Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:132201-32-2
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:132201-32-2
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inquiryProduct description: Product name ((2R,3S)-3-Phenylisoserine hydrochloride CAS number 132201-32-2 Assay ≥99% Appearance White powder Capacity 100mt/year Application Pharmace
Cas:132201-32-2
Min.Order:100 Gram
FOB Price: $12.0
Type:Lab/Research institutions
inquiryUnique advantages of (2R,3S)-3-Phenylisoserine hydrochloride Cas 132201-32-2 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:Cool dry place Package
Cas:132201-32-2
Min.Order:1 Kilogram
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inquiryOur advantage: 1: High quality and Competitive price 2: Quality control, GC&HPLC&NMR or as your requested 3: Packing as your requested, and double check before shipment 4: Prompt shipment with professional documents 5: Excellent after-
Cas:132201-32-2
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:132201-32-2
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryproduct name: (2R,3S)-3-Phenylisoserine hydrochloride Synonyms: (2R,3S)-3-Amino-2-hydroxy-3-phenyl-propanoic acid hydrochloride;(2r,3s)-3-phenylisoserine hydrochloride;(2R,3S)-3-PHENYLISOSERINE HCl;(2R,3S)-3-phenylisoserine.HCl;(2R,3S)
Cas:132201-32-2
Min.Order:1 Gram
FOB Price: $8900.0
Type:Lab/Research institutions
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:132201-32-2
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FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:132201-32-2
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
Cas:132201-32-2
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inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquirystocks High quality Low price Appearance:White Storage:Preserve In Well-Closed, Light-Resistant and Tight Containers. Store In Cool & Dry Place Package:1g,5g,10g...1kg,5kg...more Application:API Transportation:shipping,land,air Port:Shanghai
Cas:132201-32-2
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:132201-32-2
Min.Order:10 Gram
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inquiryProduct name:(2R,3S)-3-Phenylisoserine Hydrochloride CAS No.:132201-32-2 Molecule Formula:C9H12ClNO3 Molecule Weight:217.65 Purity: 98.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard
Cas:132201-32-2
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:132201-32-2
Min.Order:1 Gram
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inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
Cas:132201-32-2
Min.Order:1 Milligram
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Type:Trading Company
inquiryHubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medicine)
Cas:132201-32-2
Min.Order:10 Milligram
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Type:Lab/Research institutions
inquiryLocated in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h
Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea
SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in
Cas:132201-32-2
Min.Order:0 Metric Ton
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inquirySuperior quality, moderate price & quick delivery. Appearance:white crystalline powder Storage:stored in a cool, dry and ventilated place to provent sun and rain Package:25kg/drum, or as per your request. Application:Used as Pharmaceutical
Cas:132201-32-2
Min.Order:1 Kilogram
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Type:Trading Company
inquiryHangzhou ZeErRui Chemical Co., Ltd. is a leading company that is focused on developing and producing high-quality flavor ingredients used for foods, pharmaceutic, cosmetics, and daily-use goods. Our goal is to produce flavor ingredients through scien
