As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryDocetaxel Side Chain Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate CAS:32981-85-4 HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten yea
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inquiryProduct Name: Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate Synonyms: PACLITAXEL SIDE CHAIN 4;PACLITAXEL SIDE CHAIN NO 4;C-13 SIDE CHAIN FOR PACLITAXEL II;(2R,3S)-1-Benzoyl-2-Hydroxy-3-Aminophenylpionic Acid Ester;METHYL (2R,3S)-3-B
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inquiryMethyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate CAS:32981-85-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, s
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquiryProduct name: Methyl (2R,3S)-N-Benzoylphenylisoserinate CAS No.:32981-85-4 Molecule Formula:C17H17NO4 Molecule Weight:299.32 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TEST
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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inquiryHubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medicine)
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inquiryLocated in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h
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inquirySuperior quality, moderate price & quick delivery. Appearance:white powder Storage:stored in a cool, dry and ventilated place to provent sun and rain Package:25kg/drum, or as per your request. Application:Used as Pharmaceutical Intermediate
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inquiryLower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe
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inquirymethyl (2R,3S)-3-benzoylamino-2-benzyloxy-3-phenylpropanethioate
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
Conditions | Yield |
---|---|
With palladium on activated charcoal; hydrogen In methanol under 4654.46 Torr; | 100% |
With hydrogen; 1% Pd/C In methanol under 4654.46 Torr; | 100% |
With hydrogenchloride; hydrogen; palladium on activated charcoal In ethanol at 60℃; for 1h; | 78% |
With hydrogen; palladium on activated charcoal In ethanol at 60℃; | 78% |
Methyl (2R,3S)-(+)-2-hydroxy-3-azido-3-phenyl-propionate
benzoyl chloride
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
Conditions | Yield |
---|---|
Stage #1: Methyl (2R,3S)-(+)-2-hydroxy-3-azido-3-phenyl-propionate; benzoyl chloride With dmap; triethylamine In ethyl acetate at 20℃; for 4h; Stage #2: With hydrogen; palladium on activated charcoal In methanol; ethyl acetate for 48h; Further stages.; | 92% |
Stage #1: Methyl (2R,3S)-(+)-2-hydroxy-3-azido-3-phenyl-propionate; benzoyl chloride With dmap; triethylamine In methanol; ethyl acetate at 20℃; for 7h; Stage #2: With hydrogen; palladium on activated carbon In methanol; ethyl acetate for 48h; | 92% |
Stage #1: Methyl (2R,3S)-(+)-2-hydroxy-3-azido-3-phenyl-propionate; benzoyl chloride; dmap In methanol; ethyl acetate at 20℃; for 7h; Stage #2: With hydrogen; palladium 10% on activated carbon In methanol; ethyl acetate for 48h; | 88% |
methyl (2R,3S)-2-acetoxy-3-phenyl-3-benzoylaminopropanoate
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
Conditions | Yield |
---|---|
With sodium methylate In methanol at 20℃; for 1h; | 92% |
(4S,5R)-2,4-diphenyl-2-oxazoline-5-carboxylic acid methyl ester
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
Conditions | Yield |
---|---|
With hydrogenchloride In methanol for 2h; Heating; | 90% |
With hydrogenchloride In methanol for 5h; Heating; | 85% |
With hydrogenchloride In methanol for 5h; Heating; | 85% |
diazomethane
(2R,3S)-N-benzoyl-3-phenylisoserine
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
Conditions | Yield |
---|---|
In tetrahydrofuran; diethyl ether | 90% |
In methanol; diethyl ether |
(2R,3S)-(+)-methyl 3-azido-2-benzoly-3-phenylpropionate
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In methanol | 88% |
With hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal | 76% |
With hydrogen; palladium on activated charcoal In methanol under 2585.7 Torr; for 4h; | 74% |
With hydrogen; palladium on activated charcoal In methanol at 20℃; under 760 Torr; for 48h; | 71% |
