetonitrile / 4.08 h / 0 - 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydroxide; sodium carbonate / dichloromethane; water / 0.58 h / 0 - 20 °C
1.2: 13 h / 20 °C
2.1: ammonium cerium (IV) nitrate / acetonitrile; water / 4 h / 0 - 20 °C
View Scheme
tolterodine tartrate
124937-52-6

tolterodine tartrate

{4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]phenyl}methanol
156755-37-2

{4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]phenyl}methanol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium hydroxide; sodium carbonate / water; dichloromethane / 0.58 h / 0 - 20 °C
2: potassium carbonate / N,N-dimethyl-formamide / 13 h / 20 °C
3: ammonium cerium (IV) nitrate / water; acetonitrile / 4.08 h / 0 - 20 °C
4: sodium tetrahydroborate; methanol / 13 h / 0 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydroxide; sodium carbonate / dichloromethane; water / 0.58 h / 0 - 20 °C
1.2: 13 h / 20 °C
2.1: ammonium cerium (IV) nitrate / acetonitrile; water / 4 h / 0 - 20 °C
3.1: sodium tetrahydroborate / methanol / 13 h / 0 - 20 °C
View Scheme
tolterodine tartrate
124937-52-6

tolterodine tartrate

C29H36ClNO

C29H36ClNO

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: sodium hydroxide; sodium carbonate / water; dichloromethane / 0.58 h / 0 - 20 °C
2: potassium carbonate / N,N-dimethyl-formamide / 13 h / 20 °C
3: ammonium cerium (IV) nitrate / water; acetonitrile / 4.08 h / 0 - 20 °C
4: sodium tetrahydroborate; methanol / 13 h / 0 - 20 °C
5: thionyl chloride / dichloromethane / 2 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: sodium hydroxide; sodium carbonate / dichloromethane; water / 0.58 h / 0 - 20 °C
1.2: 13 h / 20 °C
2.1: ammonium cerium (IV) nitrate / acetonitrile; water / 4 h / 0 - 20 °C
3.1: sodium tetrahydroborate / methanol / 13 h / 0 - 20 °C
4.1: thionyl chloride / dichloromethane / 2 h / 20 °C
View Scheme
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