Cas:132201-32-2
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryLower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe
Cas:132201-32-2
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inquiryhighest purity most favorable priceAppearance:solid or liquid Storage:room temperature under 25℃ Package:drum or bag Application:for pharmaceutical Transportation:by sea and air
R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air
Cas:132201-32-2
Min.Order:0
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Type:Manufacturers
inquiryJinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands
Cas:132201-32-2
Min.Order:100 Gram
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Type:Lab/Research institutions
inquiryhigh quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea
Cas:132201-32-2
Min.Order:0
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Type:Manufacturers
inquiry(3R,4S)-3-hydroxy-4-phenylazetidin-2-one
(2R,3S)-3-phenylisoserine hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride for 12h; Heating; | 100% |
With hydrogenchloride at 25℃; for 3h; |
3-Triisopropylsilyloxy-4-phenylazetidin-2-one
(2R,3S)-3-phenylisoserine hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride at 25℃; for 3h; | 100% |
Multi-step reaction with 2 steps 1: 81 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.42 h / Ambient temperature 2: 6N hydrochloric acid / 3 h / 25 °C View Scheme |
(2R,3S)-3-Amino-2-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propionic acid isopropyl ester
(2R,3S)-3-phenylisoserine hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride Heating; | 100% |
(3R,4S)-3-triisopropylsilyloxy-4-phenylazetidin-2-one
(2R,3S)-3-phenylisoserine hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride at 25℃; for 5h; | 98% |
Multi-step reaction with 2 steps 1: 97 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / Ambient temperature 2: 100 percent / 6 N HCl / 12 h / Heating View Scheme |
(2R,3S)-3-phenylisoserine hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride; water for 5h; Reflux; | 95% |
methyl (2R,3S)-2,3-dihydroxy-3-phenylpropanoate
(2R,3S)-3-phenylisoserine hydrochloride
Conditions | Yield |
---|---|
Stage #1: methyl (2R,3S)-2,3-dihydroxy-3-phenylpropanoate With sulfuric acid; acetonitrile at -10 - 20℃; Stage #2: With hydrogenchloride Heating; | 86% |
Multi-step reaction with 5 steps 1: p-TsOH / CH2Cl2 / 5 h / Ambient temperature 2: AcBr / CH2Cl2 / 2 h / -15 °C 3: NaN3 / dimethylformamide / 50 °C 4: H2 / 10percent Pd/C / methanol / 48 h / 760 Torr / Ambient temperature 5: 10percent aq. HCl / 2 h / Heating View Scheme |
Methyl N-acetyl-3-phenylisoserine
(2R,3S)-3-phenylisoserine hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride for 2h; Heating; |
(2R,3S)-3-acetylamino-2-hydroxy-3-phenylpropanoic acid isopropyl ester
(2R,3S)-3-phenylisoserine hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride at 100℃; for 4h; Yield given; | |
With hydrogenchloride In water for 4h; Heating; |
(2R,3S)-2,3-dihydroxy-3-phenyl-propionic acid
A
(2R,3S)-3-phenylisoserine hydrochloride
Conditions | Yield |
---|---|
Stage #1: (2R,3S)-2,3-dihydroxy-3-phenyl-propionic acid With sulfuric acid; acetonitrile at -10 - 20℃; for 2h; Stage #2: With hydrogenchloride for 2h; Heating; |
(E)-isopropyl cinnamate
(2R,3S)-3-phenylisoserine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 81 percent / K2OsO2(OH)4; (DHQ)2-PHAL; LiOH 2: HCl / H2O / 4 h / Heating View Scheme | |
Multi-step reaction with 2 steps 1: 81 percent / (DHQ)2PHAL, aq. LiOH, K22(OH)4> / 2-methyl-propan-2-ol / 20 h / 4 °C 2: 10percent aq. HCl / 4 h / 100 °C View Scheme |
