185525-88-6Relevant articles and documents
Synthesis and biological activities of spiroheterocyclic growth hormone secretagogues
Chen, Meng-Hsin,Pollard, Patrick P.,Patchett, Arthur A.,Cheng, Kang,Liente, Wei,Chan, Wanda W.-S.,Butler, Bridget,Jacks, Thomas M.,Smith, Roy G.
, p. 1261 - 1266 (2007/10/03)
The synthesis and biological activities of a series of spiroheterocyclic growth hormone secretagogues are reported. Modification of the spiroindane part-structure of the prototypal secretagogue L-162,752 revealed that the spiroindane could be replaced with spirobenzodihydrothiophen derivatives to enhance not only in vitro potency but also oral activity. In this study non- aromatic D-2-amino-4-cyclohexylbutanoic analogs (8a-8d) were also identified to be active secretagogues.
Spiro piperidines and homologs promote release of growth hormone
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, (2008/06/13)
There are disclosed certain novel compounds identified as spiro piperidines and homologs which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such spiro compounds as the active ingredient thereof are also disclosed.