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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to off-white powder Storage:cool dry place Package:25kg/drum Application:medicine raw material Transportatio

Manufacturer high quality Tolterodine Cas 124937-51-5 with good price

Cas:124937-51-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Tolterodine 124937-51-5 GMP Manufacturer

Cas:124937-51-5

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price in China. If you are looking for the product’s supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product specifica

Tolterodine

Cas:124937-51-5

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be sent

Tolterodine

Cas:124937-51-5

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 124937-51-5 with best quality

Cas:124937-51-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Tolterodine/ LIDE PHARMA- Factory supply / Best price

Cas:124937-51-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

Phenol,2-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-methyl-

Cas:124937-51-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Tolterodine CAS:124937-51-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate

Tolterodine CAS:124937-51-5

Cas:124937-51-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Phenol,2-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-methyl-

Cas:124937-51-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of hig

Tolterodine L-tartrate

Cas:124937-51-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

DETRUSITOL

Cas:124937-51-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Tolterodine

Cas:124937-51-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

Tolterodine

Cas:124937-51-5

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Tolterodine

Cas:124937-51-5

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Tolterodine

Cas:124937-51-5

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providing h

Factory Supply Tolterodine

Cas:124937-51-5

Min.Order:0

Negotiable

Type:Other

inquiry

Siwei Development Group Ltd.

Product name: Tolterodine CAS No.:124937-51-5 Molecule Formula:C22H31NO Molecule Weight:325.48 Purity: 99.0% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard TESTING ITEMS

High Quality Tolterodine in stock

Cas:124937-51-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Quality Manufacturer Tolterodine

Cas:124937-51-5

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Tolterodine

Cas:124937-51-5

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Tolterodine

Cas:124937-51-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:Active Pharmaceutical I

Tolterodine

Cas:124937-51-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

Tolterodine

Cas:124937-51-5

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

Tolterodine L-Tartrate

Cas:124937-51-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY:1) Specialized in pharmaceutical and healthcare industrial since 19872) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days.4) We have warehouse in USA with quickly shipment .5) We can do different t

99% up by HPLC Tolterodine 124937-51-5

Cas:124937-51-5

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

Tolterodine

Cas:124937-51-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

Tolterodine

Cas:124937-51-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

Tolterodine

Cas:124937-51-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Wuhan Circle Star Chem-medical Technology co.,Ltd.

1,we produce and sell good chemicals around the world.2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%.3,our staff consists of highly qualified in

Tolterodine

Cas:124937-51-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dawn Ray Pharmaceutical Co.,Ltd

Appearance: White or almost white crystalline powder Total impurity: ≤0.2% Assay :≥ 99.0% Appearance:White or almost white crystalline powder or crystals Storage:cool and dry Package:25kg/drum Application:A toadstool alkali receptor antagonis

Tolterodine

Cas:124937-51-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages? High purity, all above 98.5%, no impurities after dissolution? We will test each batch to ensure quality? OEM and private brand services designed for free? Various cap colors available? We can also provide MT1 peptide powder2.

Tolterodine

Cas:124937-51-5

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

(R)-3-(2-(benzyloxy)-5-methylphenyl)-N,N-diisopropyl-3-phenylpropan-1-amine
848768-06-9

(R)-3-(2-(benzyloxy)-5-methylphenyl)-N,N-diisopropyl-3-phenylpropan-1-amine

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In methanol at 20℃; for 24h;100%
With palladium on activated charcoal; hydrogen In methanol at 20℃; for 24h;100%
With hydrogen; palladium on activated charcoal In methanol at 20℃; under 760 Torr; for 12h;97%
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 1125.11 Torr; for 24h;94%
(R)-N,N-diisopropyl-3-[2-(benzyloxy)-5-methylphenyl]-3-phenylpropan-1-amine