(E)-N-benzylidene-2-hydroxyaniline
(2R,3S)-3-phenylisoserine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: (S)-6,6'-dibromo-1,1'-bi-2-naphthol-1,2-dimethylimidazole - Zr(IV) complex / toluene / -78 °C 2: K2CO3 3: cerium ammonium nitrate / methanol 4: 100 percent / 10percent aq. HCl / Heating View Scheme | |
Multi-step reaction with 4 steps 1: (R)-6,6'-dibromo-1,1'-bi-2-naphthol-1,2-dimethylimidazole - Zr(IV) complex / toluene / 20 h / -78 °C 2: K2CO3 3: cerium ammonium nitrate / methanol 4: 100 percent / 10percent aq. HCl / Heating View Scheme |
(2R,3S)-2-(tert-Butyl-dimethyl-silanyloxy)-3-(2-methoxy-phenylamino)-3-phenyl-propionic acid isopropyl ester
(2R,3S)-3-phenylisoserine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: cerium ammonium nitrate / methanol 2: 100 percent / 10percent aq. HCl / Heating View Scheme |
isopropyl 2-tert-butyldimethylsiloxy-3-(2-hydroxyphenyl)amino-3-phenylpropionate
(2R,3S)-3-phenylisoserine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: K2CO3 2: cerium ammonium nitrate / methanol 3: 100 percent / 10percent aq. HCl / Heating View Scheme |
Methyl cinnamate
(2R,3S)-3-phenylisoserine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 71 percent / (DHQ)2PHAL, NMO, K2OsO2(OH)4 / H2O; 2-methyl-propan-2-ol / 23 h / Ambient temperature 2: p-TsOH / CH2Cl2 / 5 h / Ambient temperature 3: AcBr / CH2Cl2 / 2 h / -15 °C 4: NaN3 / dimethylformamide / 50 °C 5: H2 / 10percent Pd/C / methanol / 48 h / 760 Torr / Ambient temperature 6: 10percent aq. HCl / 2 h / Heating View Scheme |
methyl 2-acetoxy-3-azido-3-phenylpropanoate
(2R,3S)-3-phenylisoserine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: H2 / 10percent Pd/C / methanol / 48 h / 760 Torr / Ambient temperature 2: 10percent aq. HCl / 2 h / Heating View Scheme |
methyl (2R,3S)-2-acetoxy-3-bromo-3-phenylpropionate
(2R,3S)-3-phenylisoserine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: NaN3 / dimethylformamide / 50 °C 2: H2 / 10percent Pd/C / methanol / 48 h / 760 Torr / Ambient temperature 3: 10percent aq. HCl / 2 h / Heating View Scheme |
(4R,5S)-2-Methoxy-2-methyl-5-phenyl-[1,3]dioxolane-4-carboxylic acid methyl ester
(2R,3S)-3-phenylisoserine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: AcBr / CH2Cl2 / 2 h / -15 °C 2: NaN3 / dimethylformamide / 50 °C 3: H2 / 10percent Pd/C / methanol / 48 h / 760 Torr / Ambient temperature 4: 10percent aq. HCl / 2 h / Heating View Scheme |
N-benzylidene-1,1,1-trimethylsilanamine
(2R,3S)-3-phenylisoserine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1. diisopropylamine, n-butyllithium / 1. THF, 2 h; 2. THF a.) -78 deg C, 4 h, b.) r.t. 2: 81 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.42 h / Ambient temperature 3: 6N hydrochloric acid / 3 h / 25 °C View Scheme | |
Multi-step reaction with 2 steps 1: 1. diisopropylamine, n-butyllithium / 1. THF, 2 h; 2. THF a.) -78 deg C, 4 h, b.) r.t. 2: 100 percent / 6N hydrochloric acid / 3 h / 25 °C View Scheme | |
Multi-step reaction with 3 steps 1: 1. diisopropylamine, n-butyllithium / 1. THF, 2 h; 2. THF a.) -78 deg C, 4 h, b.) r.t. 2: 81 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.42 h / Ambient temperature 3: 6N hydrochloric acid / 3 h / 25 °C View Scheme | |
Multi-step reaction with 2 steps 1: 1. diisopropylamine, n-butyllithium / 1. THF, 2 h; 2. THF a.) -78 deg C, 4 h, b.) r.t. 2: 100 percent / 6N hydrochloric acid / 3 h / 25 °C View Scheme |
benzaldehyde
(2R,3S)-3-phenylisoserine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1. hexamethyldisilazane, n-BuLi / 1. THF, hexane, reflux, 3 h; 2. reflux, 2 h 2: 1. diisopropylamine, n-butyllithium / 1. THF, 2 h; 2. THF a.) -78 deg C, 4 h, b.) r.t. 3: 81 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.42 h / Ambient temperature 4: 6N hydrochloric acid / 3 h / 25 °C View Scheme | |
