18423-43-3

Basic information

• Product Name: Deoxythymidine triphosphate
• Synonyms: DTTP;[HYDROXY-[HYDROXY-[[3-HYDROXY-5-[(5-METHYL-2,4-DIOXO-1H-PYRIMIDIN-1-YL)]TETRAHYDROFURAN-2-YL]METHOXY]PHOSPHINOYL]OXY-PHOSPHINOYL]OXYPHOSPHONIC ACID;dTTP 2-Deoxythymidine-5-triphosphate, trisodium salt, dihydrate;thymidine 5'-triphosphate sodium;THYMIDINE 5'-TRIPHOSPHATE SODIUM 100 MM AQUEOUS SOL;THYMIDINE 5'-TRIPHOSPHATE SODIUM*PCR REA GENT;thymidine 5'-triphosphate sodium salt solution;Thymidine-5''-triphosphoric acid sodium salt
• CAS NO: 18423-43-3
• Molecular Formula: C10H17N2O13P3
• Molecular Weight: 466.17
• EINECS: 1806241-263-5
• Product Categories: Bases & Related Reagents;Carbohydrates & Derivatives;Heterocycles;Nucleotides;Phosphorylating and Phosphitylating Agents;NULL
• Mol File: 18423-43-3.mol
• Article Data: 0

Chemical Properties

• Melting Point: >0°C
• Appearance: colorless/
• Density: 1.922 g/cm³
• Storage Temp.: −20°C
• CAS DataBase Reference: Deoxythymidine triphosphate(CAS DataBase Reference)
• NIST Chemistry Reference: Deoxythymidine triphosphate(18423-43-3)
• EPA Substance Registry System: Deoxythymidine triphosphate(18423-43-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 18423-43-3(Hazardous Substances Data)

Usage

Description

Deoxythymidine triphosphate (dTTP) is a 100 mM clear, colorless solution of lithium salt with a pH of 7. It is a white amorphous powder and is a metabolite of Thymidine (T412000), also serving as a Thymidine (T412000) analogue as a phosphate donor.

Uses

1. Used in Molecular Biology Research:
Deoxythymidine triphosphate is used as a reagent for DNA sequencing, labeling, and various amplification and primer-extension reactions. It plays a crucial role in PCR fingerprinting and PCR techniques.
2. Used in High-Quality Reagent Applications:
Deoxythymidine triphosphate, in its PCR Grade form, is suitable for applications where high-quality reagents are essential. These procedures include reverse transcription (RT), polymerase chain reaction (PCR), RT-PCR, DNA labeling reactions, and sequencing/cycle sequencing analysis.
3. Used in Diagnostics and Research Laboratories:
As a key component in molecular biology and genetic research, dTTP is widely used in diagnostics and research laboratories for various experiments and analyses related to DNA synthesis and manipulation.

Related news

Full paperIncorporation of Deoxythymidine triphosphate (cas 18423-43-3) into nuclear DNA of developing frog embryos in vitro☆09/06/2019

The rate of incorporation of labeled precursor into DNA of isolated nuclei decreased from gastrulation to the tailbud stage in developing frog embryos. The addition of saturating amounts of calf thymus DNA revealed that the activities of the enzyme(s) which incorporates deoxythymidine triphospha...detailed

Short communicationIncreased Deoxythymidine triphosphate (cas 18423-43-3) levels is a feature of relative cognitive decline08/31/2019

Mitochondrial bioenergetics, mitochondrial reactive oxygen species (ROS) and cellular levels of nucleotides have been hypothesized as early indicators of Alzheimer's disease (AD). Utilizing relative decline of cognitive ability as a predictor of AD risk, we evaluated the correlation between...detailed