(R)-N,N-diisopropyl-3-[2-(benzyloxy)-5-methylphenyl]-3-phenylpropan-1-amine

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

Conditions
ConditionsYield
With hydrogenchloride In isopropyl alcohol at 50℃; for 22h;98%
(4R)-6-methyl-4-phenylchroman-2-ol
828933-86-4

(4R)-6-methyl-4-phenylchroman-2-ol

diisopropylamine
108-18-9

diisopropylamine

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

Conditions
ConditionsYield
With sodium cyanoborohydride; acetic acid In methanol at 20℃; for 72h; Inert atmosphere;93%
With palladium 10% on activated carbon; hydrogen In methanol at 50℃; under 2585.81 Torr; for 12h; Autoclave;93%
With hydrogen; palladium on activated charcoal In methanol under 2585.74 Torr; for 12h; Heating;91%
(Z)-2-(3-(diisopropylamino)-1-phenylprop-1-enyl)-4-methylphenol
1275593-51-5

(Z)-2-(3-(diisopropylamino)-1-phenylprop-1-enyl)-4-methylphenol

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

Conditions
ConditionsYield
With 1,2-bis [(2S,5S)-2,5-diphenylphospholano]ethane 1,5-cyclooctadiene rhodium(I) tetrafluoroborate; hydrogen; lithium tert-butoxide In toluene at 20℃; under 2585.81 Torr; for 2h; Inert atmosphere; optical yield given as %ee; enantioselective reaction;89%
(R)-N,N-diisopropyl-3-(2-methoxy-5-methylphenyl)-3-phenylpropan-1-amine
518360-71-9

(R)-N,N-diisopropyl-3-(2-methoxy-5-methylphenyl)-3-phenylpropan-1-amine

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

Conditions
ConditionsYield
With hydrogen bromide; acetic acid87%
Stage #1: (R)-N,N-diisopropyl-3-(2-methoxy-5-methylphenyl)-3-phenylpropan-1-amine With boron tribromide In dichloromethane at -78 - 0℃;
Stage #2: With methanol In dichloromethane at -78 - 20℃; optical yield given as %ee;
diisopropyl-(3-phenyl-3-p-toluyloxypropyl)amine
906532-18-1

diisopropyl-(3-phenyl-3-p-toluyloxypropyl)amine

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

Conditions
ConditionsYield
Stage #1: diisopropyl-(3-phenyl-3-p-toluyloxypropyl)amine With sulfuric acid In water at 20℃; for 3h;
Stage #2: With sodium hydroxide In water for 0.5h; pH=9 - 10; Product distribution / selectivity;
82%
Stage #1: diisopropyl-(3-phenyl-3-p-toluyloxypropyl)amine at 20℃; for 3h;
Stage #2: With sodium hydroxide In water for 0.5h; pH=9 - 10; Product distribution / selectivity;
C29H37NO3S
851789-55-4

C29H37NO3S

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

Conditions
ConditionsYield
With sodium hydroxide In methanol for 4h; Heating;82%
p-cresol
106-44-5

p-cresol

3-(N,N-diisopropylamino)-1-phenylpropan-1-ol
906532-26-1

3-(N,N-diisopropylamino)-1-phenylpropan-1-ol

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

Conditions
ConditionsYield
Stage #1: p-cresol; 3-(N,N-diisopropylamino)-1-phenylpropan-1-ol With sulfuric acid In water at 40℃; for 3h;
Stage #2: With sodium hydroxide In water for 0.5h; pH=9 - 10; Product distribution / selectivity;
80%
(4R)-6-methyl-4-phenylchroman-2-ol
828933-86-4

(4R)-6-methyl-4-phenylchroman-2-ol

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

Conditions
ConditionsYield
With sodium cyanoborohydride; acetic acid; diisopropylamine In methanol at 20℃; for 72h;48%
(R)-3-(2-Benzyloxy-5-methyl-phenyl)-N,N-diisopropyl-3-phenyl-propionamide
215929-29-6