With hydrogen; palladium on activated charcoal 1.) CH3OH, 15 h, 2.) CH3OH, RT, 72 h; Yield given. Multistep reaction; |
methanol
benzoyl chloride
(2R,3S)-3-acetylamino-2-hydroxy-3-phenylpropanoic acid isopropyl ester
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
Conditions | Yield |
---|---|
Stage #1: methanol; (2R,3S)-3-acetylamino-2-hydroxy-3-phenylpropanoic acid isopropyl ester With hydrogenchloride for 20h; Heating; Stage #2: benzoyl chloride With triethylamine In dichloromethane at 0 - 20℃; | 88% |
methanol
benzoyl chloride
(2R,3S)-3-phenylisoserine hydrochloride
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
Conditions | Yield |
---|---|
Stage #1: benzoyl chloride; (2R,3S)-3-phenylisoserine hydrochloride With sodium hydroxide In water at 20℃; for 1h; pH=9 - 12; Stage #2: methanol Concentration; | 85.6% |
methanol
benzyl chloride
(2R,3S)-3-acetylamino-2-hydroxy-3-phenylpropanoic acid isopropyl ester
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
Conditions | Yield |
---|---|
Stage #1: methanol; (2R,3S)-3-acetylamino-2-hydroxy-3-phenylpropanoic acid isopropyl ester With hydrogenchloride for 20h; Addition; Heating; Stage #2: benzyl chloride With triethylamine In dichloromethane at 0 - 20℃; for 2h; Substitution; Further stages.; | 85% |
methyl (2S,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
Conditions | Yield |
---|---|
With thionyl chloride In dichloromethane for 5h; Inert atmosphere; Reflux; | 85% |
Multi-step reaction with 2 steps 1.1: SOCl2 / CH2Cl2 / Heating 2.1: HCl / H2O; methanol / Heating 2.2: NaHCO3 / H2O; methanol / 50 °C View Scheme | |
Multi-step reaction with 2 steps 1: 90 percent / DEAD; PPh3 / benzene / 20 h / 20 °C 2: 90 percent / 1N aq. HCl / methanol / 2 h / Heating View Scheme | |
Multi-step reaction with 2 steps 1: 77 percent / Ph3P, diethylazodicarboxylate / tetrahydrofuran / Ambient temperature 2: 1.) aq. HCl, 2.) aq. NaHCO3 / 1) CH3OH, room temperature, 1.5 h; 2) room temperature, 16 h View Scheme | |
Multi-step reaction with 2 steps 1: 1) SOCl2 / 1) CHCl3, 45 deg C, 5 h, 2) CHCl3, reflux, 48 h 2: 80 percent / 1N HCl / methanol / 2 h / Heating View Scheme |
methanol
S-Ethyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanethioate
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
Conditions | Yield |
---|---|
With silver trifluoroacetate Ambient temperature; | 84% |
With silver trifluoroacetate at 20℃; for 1h; Methylation; | 84% |
taxol
A
10-deacetylbaccatin III
B
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
C
10-deacetyl-7-epi-baccatin III
Conditions | Yield |
---|---|
With lithium iodide In methanol for 10h; Ambient temperature; | A 58% B 82% C 40% |
With lithium iodide In methanol for 10h; Ambient temperature; | A 58% B 82% C 40% |
7-epipaclitaxel
A
7-epi-baccatin III
B
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
C
10-deacetyl-7-epi-baccatin III
Conditions | Yield |
---|---|
With lithium iodide In methanol for 14h; Ambient temperature; | A 56% B 78% C 17% |
(2aR,4S,4aS,6R,9S,11S,12S,12bS)-6,12b-bis(acetyloxy)-9-({(2R,3S)-3-(benzoylamino)-3-phenyl-2-[(triethylsilyl)oxy]propanoyl}oxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9, 10,11,12,12a,12bdodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate
A
10-deacetylbaccatin III
B
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
C
10-deacetyl-7-epi-baccatin III
Conditions | Yield |
---|---|
With lithium iodide In methanol Ambient temperature; 2 weeks; | A 22% B 71% C 34% |
methanol
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
Conditions | Yield |
---|---|
With caesium carbonate In tetrahydrofuran at 20℃; for 1.5h; | 51% |
methanol
A
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
B
methyl (2S,3R)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
Conditions | Yield |
---|---|
In methanol Title compound not separated from byproducts; | |
With sodium methylate Title compound not separated from byproducts; |
methanol
A
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
B
3-Benzoylamino-2-hydroxy-3-phenyl-propionic acid methyl ester
C
methyl (2S,3R)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
Conditions | Yield |
---|---|
In methanol Title compound not separated from byproducts; | |
With sodium methylate Title compound not separated from byproducts; |
methanol
A
