185526-02-7

Basic information

• Product Name: Carbamic acid, [3-[[2-(2,3-dihydrospiro[1H-indene-1,4'-piperidin]-1'-yl)-2-oxo-1-[(phenyl methoxy)methyl]ethyl]amino]-1,1-dimethyl-3-oxopropyl]-, 1,1-dimethylethyl ester, (R)-
• CAS NO: 185526-02-7
• Molecular Formula: C33H45N3O5
• Molecular Weight: 563.737
• Mol File: 185526-02-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [3-[[2-(2,3-dihydrospiro[1H-indene-1,4'-piperidin]-1'-yl)-2-oxo-1-[(phenyl methoxy)methyl]ethyl]amino]-1,1-dimethyl-3-oxopropyl]-, 1,1-dimethylethyl ester, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [3-[[2-(2,3-dihydrospiro[1H-indene-1,4'-piperidin]-1'-yl)-2-oxo-1-[(phenyl methoxy)methyl]ethyl]amino]-1,1-dimethyl-3-oxopropyl]-, 1,1-dimethylethyl ester, (R)-(185526-02-7)
• EPA Substance Registry System: Carbamic acid, [3-[[2-(2,3-dihydrospiro[1H-indene-1,4'-piperidin]-1'-yl)-2-oxo-1-[(phenyl methoxy)methyl]ethyl]amino]-1,1-dimethyl-3-oxopropyl]-, 1,1-dimethylethyl ester, (R)-(185526-02-7)

Safety Data

• Hazardous Substances Data: 185526-02-7(Hazardous Substances Data)

Upstream product

• 129765-95-3 3-[(tert-butoxycarbonyl)amino]-3-methylbutanoic acid 
• 185525-89-7 1'-[[2(R)-amino-1-oxo-3-(phenylmethyloxy)]propyl]-2,3-dihydrospiro[1H-indene-1,4'-piperidine] 
• 185525-88-6 N-[1(R)-[(2,3-dihydrospiro[1H-indene-1,4'-piperidin]-1'-yl)carbonyl]-2-(phenylmethyloxy)ethyl]carbamic acid 1,1-dimethylethyl ester 
• 96651-85-3 2,3-dihydrospiro[1H-indene-1,4'-piperidine] hydrochloride 
• 47173-80-8 N-Boc-D-serine(Bzl)-OH 

Relevant articles and documents

Peptidomimetic growth hormone secretagogues: Synthesis and biological activities of analogs varied at the indole nucleus of the prototypical spiropiperidine L-162,752

SAR studies around the indole nucleus of the prototypical peptidomimetic L-162,752 revealed that the D-Trp could be replaced with 3-phenylpropyl-D-glycine and O-benzyl-D-serine to provide secretagogues with comparable intrinsic activity but with significantly better oral activity in dogs. Use of dimethyl β-alanine amino side-chains led to a considerable loss of activity in the D-homophenylalanine and O-benzyl-D-serine series.