(R)-3-(2-Benzyloxy-5-methyl-phenyl)-N,N-diisopropyl-3-phenyl-propionamide

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

Conditions
ConditionsYield
With lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal 1) ether, rt, overnight; 2) MeOH, 1 atm, rt, overnight; Yield given. Multistep reaction;
Multi-step reaction with 2 steps
1: dimethylsulfide borane complex / tetrahydrofuran / 20 h / Inert atmosphere; Reflux
2: palladium 10% on activated carbon; hydrogen / methanol / 24 h / 20 °C / 1125.11 Torr
View Scheme
2-[3-[bis-(1-methylethyl)-amino]-1-phenylpropyl]-4-methylphenol tartrate

2-[3-[bis-(1-methylethyl)-amino]-1-phenylpropyl]-4-methylphenol tartrate

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

Conditions
ConditionsYield
Stage #1: 2-[3-[bis-(1-methylethyl)-amino]-1-phenylpropyl]-4-methylphenol tartrate In water; toluene pH=9.5;
Stage #2: With formic acid; tartaric acid In isopropyl alcohol Purification / work up;
6-methyl-4-phenylchromen-2-one
16299-22-2

6-methyl-4-phenylchromen-2-one

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: R,R-chiraphos; NaOH; H2 / [Rh(COD)Cl]2 / methanol / 24 h / 50 °C / 9000.9 Torr
1.2: pTsOH / toluene / 4 h / Heating
1.3: DIBALH / toluene / -25 °C
2.1: H2 / Pd/C / methanol / 12 h / 48 °C / 3800.26 Torr
View Scheme
Multi-step reaction with 2 steps
1: copper diacetate; diethoxymethylsilane; (R,R(Fc))-1-diphenylphosphino-2-(1-dicyclohexylphosphinoethyl)ferrocene / tetrahydrofuran; toluene; tert-butyl alcohol / 3 h / 20 °C / Inert atmosphere
2: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 72 h / 20 °C / Inert atmosphere
View Scheme
(R)-6-methyl-4-phenyl-3,4-dihydrochromen-2-one
827007-19-2

(R)-6-methyl-4-phenyl-3,4-dihydrochromen-2-one

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 95 percent / diisobutylaluminum hydride / toluene; hexane / 2.5 h / -25 - -20 °C
2: 91 percent / H2 / Pd/C / methanol / 12 h / 2585.74 Torr / Heating
View Scheme
Multi-step reaction with 4 steps
1.1: K2CO3 / 1 h / Heating
1.2: NaI / acetone / 36 h / 40 °C
1.3: 87 percent / LiAlH4 / tetrahydrofuran / 4 h / 0 °C
2.1: 83 percent / Et3N; DMAP / CH2Cl2 / 0 - 20 °C
3.1: 81 percent / K2CO3 / acetonitrile / 48 h / 60 °C
4.1: 97 percent / H2 / 10 percent Pd/C / methanol / 12 h / 20 °C / 760 Torr
View Scheme
Multi-step reaction with 2 steps
1: diisobutylaluminium hydride / toluene; hexane / -20 - 25 °C / Schlenk technique; Inert atmosphere
2: hydrogen; palladium 10% on activated carbon / methanol / 12 h / 50 °C / 2585.81 Torr / Autoclave
View Scheme
6-methylcoumarin
92-48-8

6-methylcoumarin

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 88 percent / Rh(acac)(C2H4)2; (R)-Segphos / dioxane; H2O / 8 h / 60 °C
2: 95 percent / diisobutylaluminum hydride / toluene; hexane / 2.5 h / -25 - -20 °C
3: 91 percent / H2 / Pd/C / methanol / 12 h / 2585.74 Torr / Heating
View Scheme
phenylboronic acid
98-80-6

phenylboronic acid

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 88 percent / Rh(acac)(C2H4)2; (R)-Segphos / dioxane; H2O / 8 h / 60 °C
2: 95 percent / diisobutylaluminum hydride / toluene; hexane / 2.5 h / -25 - -20 °C
3: 91 percent / H2 / Pd/C / methanol / 12 h / 2585.74 Torr / Heating
View Scheme
(R)-3-(2-(benzyloxy)-5-methylphenyl)-3-phenylpropan-1-ol
874651-73-7

