185421-97-0Relevant articles and documents
Method for (7S)-5- synthesizing [2.4] tert -7-butyl carbamic acid tert-butyl (by machine translation)
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Paragraph 0204-0206; 0208-0209, (2019/12/02)
To the preparation method disclosed by the invention (7S) - 5 - [2.4] the raw materials are easily available, the process is simple, the (>99.0% ee) optical purity of the obtained product is high, and the method is suitable for industrial large-scale production. The invention provides a novel method for synthesizing a spirocyclic intermediate of sitafloxacin. (by machine translation)
Enantioselective synthesis of 3-aminopyrrolidines
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, (2008/06/13)
The invention relates to a process of preparing a chiral compound of the formula: wherein R1is selected from the group consisting of hydrogen and lower alkyl, and R2and R2′are the same, and R2and R2′are selected from a group consisting of hydrogen and primary alkyl, or R2and R2′taken together form a C3to C6cycloalkyl, comprising the steps of chirally reducing a β-keto ester to afford a β-hydroxy ester, activating the β-hydroxy ester by treatment with a sulfonic acid or a derivative thereof to provide an activated compound having sulfonate leaving group, displacing the sulfonate leaving group with an azido moiety, or treating the activated compound with an alkylamine, deprotecting and cyclizing to afford a pyrrolidinone, and reducing the pyrrolidinone to afford a stereoisomerically preferred 3-aminopyrrolidine derivative.
