185104-11-4 Usage
Description
N-[2-[Bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxamide hydrochloride is a complex organic compound with a chemical structure that suggests potential pharmaceutical applications. It is characterized by its unique arrangement of atoms and functional groups, which may contribute to its specific properties and interactions with biological systems.
Uses
Used in Pharmaceutical Industry:
N-[2-[Bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxamide hydrochloride is used as a potential therapeutic agent for various medical conditions. Its specific application reason is yet to be fully elucidated, but its chemical structure suggests that it may have interactions with biological targets, such as enzymes or receptors, that could be relevant to the treatment of certain diseases.
Used in Research and Development:
In the field of research and development, N-[2-[Bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxamide hydrochloride can be used as a starting material or a tool compound for the synthesis of new drugs or the study of biological processes. Its unique structure may provide insights into the design of more effective and targeted pharmaceuticals.
Please note that the provided materials do not contain specific information about the uses of N-[2-[Bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxamide hydrochloride. The uses mentioned above are hypothetical and based on the general knowledge of similar compounds. Further research and experimentation would be required to confirm its actual applications and benefits.
Biological Activity
Acotiamide hydrochloride is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with an IC50 of 1.79 μM. Acotiamide hydrochloride can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide hydrochloride has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory.
Check Digit Verification of cas no
The CAS Registry Mumber 185104-11-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,5,1,0 and 4 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 185104-11:
(8*1)+(7*8)+(6*5)+(5*1)+(4*0)+(3*4)+(2*1)+(1*1)=114
114 % 10 = 4
So 185104-11-4 is a valid CAS Registry Number.
185104-11-4Relevant articles and documents
Preparation method of acotiamide hydrochloride impurity
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Paragraph 0022; 0024, (2020/08/02)
The invention discloses a preparation method of an acotiamide hydrochloride impurity. The method comprises the following steps: carrying out acylating chlorination on a raw material 2,4,5-trimethoxybenzoic acid to obtain 2,4,5-trimethoxybenzoyl chloride, and carrying out an amidation reaction on the 2,4,5-trimethoxybenzoyl chloride and 2-amino-4-ethoxycarbonyl-1,3-thiazole to obtain 2-amino-4-ethoxycarbonyl-1,3-thiazole (intermediate 1); hydrolyzing the intermediate 1 with sodium hydroxide to obtain 2-[N-(2,4,5-trimethoxybenzoyl)amino]-4-carboxyl-1,3-thiazole (intermediate 2); and performing an acylating chlorination reaction on the intermediate 2 to obtain an acyl chloride group, performing an amidation reaction on the acyl chloride group and N,N-diisopropylethylenediamine to obtain N-[2-(diisopropylamino)ethyl]-2-[(2,4,5-trimethoxybenzoyl)amino]-4-thiazole formamide (acotiamide), and performing a salt forming reaction on the acotiamide to obtain acotiamide hydrochloride. The preparation method of the acotiamide hydrochloride impurity has the advantages of mild reaction conditions, simple operation, low cost and high yield, and is suitable for industrial production.
IMPROVED METHOD FOR MANUFACTURING ACOTIAMIDE
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Paragraph 0029, (2019/06/20)
PROBLEM TO BE SOLVED: To provide a method for manufacturing acotiamide or acotiamide hydrochloride trihydrate capable of avoiding the use of 2,4,5-trimethoxy benzoyl chloride that is an intermediate manufactured by using thionyl chloride. SOLUTION: There is provided a method for manufacturing acotiamide or acotiamide hydrochloride trihydrate comprising the steps of: manufacturing 2-[(2,4,5-trimethoxy benzoyl) amino]-1,3-thiazole-4-ethyl carboxylate from 2,4,5-trimethoxy benzoic acid S- (benzothiazole-2-yl) and 2-amino-1,3-thiazole-4-ethyl carboxylate; manufacturing 2-[(2-hydroxy-4,5-dimethoxy benzoyl) amino]-1,3-thiazole-4-ethyl carboxylate by demethylation; and reacting the resultant product with N,N-diisopropyl ethylenediamine to manufacture acotiamide. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT
A synthesis method of arab League tests for the amine hydrochloride
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, (2017/08/25)
The invention relates to a synthetic method of acotiamide hydrochloride. The synthetic route of the acotiamide hydrochloride comprises the following steps: protecting hydroxyl vicinal to carboxyl in a formula (1) compound to obtain a formula (2) compound,