(R)-3-(2-(benzyloxy)-5-methylphenyl)-3-phenylpropan-1-ol

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 83 percent / Et3N; DMAP / CH2Cl2 / 0 - 20 °C
2: 81 percent / K2CO3 / acetonitrile / 48 h / 60 °C
3: 97 percent / H2 / 10 percent Pd/C / methanol / 12 h / 20 °C / 760 Torr
View Scheme
Multi-step reaction with 3 steps
1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / Reflux
2: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 16 h / 20 °C
3: palladium on activated charcoal; hydrogen / methanol / 24 h / 20 °C
View Scheme
(R)-3-[2-(benzyloxy)-5-methylphenyl]-3-phenylpropyl 4-nitrobenzenesulfonate
874651-74-8

(R)-3-[2-(benzyloxy)-5-methylphenyl]-3-phenylpropyl 4-nitrobenzenesulfonate

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 81 percent / K2CO3 / acetonitrile / 48 h / 60 °C
2: 97 percent / H2 / 10 percent Pd/C / methanol / 12 h / 20 °C / 760 Torr
View Scheme
1-(benzyloxy)-2-bromo-4-methylbenzene
2830-53-7

1-(benzyloxy)-2-bromo-4-methylbenzene

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) Mg, 2.) CuBr*Me2S, Me2S / 1) THF, reflux, 15 min; 2) THF, -50 deg C, 3 min; 3) THF, 10 deg C, 2 h
2: 90 percent / LiOH, H2O2 / tetrahydrofuran; H2O
3: 1.) SOCl2 / 1) benzene, 50 deg C, 50 min; 2) ether, rt, 1.5 h
4: 1.) LiAlH4, 2.) H2 / 2.) Pd/C / 1) ether, rt, overnight; 2) MeOH, 1 atm, rt, overnight
View Scheme
(4R)-3-(3-phenyl-2-(E)-propenoyl)-4-phenyl-2-oxazolidinone
155835-37-3

(4R)-3-(3-phenyl-2-(E)-propenoyl)-4-phenyl-2-oxazolidinone

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) Mg, 2.) CuBr*Me2S, Me2S / 1) THF, reflux, 15 min; 2) THF, -50 deg C, 3 min; 3) THF, 10 deg C, 2 h
2: 90 percent / LiOH, H2O2 / tetrahydrofuran; H2O
3: 1.) SOCl2 / 1) benzene, 50 deg C, 50 min; 2) ether, rt, 1.5 h
4: 1.) LiAlH4, 2.) H2 / 2.) Pd/C / 1) ether, rt, overnight; 2) MeOH, 1 atm, rt, overnight
View Scheme
(R)-3-(2-(benzyloxy)-5-methylphenyl)-3-phenylpropanoic acid
215929-28-5

(R)-3-(2-(benzyloxy)-5-methylphenyl)-3-phenylpropanoic acid

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) SOCl2 / 1) benzene, 50 deg C, 50 min; 2) ether, rt, 1.5 h
2: 1.) LiAlH4, 2.) H2 / 2.) Pd/C / 1) ether, rt, overnight; 2) MeOH, 1 atm, rt, overnight
View Scheme
Multi-step reaction with 3 steps
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 24 h / 20 °C / Inert atmosphere
2: dimethylsulfide borane complex / tetrahydrofuran / 20 h / Inert atmosphere; Reflux
3: palladium 10% on activated carbon; hydrogen / methanol / 24 h / 20 °C / 1125.11 Torr
View Scheme
(R)-3-[(R)-3-(2-benzyloxy-5-methylphenyl)-3-phenylpropionyl]-4-phenyloxazolidin-2-one
215929-27-4

(R)-3-[(R)-3-(2-benzyloxy-5-methylphenyl)-3-phenylpropionyl]-4-phenyloxazolidin-2-one