Multi-step reaction with 3 steps 1: 1. hexamethyldisilazane, n-BuLi / 1. THF, hexane, reflux, 3 h; 2. reflux, 2 h 2: 1. diisopropylamine, n-butyllithium / 1. THF, 2 h; 2. THF a.) -78 deg C, 4 h, b.) r.t. 3: 100 percent / 6N hydrochloric acid / 3 h / 25 °C View Scheme | |
Multi-step reaction with 4 steps 1: 1. hexamethyldisilazane, n-BuLi / 1. THF, hexane, reflux, 3 h; 2. reflux, 2 h 2: 1. diisopropylamine, n-butyllithium / 1. THF, 2 h; 2. THF a.) -78 deg C, 4 h, b.) r.t. 3: 81 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.42 h / Ambient temperature 4: 6N hydrochloric acid / 3 h / 25 °C View Scheme | |
Multi-step reaction with 3 steps 1: 1. hexamethyldisilazane, n-BuLi / 1. THF, hexane, reflux, 3 h; 2. reflux, 2 h 2: 1. diisopropylamine, n-butyllithium / 1. THF, 2 h; 2. THF a.) -78 deg C, 4 h, b.) r.t. 3: 100 percent / 6N hydrochloric acid / 3 h / 25 °C View Scheme |
[4-(benzylideneamino)phenyl]methanol
(2R,3S)-3-phenylisoserine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) LDA / 2.) THF, -95 deg C to -78 deg C 2: cerium ammonium nitrate / tetrahydrofuran 3: 98 percent / 6N hydrochloric acid / 5 h / 25 °C View Scheme |
1-(4-Methoxyphenyl)-3-triisopropylsilyloxy-4-phenyl-2-azetidinone
(2R,3S)-3-phenylisoserine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: cerium ammonium nitrate / tetrahydrofuran 2: 98 percent / 6N hydrochloric acid / 5 h / 25 °C View Scheme |
(E)-N-benzylidene-1,1,1-trimethylsilanamine
(2R,3S)-3-phenylisoserine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1) LDA / 2a) THF, -78 deg C, 4 h, 2b) rt, overnight 2: 97 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / Ambient temperature 3: 100 percent / 6 N HCl / 12 h / Heating View Scheme |
(2R,3S)-3-amino-2-hydroxy-3-phenylpropionic acid ethyl ester
(2R,3S)-3-phenylisoserine hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride; water Heating; |
(2R,3S)-3-phenylisoserine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Burkholderia cepacia lipase / di-isopropyl ether / 0.08 h / 50 °C / Resolution of racemate; Enzymatic reaction 2: hydrogenchloride; water / 5 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: Burkholderia cepacia lipase / toluene / 0.08 h / 50 °C / Resolution of racemate; Enzymatic reaction 2: hydrogenchloride; water / 5 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: Burkholderia cepacia lipase / di-isopropyl ether / 0.5 h / 25 °C / Enzymatic reaction 2: hydrogenchloride; water / 5 h / Reflux View Scheme |
(2R,3S)-3-phenylisoserine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: Sonication 2: Burkholderia cepacia lipase / di-isopropyl ether / 0.08 h / 50 °C / Resolution of racemate; Enzymatic reaction 3: hydrogenchloride; water / 5 h / Reflux View Scheme | |
Multi-step reaction with 3 steps 1: Sonication 2: Burkholderia cepacia lipase / toluene / 0.08 h / 50 °C / Resolution of racemate; Enzymatic reaction 3: hydrogenchloride; water / 5 h / Reflux View Scheme | |
Multi-step reaction with 3 steps 1: Sonication 2: Burkholderia cepacia lipase / di-isopropyl ether / 0.5 h / 25 °C / Enzymatic reaction 3: hydrogenchloride; water / 5 h / Reflux View Scheme |
3-Phenylpropenol
(2R,3S)-3-phenylisoserine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: D-(-)-diisopropyl tartrate; titanium(IV)isopropoxide / dichloromethane / Molecular sieve 2: sulfuric acid / 8 h / 20 - 25 °C 3: dipyridine chromium(VI) oxide / dichloromethane / 10 °C 4: hydrogenchloride / water / 100 - 110 °C View Scheme |
(2S,3S)-2,3-epoxy-3-phenyl-1-propanol
