183673-68-9

Basic information

• Product Name: 1-T-BOC-PIPERIDINE-4-SPIRO-5'-[1',3'-BIS-T-BOC]-HYDANTOIN
• Synonyms: 1-T-BOC-PIPERIDINE-4-SPIRO-5'-[1',3'-BIS-T-BOC]-HYDANTOIN;2,4-Dioxo-1,3,8-triazaspiro[4.5]decane-1,3,8-tricarboxylic Acid 1,3,8-Tris(1,1-diMethylethyl) Ester;Tri-Tert-Butyl 2,4-Dioxo-1,3,8-Triazaspiro[4.5]Decane-1,3,8-Tricarboxylate;tri-tert-butyl 2,4-dioxo-1,3,8-triazaspiro[4.5]decane-1,3,8-tricarboxylate(WXC03855)
• CAS NO: 183673-68-9
• Molecular Formula: C₂₂H₃₅N₃O₈
• Molecular Weight: 469.53
• Product Categories: Amino Acids & Derivatives;Hydantoins & Derivatives
• Mol File: 183673-68-9.mol
• Article Data: 6

Chemical Properties

• Melting Point: 242-244°C
• Appearance: /
• Solubility: Dichloromethane
• CAS DataBase Reference: 1-T-BOC-PIPERIDINE-4-SPIRO-5'-[1',3'-BIS-T-BOC]-HYDANTOIN(CAS DataBase Reference)
• NIST Chemistry Reference: 1-T-BOC-PIPERIDINE-4-SPIRO-5'-[1',3'-BIS-T-BOC]-HYDANTOIN(183673-68-9)
• EPA Substance Registry System: 1-T-BOC-PIPERIDINE-4-SPIRO-5'-[1',3'-BIS-T-BOC]-HYDANTOIN(183673-68-9)

Safety Data

• Hazardous Substances Data: 183673-68-9(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Powder

Uses

Different sources of media describe the Uses of 183673-68-9 differently. You can refer to the following data:
1. A cyclic a,a-disubstituted amino acid for preparation of water-soluble highly helical peptides
2. A cyclic α,α-disubstituted amino acid for preparation of water-soluble highly helical peptides.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 183673-70-3 tert-butyl 2,4-dioxo-1,3,8-triazaspiro[4.5]decane-8-carboxylate 
• 13625-39-3 1,3,8-triaza-spiro[4.5]decan-2,4-dione 
• 41979-39-9 4-piperidone hydrochloride 
• 73390-11-1 4-piperidinone monohydrate 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 40064-34-4 piperidine-4,4-diol hydrochloride 

Downstream Products

• 183673-71-4 4-amino-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid 
• 940290-02-8 4-[(benzyloxycarbonyl)amino]-1-(tert-butyloxycarbonyl)piperidine-4-carboxylic acid tryptamide 
• 940290-04-0 4-(3-(4-benzyloxyphenyl)-propenoyl-amino)-1-(tert-butyloxycarbonyl)piperidine-4-carboxylic acid tryptamide 
• 288154-16-5 4-(Benzyloxycarbonylamino)-1-(tert-butoxycarbonyl)-piperidine-4-carboxylic Acid 
• 495414-58-9 4-allyloxycarbonylamino-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester 
• 183673-66-7 N-Fmoc-amino-(4-N-Boc-piperidinyl)carboxylic acid 
• 392331-67-8 1-(tert-butyl) 4-methyl 4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)piperidine-1,4-dicarboxylate 
• 917834-41-4 tert-butyl 4-(benzyloxycarbonylamino)-4-(hydroxymethyl)piperidine-1-carboxylate 
• 1091681-76-3 4-benzyloxycarbonylamino-4-chloromethyl-piperidine-1-carboxylic acid tert-butyl ester 
• 1091681-78-5 4-benzyloxycarbonylamino-4-(4-fluoro-benzyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 1091681-82-1 [1-((S)-2-tert-butoxycarbonylamino-3,3-dimethyl-butyryl)-4-(4-fluoro-benzyl)-piperidin-4-yl]-carbamic acid benzyl ester 
• 1091681-80-9 [4-(4-fluoro-benzyl)-piperidin-4-yl]-carbamic acid benzyl ester hydrochloride 
• 1091682-14-2 (R)-N-{(S)-1-[4-amino-4-(4-fluoro-benzyl)-piperidine-1-carbonyl]-2,2-dimethyl-propyl}-2-cyclopentylmethyl-3-(formyl-hydroxy-amino)-propionamide 
• 1091681-74-1 [1-((S)-2-amino-3,3-dimethyl-butyryl)-4-(4-fluoro-benzyl)-piperidin-4-yl]-carbamic acid benzyl ester hydrochloride 

Relevant articles and documents

A NEW PEPTIDE DEFORMYLASE INHIBITOR COMPOUND AND MANUFACTURING PROCESS THEREOF

The present invention relates to the novel antibacterial compounds having potent antibacterial activity as inhibitors of peptide deformylase. This invention further relates to pharmaceutically acceptable salts thereof, to processes for their preparation, and to pharmaceutical compositions containing them as an active ingredient.

N-(3-(4-Hydroxyphenyl)-propenoyl)-amino acid tryptamides as SIRT2 inhibitors

A series of N-(3-(4-hydroxyphenyl)-propenoyl)-amino acid tryptamides was based on a previously reported new SIRT2 inhibitor from our group, and it was designed to study if the molecular size of the compound could be reduced. The most potent compounds, N-(3-(4-hydroxyphenyl)-propenoyl)-2-aminoisobutyric acid tryptamide and N-(3-(4-hydroxyphenyl)-propenoyl)-l-alanine tryptamide, were equipotent, 30% smaller in molecular weight, and slightly more selective (SIRT2/SIRT1) than the parent compound.

Parallel solution- and solid-phase synthesis of spirohydantoin derivatives as neurokinin-1 receptor ligands

The combination of the 3,5-bis(trifluoromethyl)phenyl group with a spirohydantoin motive as a central scaffold was the basis for the design of a combinatorial library targeted towards the neurokinin-1 receptor. A solution- and solid-phase procedure is described and binding affinities of representative compounds presented.