183320-04-9 Usage
Description
6-O-DesMethoxyethyl-6-O-chloroethyl Erlotinib Hydrochloride is a chemical derivative of Erlotinib (E625000), which is an epidermal growth factor receptor inhibitor and tyrosine kinase inhibitor. 6-O-DesMethoxyethyl-6-O-chloroethyl Erlotinib Hydrochloride has been modified to potentially enhance the properties and effectiveness of the original Erlotinib in treating specific types of cancer.
Uses
Used in Pharmaceutical Industry:
6-O-DesMethoxyethyl-6-O-chloroethyl Erlotinib Hydrochloride is used as an anticancer agent for the treatment of patients with lung cancer. It functions by inhibiting the epidermal growth factor receptor (EGFR) and tyrosine kinase, which are often overactive in cancer cells, leading to uncontrolled cell growth and tumor formation. The modification in the chemical structure of Erlotinib may improve its efficacy, selectivity, and pharmacokinetic properties, making it a more effective treatment option for lung cancer patients.
Additionally, this derivative could potentially be used in research and development for other cancer types where EGFR and tyrosine kinase inhibition may be beneficial. Further studies would be required to explore its full potential and establish its safety and efficacy in various applications.
Check Digit Verification of cas no
The CAS Registry Mumber 183320-04-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,3,3,2 and 0 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 183320-04:
(8*1)+(7*8)+(6*3)+(5*3)+(4*2)+(3*0)+(2*0)+(1*4)=109
109 % 10 = 9
So 183320-04-9 is a valid CAS Registry Number.
183320-04-9Relevant articles and documents
Isolation of highly pure erlotinib hydrochloride by recrystallization after nucleophilic substitution of an impurity with piperazine
Zhang, Gengzhen,Zha, Linlin
, p. 2303 - 2309 (2013/07/26)
Optimized synthesis and purification of erlotinib hydrochloride (N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazoline-4-amine hydrochloride) were studied. Highly polar piperazine was used in a nucleophilic substitution reaction with the chlorinated intermediate byproduct N-(3-ethynylphenyl)-6(2- chloroethoxy)-7-(2-methoxyethoxy)quinazolin-4-amine hydrochloride. As a result, N-(3-ethynylphenyl)-6(2-chloroethoxy)-7-(2-methoxyethoxy)quinazolin-4-amine hydrochloride was completely transformed to N-(3-ethynylphenyl)-6(2- piperzinoethoxy)-7-(2-methoxyethoxy)quinazolin-4-amine hydrochloride. The polarity of N-(3-ethynylphenyl)-6(2-piperzinoethoxy)-7-(2-methoxyethoxy) quinazolin-4-amine hydrochloride was changed, and its molecule was enlarged. It was easy to remove this larger, more polar, compound by recrystallization. Highly pure erlotinib hydrochloride was obtained with low impurity content (99.9 %.
ALKYNYL AND AZIDO-SUBSTITUTED 4-ANILINOQUINAZOLINES
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, (2008/06/13)
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