18315-79-2

Basic information

• Product Name: 2-Propen-1-one, 2-nitro-1,3-diphenyl-, (E)-
• CAS NO: 18315-79-2
• Molecular Formula: C15H11NO3
• Molecular Weight: 253.257
• Mol File: 18315-79-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-Propen-1-one, 2-nitro-1,3-diphenyl-, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one, 2-nitro-1,3-diphenyl-, (E)-(18315-79-2)
• EPA Substance Registry System: 2-Propen-1-one, 2-nitro-1,3-diphenyl-, (E)-(18315-79-2)

Safety Data

• Hazardous Substances Data: 18315-79-2(Hazardous Substances Data)

Upstream product

• 538-51-2 benzylidene phenylamine 
• 614-21-1 2-nitroacetophenone 
• 100-52-7 benzaldehyde 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 18315-85-0 (Z)-2-nitro-1,3-diphenylprop-2-en-1-one 
• 622-29-7 N-Benzylidenemethylamine 

Downstream Products

• 18315-85-0 (Z)-2-nitro-1,3-diphenylprop-2-en-1-one 

Relevant articles and documents

Highly stereoselective nitration of chalcone derivatives with nitric oxide

A novel nitration of chalcone derivatives with nitric oxide affords E-α-nitropropenones exclusively in good yield. The reaction is most likely initiated by electrophilic addition of nitric dioxide to the C=C double bond at the α-position. Georg Thieme Ver

Synthetic Diversity from a Versatile and Radical Nitrating Reagent

We leverage the slow liberation of nitrogen dioxide from a newly discovered, inexpensive succinimide-derived reagent to allow for the C?H diversification of alkenes and alkynes. Beyond furnishing a library of aryl β-nitroalkenes, this reagent provides unparalleled access to β-nitrohydrins and β-nitroethers. Detailed mechanistic studies strongly suggest that a mesolytic N?N bond fragmentation liberates a nitryl radical. Using in situ photo-sensitized, electron paramagnetic resonance spectroscopy, we observed direct evidence of a nitryl radical in solution by nitrone spin-trapping. To further exhibit versatility of N-nitrosuccinimide under photoredox conditions, the late-stage diversification of an extensive number of C?H partners to prepare isoxazolines and isoxazoles is presented. This approach allows for the formation of an in situ nitrile oxide from a ketone partner, the presence of which is detected by the formation of the corresponding furoxan when conducted in the absence of a dipolarophile. This 1,3-dipolar cycloaddition with nitrile oxides and alkenes or alkynes proceeds in a single-operational step using a mild, regioselective, and general protocol with broad chemoselectivity.

Research in antitumor chemotherapy. XII. Correlation between ethylenimine addition and cytotoxic action on tumor cells of compounds with activated ethylenic double bonds

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