(2R,3S)-3-phenylisoserine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sulfuric acid / 8 h / 20 - 25 °C 2: dipyridine chromium(VI) oxide / dichloromethane / 10 °C 3: hydrogenchloride / water / 100 - 110 °C View Scheme |
(2R,3S)-3-phenylisoserine hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In water at 100 - 110℃; |
methanol
(2R,3S)-3-phenylisoserine hydrochloride
Conditions | Yield |
---|---|
With thionyl chloride at 0℃; for 3h; | 100% |
With thionyl chloride at 0℃; | 100% |
di-tert-butyl dicarbonate
(2R,3S)-3-phenylisoserine hydrochloride
RPR 130523
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In water; acetone | 89% |
With triethylamine In tetrahydrofuran; water at 0 - 20℃; | |
With sodium hydroxide In tetrahydrofuran |
methanol
benzoyl chloride
(2R,3S)-3-phenylisoserine hydrochloride
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate
Conditions | Yield |
---|---|
Stage #1: benzoyl chloride; (2R,3S)-3-phenylisoserine hydrochloride With sodium hydroxide In water at 20℃; for 1h; pH=9 - 12; Stage #2: methanol Concentration; | 85.6% |
benzoyl chloride
(2R,3S)-3-phenylisoserine hydrochloride
(2R,3S)-N-benzoyl-3-phenylisoserine
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In dichloromethane; water for 16h; Ambient temperature; | 72% |
With sodium hydrogencarbonate In dichloromethane; water | 70% |
With sodium hydroxide for 3h; Ambient temperature; Yield given; |
methanol
di-tert-butyl dicarbonate
(2R,3S)-3-phenylisoserine hydrochloride
methyl (2R,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-3-phenylpropionate
Conditions | Yield |
---|---|
Stage #1: di-tert-butyl dicarbonate; (2R,3S)-3-phenylisoserine hydrochloride With sodium hydroxide In tetrahydrofuran; water at 20 - 40℃; for 4h; Stage #2: methanol | 60% |
(2R,3S)-3-phenylisoserine hydrochloride
orthobenzoic acid trimethyl ester
(4S,5R)-2,4-diphenyl-2-oxazoline-5-carboxylic acid methyl ester
Conditions | Yield |
---|---|
In toluene for 8h; Heating; | 41% |
toluene-4-sulfonic acid
(2R,3S)-3-phenylisoserine hydrochloride
benzyl alcohol
Conditions | Yield |
---|---|
In benzene for 10h; Heating; | 1600 mg |
succinimidyl 2,2,2-trichloroethyl carbonate
(2R,3S)-3-phenylisoserine hydrochloride
Conditions | Yield |
---|---|
With sodium hydroxide; sodium hydrogencarbonate In 1,4-dioxane at 20℃; for 1h; |
(2R,3S)-3-phenylisoserine hydrochloride
benzyl chloroformate
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In diethyl ether at 0 - 20℃; | |
With sodium hydroxide In 1,4-dioxane at 0℃; for 3h; |
methanol
(2R,3S)-3-phenylisoserine hydrochloride
(2R,3S)-3-phenylisoserine methyl ester
Conditions | Yield |
---|---|
With thionyl chloride at 20℃; | |
With thionyl chloride at 20℃; for 6h; Time; Cooling with ice; |
(2R,3S)-3-phenylisoserine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: SOCl2 / 20 °C 2: aq. NaHCO3 / CH2Cl2 / 3 h / 20 °C 3: 469 mg / pyridinium p-toluenesulfonate / toluene / Heating 4: aq. KOH / methanol / 2 h / 20 °C View Scheme |
(2R,3S)-3-phenylisoserine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: SOCl2 / 20 °C 2: aq. NaHCO3 / CH2Cl2 / 3 h / 20 °C 3: 469 mg / pyridinium p-toluenesulfonate / toluene / Heating View Scheme |
(2R,3S)-3-phenylisoserine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: SOCl2 / 20 °C 2.1: aq. NaHCO3 / CH2Cl2 / 3 h / 20 °C 3.1: 469 mg / pyridinium p-toluenesulfonate / toluene / Heating 4.1: aq. KOH / methanol / 2 h / 20 °C 5.1: DMAP; DCC / CH2Cl2 / 2 h / 20 °C 5.2: 80 percent / p-toluenesulfonic acid / methanol / 5 h / 20 °C 6.1: 84 percent / pyridine; DMAP / CH2Cl2 / 20 °C 7.1: H2 / Pd/C / ethyl acetate / 8 h / 20 °C View Scheme |
(2R,3S)-3-phenylisoserine hydrochloride
13-(3'-N-benzyloxycarbonylphenylisoserine)-10-deacetyl-7,10-dibenzyloxycarbonylbaccatin III