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 90 percent / LiOH, H2O2 / tetrahydrofuran; H2O
2: 1.) SOCl2 / 1) benzene, 50 deg C, 50 min; 2) ether, rt, 1.5 h
3: 1.) LiAlH4, 2.) H2 / 2.) Pd/C / 1) ether, rt, overnight; 2) MeOH, 1 atm, rt, overnight
View Scheme
tolterodine tartrate

tolterodine tartrate

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

Conditions
ConditionsYield
With sodium hydroxide; sodium carbonate In water; toluene
N,N-diisopropyl-3-(2-methoxy-5-methylphenyl)-3-phenylpropan-1-amine
124935-88-2

N,N-diisopropyl-3-(2-methoxy-5-methylphenyl)-3-phenylpropan-1-amine

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

Conditions
ConditionsYield
With boron tribromide In dichloromethane at 0 - 5℃;
(+/-)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propanamide
897314-72-6

(+/-)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propanamide

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

Conditions
ConditionsYield
Stage #1: (+/-)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propanamide With lithium aluminium tetrahydride In diethyl ether for 96h; Heating / reflux;
Stage #2: With acetic acid In diethyl ether pH=5; Product distribution / selectivity;
6-methyl-4-phenyl-3,4-dihydrocoumarin
40546-94-9

6-methyl-4-phenyl-3,4-dihydrocoumarin

diisopropylamine
108-18-9

diisopropylamine

A

3-phenyl-3-(2'-hydroxy-5'-methyl)phenylpropanol-1
851789-43-0

3-phenyl-3-(2'-hydroxy-5'-methyl)phenylpropanol-1

B

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

C

2-hydroxy-6-methyl-4-phenyldihydrobenzopyran
209747-04-6

2-hydroxy-6-methyl-4-phenyldihydrobenzopyran

Conditions
ConditionsYield
Stage #1: 6-methyl-4-phenyl-3,4-dihydrocoumarin With diisobutylaluminium hydride In toluene at -25℃; for 5h;
Stage #2: With citric acid In water; ethyl acetate; toluene at 20℃;
Stage #3: diisopropylamine With hydrogen; 5%-palladium/activated carbon In methanol at 48℃; under 3800.26 Torr; for 12h;
1-(2-methoxy-5-methylphenyl)-1-phenyl-prop-2-ene-1-ol

1-(2-methoxy-5-methylphenyl)-1-phenyl-prop-2-ene-1-ol

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: thionyl chloride / tetrahydrofuran / 12 h / 22 °C
2: acetonitrile / 8 h / 60 °C
3: hydrogen bromide / water; acetic acid / 4 h / 112 °C
4: 1,2-bis [(2S,5S)-2,5-diphenylphospholano]ethane 1,5-cyclooctadiene rhodium(I) tetrafluoroborate; hydrogen; lithium tert-butoxide / toluene / 2 h / 20 °C / 2585.81 Torr / Inert atmosphere
View Scheme
C17H17ClO

C17H17ClO

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: acetonitrile / 8 h / 60 °C
2: hydrogen bromide / water; acetic acid / 4 h / 112 °C
3: 1,2-bis [(2S,5S)-2,5-diphenylphospholano]ethane 1,5-cyclooctadiene rhodium(I) tetrafluoroborate; hydrogen; lithium tert-butoxide / toluene / 2 h / 20 °C / 2585.81 Torr / Inert atmosphere
View Scheme
(2-methoxy-5-methylphenyl)phenylmethanone
4072-13-3

(2-methoxy-5-methylphenyl)phenylmethanone

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: tetrahydrofuran / 0 - 22 °C
2: thionyl chloride / tetrahydrofuran / 12 h / 22 °C
3: acetonitrile / 8 h / 60 °C
4: hydrogen bromide / water; acetic acid / 4 h / 112 °C
5: 1,2-bis [(2S,5S)-2,5-diphenylphospholano]ethane 1,5-cyclooctadiene rhodium(I) tetrafluoroborate; hydrogen; lithium tert-butoxide / toluene / 2 h / 20 °C / 2585.81 Torr / Inert atmosphere
View Scheme
2-hydroxy-5-methylbenzaldehyde
613-84-3

