88260-11-1Relevant articles and documents
Discovery of aminoglycoside mimetics by NMR-based screening of Escherichia coli A-site RNA
Yu, Liping,Oost, Thorsten K.,Schkeryantz, Jeffrey M.,Yang, Jianguo,Janowick, Dave,Fesik, Stephen W.
, p. 4444 - 4450 (2003)
A method is described for the NMR-based screening for the discovery of aminoglycoside mimetics that bind to Escherichia coli A-site RNA. Although aminoglycosides are clinically useful, they exhibit high nephrotoxicity and ototoxicity, and their overuse ha