185039-29-6

Basic information

• Product Name: 6-(2,6-Dichlorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-imine
• Synonyms: 6-(2,6-Dichlorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-imine;6-(2,6-Dichlorophenyl)-8-Methyl-2-Methylsulfanyl-8H-pyrido[2,3-d]-pyriMidin-7-ylideneaMine
• CAS NO: 185039-29-6
• Molecular Formula: C₁₅H₁₂Cl₂N₄S
• Molecular Weight: 351.25358
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 185039-29-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 501.8°C at 760 mmHg
• Flash Point: 257.3°C
• Appearance: /
• Density: 1.48g/cm³
• Vapor Pressure: 3.36E-10mmHg at 25°C
• Refractive Index: 1.71
• Solubility: Chloroform, Dichloromethane, DMSO, Methanol
• CAS DataBase Reference: 6-(2,6-Dichlorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-imine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(2,6-Dichlorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-imine(185039-29-6)
• EPA Substance Registry System: 6-(2,6-Dichlorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-imine(185039-29-6)

Safety Data

• Hazardous Substances Data: 185039-29-6(Hazardous Substances Data)

Usage

Description

6-(2,6-Dichlorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-imine is a red solid compound that serves as an intermediate in the synthesis of various pharmaceuticals, particularly those with antitumor and tyrosine kinase inhibitory properties. Its chemical structure contributes to its potential applications in the medical field, making it a valuable compound for further research and development.

Uses

Used in Pharmaceutical Industry:
6-(2,6-Dichlorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-imine is used as an intermediate in the preparation of antitumor agents for the treatment of various types of cancer. Its chemical properties allow it to be a key component in the development of drugs that target and inhibit the growth of cancer cells.
Additionally, 6-(2,6-Dichlorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-imine is used as an intermediate in the synthesis of tyrosine kinase inhibitors. These inhibitors play a crucial role in regulating cellular processes and are essential for the development of targeted therapies for cancer and other diseases.

InChI:InChI=1/C15H12Cl2N4S/c1-21-13(18)9(12-10(16)4-3-5-11(12)17)6-8-7-19-15(22-2)20-14(8)21/h3-7,18H,1-2H3

Upstream product

• 3215-64-3 2,6-dichlorophenylacetonitrile 
• 185040-32-8 4-methylamino-2-methylthiopyrimidine-5-carboxaldehyde 
• 17759-30-7 (4-methylamino-2-methylsulfanyl-pyrimidin-5-yl)-methanol 
• 5909-24-0 4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester 
• 76360-82-2 4-methylamino-2-methylsulfanyl-pyrimidine-5-carboxylic acid ethyl ester 

Downstream Products

• 185039-37-6 N-[6-(2,6-dichlorophenyl)-8-methyl-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-ylidene]-acetamide 
• 212391-51-0 6-(2,6-Dichloro-phenyl)-2-methanesulfinyl-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-ylideneamine 
• 185039-89-8 PD-166285 
• 185039-34-3 6-(2,6-dichlorophenyl)-2-hydroxy-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one 
• 185039-46-7 6-(2,6-dichlorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one 
• 185039-62-7 6-(2,6-Dichlorophenyl)-2-methanesulfinyl-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one 
• 185039-48-9 6-(2,6-dichlorophenyl)-8-methyl-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one 
• 212391-57-6 SKI DV₂ 47 

Relevant articles and documents

Part 3: Notch-sparing γ-secretase inhibitors: SAR studies of 2-substituted aminopyridopyrimidinones

In search for novel lead compounds as γ-secretase inhibitors, analogs of aminopyrido[2,3-d]pyrimidin-7-ones (I) were synthesized and evaluated for inhibitory effects on amyloid-β-peptide production and cleavage of the Notch1 receptor mediated by γ-secretase. Selected pyridopyrimidines, such as 1, 8, 9,10, 11 and 16 are γ-secretase inhibitors that did not have an effect on Notch1 receptor processing.

N-OXIDES OF AMINO CONTAINING PYRIDO [2,3-D] PYRIMIDINES

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Preparation of pyrido[2,3-d]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation.

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