18368-64-4 Usage
Description
2-Chloro-5-methylpyridine is an organic compound that serves as a crucial intermediate in the synthesis of various chemical products. It is characterized by its clear light yellow to straw-yellow liquid appearance and holds significance in the chemical and pharmaceutical industries due to its versatile reactivity and potential applications.
Uses
Used in Chemical Synthesis:
2-Chloro-5-methylpyridine is used as a key intermediate for the synthesis of several chemical compounds, including:
2-methylthio-5-pyridinemethylene amine, which may have applications in the development of pharmaceuticals or other specialty chemicals.
5-methyl-2,2′-bipyridine, a compound that could be utilized in the creation of complex organic molecules or materials with specific properties.
1-(5′-methyl-2,2′-bipyridin-5-yl)-2,5-dimethyl-1H-pyrrole, which might be employed in the production of novel chemical entities with potential applications in various fields.
Used in Pesticide Industry:
2-Chloro-5-methylpyridine is also used as a pesticide intermediate, playing a vital role in the development of new pesticides to protect crops and enhance agricultural productivity. Its chemical properties make it a valuable component in the formulation of effective and targeted pest control solutions.
Check Digit Verification of cas no
The CAS Registry Mumber 18368-64-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,3,6 and 8 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 18368-64:
(7*1)+(6*8)+(5*3)+(4*6)+(3*8)+(2*6)+(1*4)=134
134 % 10 = 4
So 18368-64-4 is a valid CAS Registry Number.
InChI:InChI=1/C6H6ClN/c1-5-2-3-6(7)8-4-5/h2-4H,1H3
18368-64-4Relevant articles and documents
Convenient access to new chiral ferroceno-(iso)quinolines
Mamane, Victor,Fort, Yves
, p. 8220 - 8223 (2005)
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Efficient Phosphorus-Free Chlorination of Hydroxy Aza-Arenes and Their Application in One-Pot Pharmaceutical Synthesis
Wang, Jian,Li, Yan-Hui,Pan, Song-Cheng,Li, Ming-Fang,Du, Wenting,Yin, Hong,Li, Jing-Hua
supporting information, p. 146 - 153 (2020/03/10)
The chlorination of hydroxy aza-arenes with bis(trichloromethyl) carbonate (BTC) and SOCl2 has been effectively performed by refluxing with 5 wt % 4-dimethylaminopyridine (DMAP) as a catalyst. Various substrates are chlorinated with high yields. The obtained chlorinated aza-arenes can be used directly with simple workup for succedent one-pot synthesis on a large scale.
Transition-metal-free decarboxylative halogenation of 2-picolinic acids with dihalomethane under oxygen conditions
Zhang, Xitao,Feng, Xiujuan,Zhang, Haixia,Yamamoto, Yoshinori,Bao, Ming
supporting information, p. 5565 - 5570 (2019/10/22)
A convenient and efficient method for the synthesis of 2-halogen-substituted pyridines is described. The decarboxylative halogenation of 2-picolinic acids with dihalomethane proceeded smoothly via N-chlorocarbene intermediates to afford 2-halogen-substituted pyridines in satisfactory to excellent yields under transition-metal-free conditions. This new type of decarboxylative halogenation is operationally simple and exhibits high functional-group tolerance.
