1846-90-8

Basic information

• Product Name: N-benzyl-2-oxo-2H-chromene-3-carboxamide
• Synonyms: 2H-1-Benzopyran-3-carboxamide, 2-oxo-N-(phenylmethyl)-; N-Benzyl-2-oxo-2H-chromene-3-carboxamide
• CAS NO: 1846-90-8
• Molecular Formula: C₁₇H₁₃NO₃
• Molecular Weight: 279.29
• Mol File: 1846-90-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 569.8°C at 760 mmHg
• Flash Point: 298.4°C
• Density: 1.293g/cm³
• Vapor Pressure: 5.39E-13mmHg at 25°C
• Refractive Index: 1.632
• CAS DataBase Reference: N-benzyl-2-oxo-2H-chromene-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-2-oxo-2H-chromene-3-carboxamide(1846-90-8)
• EPA Substance Registry System: N-benzyl-2-oxo-2H-chromene-3-carboxamide(1846-90-8)

Safety Data

• Hazardous Substances Data: 1846-90-8(Hazardous Substances Data)

Upstream product

• 3757-06-0 coumarin 3-carboxylic acid chloride 
• 504-64-3 carbon suboxide 
• 886-08-8 N-(benzyl)salicylaldimine 
• 15781-70-1 malonic acid bis-(2,4,6-trichloro-phenyl) ester 
• 90-02-8 salicylaldehyde 
• 100-46-9 benzylamine 
• 531-81-7 2-oxo-2H-chromene-3-carboxylic acid 
• 95-20-5 2-methyl-1H-indole 
• 21259-42-7 methyl 2-oxo-2H-chromene-3-carboxylate 
• 1846-76-0 ethyl coumarin-3-carboxylate 

Downstream Products

• 97095-03-9 N-Benzyl-6a,7,10,10a-tetrahydro-8,9-dimethyl-6-oxo-6H-5-oxaphenanthren-6a-carboxamid 

Relevant articles and documents

KPF6-Mediated Esterification and Amidation of Carboxylic Acids

A novel KPF6-promoted green method has been developed for the synthesis of esters and amides. A wide range of carboxylic acids and alcohols or amines worked well under the developed reaction conditions, thus providing good to excellent (61-98%) yields of

Design, synthesis and antifungal activity evaluation of coumarin-3-carboxamide derivatives

A series of coumarin-3-carboxamides/hydrazides have been designed and synthesized, all the target compounds were evaluated in vitro for their antifungal activity against Botrytis cinerea, Alternaria solani, Gibberella zeae, Rhizoctorzia solani, Cucumber anthrax and Alternaria leaf spot, some of the designed compounds 4a-4g exhibited potential activity in the primary assays, this highlighted by the compounds 4a, 4d, 4e and 4f, EC50 values of which against Rhizoctorzia solani were as low as 1.80 μg/mL, 2.50 μg/mL, 2.25 μg/mL and 2.10 μg/mL, respectively, exhibiting more effective control with that of the positive control than Boscalid. Furthermore, compounds 4a and 4e represented equivalent antifungal activity with Boscalid against Botrytis cinerea.

Synthesis and research of benzylamides of some isocyclic and heterocyclic acids as potential anticonvulsants

A series of benzylamides of isocyclic and heterocyclic acids was synthesized and tested in Anticonvulsant Screening Project (ASP) of Antiepileptic Drug Development Program (ADDP) of NIH. Near all synthesized derivatives of heterocyclic acids showed activity. All obtained derivatives of mono- and bicyclic isocyclic acids were inactive. The power of action of heterocyclic acids derivatives seems does not depend upon kind of heteroatom (N, O or S). One of the compounds (2-furoic acid benzylamide (4)) appeared most promising. It showed in minimal clonic seizure (6Hz) test (ASP) in rats after i. p. administration: MES ED50 = 36.5 mg/kg, TOX TD50 = 269.75 mg/kg, and PI = 7.39.