185913-28-4Relevant articles and documents
Method for synthesizing 2-fluoro-6-hydroxyphenylboronic acid
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Paragraph 0008; 0018-0019; 0021, (2020/06/17)
The invention belongs to the field of synthesis of pharmaceutical compounds, and provides a method for synthesizing 2-fluoro-6-hydroxyphenylboronic acid. The method comprises the following two steps:1) synthesizing an intermediate: reacting 3-fluorophenol
Foiling Normal Patterns of Crystallization by Design. Polymorphism of Phosphangulene Chalcogenides
Heskia, Alice,Maris, Thierry,Wuest, James D.
, p. 5390 - 5406 (2019/09/12)
Phosphangulene (1) has a well-defined hexacyclic structure with a distinctive conical shape and an electron-rich aromatic surface. Molecules of phosphangulene are disposed to crystallize in parallel π-stacks. This preference can be thwarted by adding a si
C- ARYL GLYCOSID DERIVATIVES, PHARMACEUTICAL COMPOSITION, PREPARATION PROCESS AND USES THEREOF
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Paragraph 0096; 0378; 0379; 0380, (2017/04/19)
This invention relates to a kind of C-aryl glycoside derivatives, its pharmaceutical compositions, preparation methods, and uses thereof. The preparation method comprises: method 1: in a solvent, deprotecting the acetyl protecting groups of compound 1-f in the presence of a base; method 2: 1) compound 2-g reacts with via Mitsunobu reaction; 2) deprotecting the acetyl protecting groups of compound 2-f obtained from step 1; method 3: 1) compound 2-g reacts with via nucleophilic substitution reaction; 2) deprotecting the acetyl protecting groups of compound 3-f obtained from step 1. The pharmaceutical composition comprises a kind of C-aryl glycoside derivatives; it's pharmaceutically acceptable salts and/or prodrugs thereof and excipient thereof. This invention further relates to a kind of C-aryl glycoside derivatives, it's pharmaceutically acceptable salts or pharmaceutical compositions thereof for the use in preparation of a SGLT inhibitor. The C-aryl glycoside derivatives of this invention provides a new direction for the study of SGLT inhibitors.