2-hydroxy-5-methylbenzaldehyde

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: potassium carbonate
2.1: Inert atmosphere; Schlenk technique
3.1: triethylamine / toluene / 2 h / 150 °C / Inert atmosphere
4.1: sec.-butyllithium / diethyl ether; cyclohexane; hexane / 1 h / -78 °C / Inert atmosphere; Schlenk technique
4.2: 2 h / -78 °C / Inert atmosphere; Schlenk technique
4.3: 16.08 h / -78 - 20 °C / Inert atmosphere; Schlenk technique
5.1: tetrabutyl ammonium fluoride; water / toluene / 1.5 h / 20 °C
6.1: osmium(VIII) oxide; sodium periodate
7.1: sodium tris(acetoxy)borohydride / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere
8.1: hydrogen bromide; acetic acid
View Scheme
Multi-step reaction with 4 steps
1.1: triphenylphosphine; lithium hydroxide monohydrate; lithium chloride / water / Reflux
2.1: calcium carbonate; palladium diacetate / methanol / 4 h / 60 °C
2.2: 20 °C
3.1: copper diacetate; diethoxymethylsilane; (R,R(Fc))-1-diphenylphosphino-2-(1-dicyclohexylphosphinoethyl)ferrocene / tetrahydrofuran; toluene; tert-butyl alcohol / 3 h / 20 °C / Inert atmosphere
4.1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 72 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1: triphenylphosphine; lithium hydroxide monohydrate; lithium chloride / water / Reflux
2: calcium carbonate; palladium diacetate / methanol / 60 °C
3: copper diacetate; diethoxymethylsilane; (R,R(Fc))-1-diphenylphosphino-2-(1-dicyclohexylphosphinoethyl)ferrocene / tetrahydrofuran; toluene; tert-butyl alcohol / 3 h / 20 °C / Inert atmosphere
4: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 72 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 9 steps
1.1: toluene / 1.5 h / 80 °C
2.1: potassium carbonate / acetone / 20 °C
2.2: 3 h / Reflux
3.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 0.5 h
4.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C
4.2: 0.75 h / -78 - 0 °C
5.1: palladium diacetate; [2,2]bipyridinyl / methanol; water / 16 h / 80 °C / Schlenk technique; Sealed tube
6.1: lithium borohydride / diethyl ether / 3 h / 0 - 20 °C / Inert atmosphere
7.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / Reflux
8.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 16 h / 20 °C
9.1: palladium on activated charcoal; hydrogen / methanol / 24 h / 20 °C
View Scheme
Multi-step reaction with 6 steps
1.1: 18-crown-6 ether; potassium carbonate / acetone / 0.5 h / 20 °C
1.2: 3 h / Reflux
2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere
2.2: 2 h / 0 - 20 °C / Inert atmosphere
3.1: potassium hydroxide; C47H55O7P; chlorobis(ethylene)rhodium(I) dimer / water; 1,4-dioxane / 24 h / 20 °C / Inert atmosphere
3.2: 3 h / Reflux
4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 24 h / 20 °C / Inert atmosphere
5.1: dimethylsulfide borane complex / tetrahydrofuran / 20 h / Inert atmosphere; Reflux
6.1: palladium 10% on activated carbon; hydrogen / methanol / 24 h / 20 °C / 1125.11 Torr
View Scheme
isobutyryl chloride
79-30-1

isobutyryl chloride

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

2-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-methylphenyl 2-methylpropanoate
895137-81-2

2-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-methylphenyl 2-methylpropanoate