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
B
3-Benzoylamino-2-hydroxy-3-phenyl-propionic acid methyl ester
C
methyl (2S,3R)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
Conditions | Yield |
---|---|
In methanol Title compound not separated from byproducts; | |
With sodium methylate Title compound not separated from byproducts; |
methanol
A
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
B
3-Benzoylamino-2-hydroxy-3-phenyl-propionic acid methyl ester
Conditions | Yield |
---|---|
In methanol Title compound not separated from byproducts; | |
With sodium methylate |
methanol
A
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
B
3-Benzoylamino-2-hydroxy-3-phenyl-propionic acid methyl ester
C
methyl (2S,3R)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
Conditions | Yield |
---|---|
With sodium methylate Title compound not separated from byproducts; |
sodium methylate
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
Conditions | Yield |
---|---|
In methanol at 25℃; for 1h; | 79 mg |
benzoyl chloride
(2R,3S)-3-phenylisoserine methyl ester
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
Conditions | Yield |
---|---|
Yield given; | |
With sodium hydrogencarbonate In ethyl acetate | |
With sodium hydrogencarbonate In tetrahydrofuran; water at 0℃; for 2h; | 0.123 g |
With triethylamine | |
In dichloromethane at 20℃; for 5h; Time; Cooling with ice; | 267 g |
benzoyl chloride
methyl (2R,3S)-2-hydroxy-3-phenyl-3-<(S)-1-methylbenzylamino>propanoate
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
Conditions | Yield |
---|---|
With sodium hydroxide; hydrogen; palladium on activated charcoal 1.) MeOH, room temp., 30 h, 2.) THF, water, 0 deg C, 30 min; Yield given. Multistep reaction; |
A
benzoic acid methyl ester
B
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
Conditions | Yield |
---|---|
With hydrogenchloride In methanol Ambient temperature; |
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
Conditions | Yield |
---|---|
With ammonium hydroxide In methanol Ambient temperature; | |
With alkaline solution |
(R)-3-benzamido-3-phenylpropanoic acid methyl ester
A
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
B
methyl (2S,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
Conditions | Yield |
---|---|
With (+)-(2S,8aS)-(camphorylsulfonyl)oxaziridine; lithium chloride; lithium diisopropyl amide 1) -42 deg C, 2) -100 to -78 deg C; Yield given. Multistep reaction. Yields of byproduct given; | |
With MoO5*pyridine*HMPA; potassium hexamethylsilazane 1.) toluene, THF, -78 deg C to -25 deg C; 2.) toluene, THF, -60 deg C, 3 h; Yield given. Multistep reaction. Yields of byproduct given; |
A
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
B
(2R,3R)-(-)-2-hydroxy-3-(benzoylamino)-3-phenylpropanoic acid methyl ester
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In methanol | |
With hydrogen; palladium on activated charcoal In methanol Title compound not separated from byproducts; |
(2R,3S)-3-Benzoylamino-3-phenyl-2-trimethylsilanyloxy-propionic acid methyl ester
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
Conditions | Yield |
---|---|
With potassium fluoride In water |
syn-(+/-)-2-hydroxy-3-(benzoylamino)-3-phenylpropanoic acid methyl ester
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
methanol
taxol
A
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
B
baccatin III
C
7-epipaclitaxel
Conditions | Yield |
---|---|
at 58 - 116℃; Thermodynamic data; apparent activation energy Ea, other solvents, temperatures; |
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
(2-trimethylethylsilylethoxy)methyl chloride
(2R,3S)-N-benzoyl-O-<<2-(trimethylsilyl)ethoxy>methyl>-3-phenylisoserine methyl ester
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane for 40h; | 96% |
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
methanesulfonyl chloride
(2R,3S)-3-benzoylamino-2-methanesulfonyloxy-3-phenylpropanoic acid methyl ester
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at 0 - 20℃; | 93% |
With triethylamine In tetrahydrofuran at 0 - 20℃; for 1.5h; Mesylation; | 86% |
p-Anisaldehyde dimethyl acetal
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
Methyl (2R,4S,5R)-3-benzoyl-2-(p-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylate
Conditions | Yield |
---|---|
With pyridinium p-toluenesulfonate In cyclohexane; toluene | 91% |
1-methoxy-4-(methoxymethyl)benzene
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
Methyl (2R,4S,5R)-3-benzoyl-2-(p-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylate
Conditions | Yield |
---|---|
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In acetonitrile Heating; | 90% |
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In acetonitrile at 60℃; | 69% |
2-Methoxypropene
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
Methyl (4S,5R)-3-benzoyl-2,2-dimethyl-4-phenyl-1,3-oxazolidine-5-carboxylate
Conditions | Yield |
---|---|
With pyridinium p-toluenesulfonate In toluene at 85℃; | 89% |
With pyridinium p-toluenesulfonate In toluene at 80℃; for 10h; Etherification; Cyclization; | 89% |
With toluene-4-sulfonic acid at 80℃; |
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
(4S,5S)-2,4-diphenyl-2-oxazoline-5-carboxylic acid methyl ester
Conditions | Yield |
---|---|
With dmap; trifluoromethylsulfonic anhydride In dichloromethane at -30℃; for 1h; | 85% |
With dmap; trifluoromethylsulfonic anhydride In dichloromethane at -30℃; for 1h; Cyclization; Dehydration; | 84% |
With dmap; sulfuryl dichloride In dichloromethane at 0℃; Cyclization; | 65% |
Multi-step reaction with 2 steps 1: 93 percent / Et3N / tetrahydrofuran / 0 - 20 °C 2: DBU / CHCl3 / 2 h / Heating View Scheme | |
Multi-step reaction with 2 steps 1: 86 percent / Et3N / tetrahydrofuran / 1.5 h / 0 - 20 °C 2: DBU / CHCl3 / 2 h / Heating View Scheme |
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
chloromethyl methyl ether
(2R,3S)-N-benzoyl-O-(methoxymethyl)-3-phenylisoserine methyl ester
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane for 40h; | 82% |
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
(2R,3S)-N-benzoyl-3-phenylisoserine
Conditions | Yield |
---|---|
With potassium carbonate In methanol at 23℃; for 12h; | 80% |
p-Anisaldehyde dimethyl acetal
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
Methyl (2S,4S,5R)-3-benzoyl-2-(p-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylate
Conditions | Yield |
---|---|
With camphor-10-sulfonic acid In toluene | 79% |
p-Anisaldehyde dimethyl acetal
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
A
Methyl (2S,4S,5R)-3-benzoyl-2-(p-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylate
B
Methyl (2R,4S,5R)-3-benzoyl-2-(p-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylate
Conditions | Yield |
---|---|
With camphor-10-sulfonic acid In toluene at 130℃; Cycloaddition; | A 79% B 18% |
Benzyloxymethyl chloride
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
(2R,3S)-N-benzoyl-O-<(benzyloxy)methyl>-3-phenylisoserine methyl ester
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane for 40h; | 75% |
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
1,4-dimethoxybezene
Methyl (2R,4S,5R)-3-benzoyl-2-(p-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylate
Conditions | Yield |
---|---|
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In acetonitrile at 70℃; for 0.116667h; Substitution; Cyclization; | 75% |
p-Anisaldehyde dimethyl acetal
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
Conditions | Yield |
---|---|
Stage #1: p-Anisaldehyde dimethyl acetal; methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate With pyridinium p-toluenesulfonate In toluene for 6h; Inert atmosphere; Reflux; Stage #2: With methanol; sodium hydroxide In tetrahydrofuran at 0 - 25℃; for 3h; | 75% |
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
A
(4S,5R)-2,4-diphenyl-2-oxazoline-5-carboxylic acid methyl ester
B
3-N-benzoyl-4-phenyl-(4S,5R)-2-oxo-1,2,3-oxathiazolidine methyl ester
C
3-N-benzoyl-4-phenyl-(4S,5R)-2-oxo-1,2,3-oxathiazolidine methyl ester
Conditions | Yield |
---|---|
With thionyl chloride; triethylamine In benzene at 0 - 5℃; for 0.25h; Cyclization; | A 3% B 68% C 14% |
2,4-dimethoxybenzaldehyde dimethylacetal
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
Conditions | Yield |
---|---|
With pyridinium p-toluenesulfonate In tetrahydrofuran at 100℃; for 1.5h; Condensation; Title compound not separated from byproducts; | A 64% B n/a |
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