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: SOCl2 / 20 °C 2.1: aq. NaHCO3 / CH2Cl2 / 3 h / 20 °C 3.1: 469 mg / pyridinium p-toluenesulfonate / toluene / Heating 4.1: aq. KOH / methanol / 2 h / 20 °C 5.1: DMAP; DCC / CH2Cl2 / 2 h / 20 °C 5.2: 80 percent / p-toluenesulfonic acid / methanol / 5 h / 20 °C View Scheme |
(2R,3S)-3-phenylisoserine hydrochloride
13-(3'-N-benzyloxycarbonyl-2'-tert-butoxycarbonylphenylisoserine)-10-deacetyl-7,10-dibenzyloxycarbonylbaccatin III
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: SOCl2 / 20 °C 2.1: aq. NaHCO3 / CH2Cl2 / 3 h / 20 °C 3.1: 469 mg / pyridinium p-toluenesulfonate / toluene / Heating 4.1: aq. KOH / methanol / 2 h / 20 °C 5.1: DMAP; DCC / CH2Cl2 / 2 h / 20 °C 5.2: 80 percent / p-toluenesulfonic acid / methanol / 5 h / 20 °C 6.1: 84 percent / pyridine; DMAP / CH2Cl2 / 20 °C View Scheme |
(2R,3S)-3-phenylisoserine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: SOCl2 / 20 °C 2.1: aq. NaHCO3 / CH2Cl2 / 3 h / 20 °C 3.1: 469 mg / pyridinium p-toluenesulfonate / toluene / Heating 4.1: aq. KOH / methanol / 2 h / 20 °C 5.1: DMAP; DCC / CH2Cl2 / 2 h / 20 °C 5.2: p-toluenesulfonic acid / methanol / 5 h / 20 °C View Scheme |
(2R,3S)-3-phenylisoserine hydrochloride
(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-3-amino-2-hydroxy-3-phenylpropanoyl)oxy)-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: SOCl2 / 20 °C 2.1: aq. NaHCO3 / CH2Cl2 / 3 h / 20 °C 3.1: 469 mg / pyridinium p-toluenesulfonate / toluene / Heating 4.1: aq. KOH / methanol / 2 h / 20 °C 5.1: DMAP; DCC / CH2Cl2 / 2 h / 20 °C 5.2: 80 percent / p-toluenesulfonic acid / methanol / 5 h / 20 °C 6.1: H2 / Pd/C / ethyl acetate / 8 h / 20 °C View Scheme |
(2R,3S)-3-phenylisoserine hydrochloride
(-)-(2R,3S)-methyl 3-(benzyloxycarbonylamino)-2-hydroxy-3-phenylpropanoate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: SOCl2 / 20 °C 2: aq. NaHCO3 / CH2Cl2 / 3 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: 100 percent / SOCl2 / 0 °C 2: NaHCO3 View Scheme | |
Multi-step reaction with 2 steps 1: 100 percent / SOCl2 / 3 h / 0 °C 2: 86 percent / NaHCO3 / CH2Cl2 / 2 h View Scheme | |
Multi-step reaction with 2 steps 1: sodium hydroxide / 1,4-dioxane / 3 h / 0 °C 2: N,N-dimethyl-formamide; thionyl chloride / 12 h / -78 - 20 °C View Scheme |
(2R,3S)-3-phenylisoserine hydrochloride
(4S,5R)-2,4-diphenyl-4,5-dihydrooxazole-5-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: NaOH / H2O View Scheme | |
Multi-step reaction with 2 steps 1: 41 percent / toluene / 8 h / Heating 2: 86 percent / NaOH / methanol; H2O / 20 °C View Scheme |
(2R,3S)-3-phenylisoserine hydrochloride
(4S,5R)-2,4-Diphenyl-4,5-dihydro-oxazole-5-carboxylic acid (4S,4aR)-6,6,8-trimethyl-4,4a,5,6,7,9-hexahydro-2-oxa-cyclopenta[f]azulen-4-yl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: NaOH / H2O 2: DCC; DMAP / CH2Cl2 / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: 41 percent / toluene / 8 h / Heating 2: 86 percent / NaOH / methanol; H2O / 20 °C 3: dicyclohexylcarbodiimide; 4-dimethylaminopyridine / CH2Cl2 / 20 °C View Scheme |
(2R,3S)-3-phenylisoserine hydrochloride
(4S,5R)-2,4-Diphenyl-4,5-dihydro-oxazole-5-carboxylic acid (1aS,3aS,6aS,6bR)-1a-formyl-5,5,6b-trimethyl-1,1a,3a,4,5,6,6a,6b-octahydro-cyclopropa[e]inden-2-ylmethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: NaOH / H2O 2: DCC; DMAP / CH2Cl2 / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: 41 percent / toluene / 8 h / Heating 2: 86 percent / NaOH / methanol; H2O / 20 °C 3: dicyclohexylcarbodiimide; 4-dimethylaminopyridine / CH2Cl2 / 20 °C View Scheme |
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