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran; water at 20℃; for 1h; Inert atmosphere;96%
With sodium hydroxide In tetrahydrofuran; water at 20℃; Inert atmosphere;96%
Stage #1: isobutyryl chloride; (R)-(+)-tolterodine In dichloromethane at -10 - 0℃;
Stage #2: With sodium hydrogencarbonate In dichloromethane; water for 0.25h;
Hippuric Acid
495-69-2

Hippuric Acid

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

tolterodine hippurate
1182264-69-2

tolterodine hippurate

Conditions
ConditionsYield
In acetone at 25℃; Inert atmosphere;92.3%
In acetone at 25℃;92.3%
benzenesulfonic acid
98-11-3

benzenesulfonic acid

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

tolterodine benzene sulfonate
1182264-73-8

tolterodine benzene sulfonate

Conditions
ConditionsYield
In acetone at 25℃; Inert atmosphere;89.9%
In acetone at 25℃;89.9%
(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

Pamoic acid
130-85-8

Pamoic acid

tolterodine palmoate

tolterodine palmoate

Conditions
ConditionsYield
In water at 20℃; for 4h; Temperature;87.27%
(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

1-hydroxy-2-naphthoic acid
86-48-6

1-hydroxy-2-naphthoic acid

tolterodine 1-hydroxy-2-naphthate
615255-99-7

tolterodine 1-hydroxy-2-naphthate

Conditions
ConditionsYield
In acetone at 25℃; Inert atmosphere;84.1%
In acetone at 25℃;84.1%
toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

tolterodine p-toluene sulfonate
1182264-77-2

tolterodine p-toluene sulfonate

Conditions
ConditionsYield
In acetone at 25℃; Inert atmosphere;83%
In acetone at 25℃;83%
(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

tolterodine L-pyroglutamate
1182264-79-4

tolterodine L-pyroglutamate

Conditions
ConditionsYield
In acetone at 25℃;82.3%
In acetone at 25℃; for 1.16667h;82.3%
naphthalene-1,5-disulfonate
81-04-9

naphthalene-1,5-disulfonate

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

tolterodine hemi naphthalene-1,5-disulfonate

tolterodine hemi naphthalene-1,5-disulfonate

Conditions
ConditionsYield
In acetone at 25℃; for 1.16667h;78.4%
In acetone at 25℃; for 1.16667h;78.4%
Adipic acid
124-04-9

Adipic acid

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

tolterodine hemiadipate

tolterodine hemiadipate

Conditions
ConditionsYield
In acetone at 25℃; for 1.16667h;74.3%
Adipic acid
124-04-9

Adipic acid

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

tolterodine hemiadipate

tolterodine hemiadipate

Conditions
ConditionsYield
In acetone at 25℃; for 1.16667h;74.3%
benzoic acid
65-85-0

benzoic acid

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

tolterodine benzoate
615255-00-0

tolterodine benzoate

Conditions
ConditionsYield
In acetone at 25℃; for 1.16667h;73.1%
In acetone at 25℃; for 1.16667h;73.1%
glycolic Acid
79-14-1

glycolic Acid

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

(R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-methylphenol 2-hydroxyacetate
1182264-86-3

(R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-methylphenol 2-hydroxyacetate

Conditions
ConditionsYield
In acetone at 25℃; for 1.16667h;69.2%
In acetone at 25℃; for 1.16667h;69.2%
2,5-dihydroxybenzoic acid.
490-79-9

2,5-dihydroxybenzoic acid.

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

tolterodine gentisate
1182264-71-6

tolterodine gentisate

Conditions
ConditionsYield
In acetone at 25℃; Inert atmosphere;42.5%
In acetone at 25℃;42.5%
(2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid
97950-17-9

(2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

tolterodine retinoate

tolterodine retinoate

Conditions
ConditionsYield
In acetone at 25℃;22.4%
all-trans-retinoic-acid
302-79-4

all-trans-retinoic-acid

(R)-(+)-tolterodine
124937-51-5

(R)-(+)-tolterodine

tolterodine retinoate
1182264-88-5

tolterodine retinoate

Conditions
ConditionsYield
In ethanol; acetone at 25℃;22.4%

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